Search Results - "Jonkman, J.H.G."

‘High throughput’ solid-phase extraction technology and turbo ionspray LC-MS-MS applied to the determination of haloperidol in human plasma by Hempenius, J., Steenvoorden, R.J.J.M., Lagerwerf, F.M., Wieling, J., Jonkman, J.H.G.

“…A quantitative method for the analysis of haloperidol in human plasma is described. Sample clean-up was performed by means of solid-phase extraction using 3M…”
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Food Interactions with Sustained-Release Theophylline Preparations1: A Review by Jonkman, J.H.G.

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Rational experimental design for bioanalytical methods validation illustration using an assay method for total captopril in plasma by Wieling, J., Hendriks, G., Tamminga, W.J., Hempenius, J., Mensink, C.K., Oosterhuis, B., Jonkman, J.H.G.

“…Generally, bioanalytical chromatographic methods are validated according to a predefined programme and distinguish a pre-validation phase, a main validation…”
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Bioequivalence of 2 sustained release preparation of isosorbide-5-mononitrate by Bron, J., Jonkman, J.H.G., Steinijans, V.W., Dileti, E.

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Pharmacokinetics and pharmacodynamics of a single dose of recombinant human growth hormone after subcutaneous administration by jet-injection : comparison with conventional needle-injection by VERHAGEN, A, EBELS, J. T, DOGTEROM, A. A, JONKMAN, J. H. G

“…The pharmacokinetics and pharmacodynamics of recombinant human growth hormone (rhGH) were studied after a single subcutaneous dose given by jet-injection, and…”
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Disposition of One Dose of 14C‐Repaglinide During Non‐Labeled Repaglinide Multiple Dosing by Hatorp, V., Van Heiningen, P.N.M., Van Lier, J.J., Van de Merbel, N.C., Nielsen, K.K., Hansen, K.T., Jonkman, J.H.G.

“…Clinical Pharmacology & Therapeutics (1999) 65, 187–187; doi:…”
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An automated analytical method for the determination of felbamate in human plasma by robotic sample preparation and reversed-phase high performance liquid chromatography by Hempenius, J, Hendriks, G, Hingstman, J, Mensink, C K, Jonkman, J H, Lin, C C

“…An automated analytical method for the determination of felbamate in human plasma is described. Sample cleanup and preparation was performed by means of a…”
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Omeprazole: pharmacology, pharmacokinetics and interactions by Oosterhuis, B, Jonkman, J H

“…Omeprazole is a prodrug which is converted to its active form only at the site of action, namely the parietal cell. There it binds irreversibly with…”
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Zatebradine: pharmacokinetics of a novel heart-rate-lowering agent after intravenous infusion and oral administration to healthy subjects by Roth, W, Bauer, E, Heinzel, G, Cornelissen, P J, van Tol, R G, Jonkman, J H, Zuiderwijk, P B

“…Zatebradine (1; UL-FS 49 CL; 1,3,4,5-[tetrahydro-7,8-dimethoxy-3-[3-[ [2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-2H-3-benzazepin- 2-on- hydrochloride)…”
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A comparative study of the steady-state pharmacokinetics of immediate-release and controlled-release diltiazem tablets by LEEUWENKAMP, O. R, VISSCHER, H. W, MENSINK, C. K, JONKMAN, J. H. G

“…We have studied the controlled-release properties and relative systemic availabilities of two dosages of the same controlled-release (CR) diltiazem tablet…”
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Percutaneous absorption of amorolfine following a single topical application of an amorolfine cream formulation by Roncari, G, Ponelle, C, Zumbrunnen, R, Guenzi, A, Dingemanse, J, Jonkman, J H

“…In an open-label, parallel-group, randomized study percutaneous absorption of 14C-labelled amorolfine incorporated into a cream formulation was assessed in…”
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Development of a laboratory robotic system for automated bioanalytical methods--I. The determination of theophylline in human plasma: a comparison between the robotized and manual method by Hempenius, J, Wieling, J, Jonkman, J H, de Noord, O E, Coenegracht, P M, Doornbos, D A

“…The quality of bioanalytical methods is often determined by the quality of sample preparation. Using a robot for sample treatment may give better results than…”
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Development of a laboratory robotic system for automated bioanalytical methods--II. A robot computer program for guarding totally automated bioanalytical methods by Wieling, J, Hempenius, J, Jeuring, H J, Jonkman, J H, Coenegracht, P M, Doornbos, D A

“…The application of fully automated, unattended sample preparation performed by a laboratory robot for the analysis of drugs in biological samples requires the…”
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High-throughput solid-phase extraction for the determination of cimetidine in human plasma by Hempenius, J, Wieling, J, Brakenhoff, J.P.G, Maris, F.A, Jonkman, J.H.G

“…For the implementation and validation of an automated `high-throughput' solid-phase extraction (SPE) system, using microtiter solid-phase technology and a…”
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Lack of influence of co-trimoxazole on theophylline pharmacokinetics by Jonkman, J H, Van der Boon, W J, Schoenmaker, R, Holtkamp, A H, Hempenius, J

“…In an open cross-over experiment, the influence of the antimicrobial agent co-trimoxazole on the single-dose pharmacokinetics of theophylline was studied in…”
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Protective effect of choline theophyllinate on histamine, acetylcholine, and propranolol-induced airflow obstruction by Koëter, G H, Meurs, H, Jonkman, J H, de Vries, K

“…The protective effect of choline theophyllinate, 600 mg orally, was studied by examining the effects on inhaled histamine, acetylcholine, and propranolol in 19…”
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Determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid in human plasma and urine by high-performance liquid chromatography with tandem mass spectrometric detection by van de Merbel, N.C, Tinke, A.P, Oosterhuis, B, Jonkman, J.H.G, Bohle, J.F

“…A method is described for the determination of pilocarpine and its degradation products isopilocarpine, pilocarpic acid and isopilocarpic acid in human plasma…”
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Clinical pharmacokinetics of amoxycillin and theophylline during cotreatment with both medicaments by Jonkman, J H, van der Boon, W J, Schoenmaker, R, Holtkamp, A H, Hempenius, J

“…The influence of amoxycillin and theophylline on their mutual steady-state pharmacokinetics was studied in healthy adults by comparing the pharmacokinetic…”
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Validated method for the determination of idazoxan in human plasma by liquid chromatography with tandem mass spectrometric detection by van de Merbel, N.C, Tinke, A.P, van Dongen, W.D, Oosterhuis, B, Jonkman, J.H.G, Ladure, Ph, Puozzo, C

“…A liquid chromatography–tandem mass spectrometry method for the determination of idazoxan in human (heparin) plasma is presented, which was developed and…”
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First-pass effect after rectal administration of thiazinamium methylsulfate by Jonkman, J H, van Bork, L E, Wijsbeek, J, Bolhuis-de Vries, A S, de Zeeuw, R A, Orie, N G, Cox, H L

“…The absorption and metabolism of the quaternary ammonium compound thiazinamium methylsulfate were studied in humans using plasma concentration data and urinary…”
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