Search Results - "Jonjic, Stipan"

Modulation of innate and adaptive immunity by cytomegaloviruses by Berry, Richard, Watson, Gabrielle M., Jonjic, Stipan, Degli-Esposti, Mariapia A., Rossjohn, Jamie

“…The coordinated activities of innate and adaptive immunity are critical for effective protection against viruses. To counter this, some viruses have evolved…”
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CMV immunology by Jonjic, Stipan

“…Human cytomegalovirus （HCMV） is a ubiquitous pathogen linked to a high risk of morbidity in immunologically sup- pressed and immunodeficient patients, and it…”
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Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack by Gur, Chamutal, Ibrahim, Yara, Isaacson, Batya, Yamin, Rachel, Abed, Jawad, Gamliel, Moriya, Enk, Jonatan, Bar-On, Yotam, Stanietsky-Kaynan, Noah, Coppenhagen-Glazer, Shunit, Shussman, Noam, Almogy, Gideon, Cuapio, Angelica, Hofer, Erhard, Mevorach, Dror, Tabib, Adi, Ortenberg, Rona, Markel, Gal, Miklić, Karmela, Jonjic, Stipan, Brennan, Caitlin A, Garrett, Wendy S, Bachrach, Gilad, Mandelboim, Ofer

“…Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment. However, the immunological consequences of intra-tumoral bacteria remain…”
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The Interaction of TIGIT with PVR and PVRL2 Inhibits Human NK Cell Cytotoxicity by Stanietsky, Noa, Simic, Hrvoje, Arapovic, Jurica, Toporik, Amir, Levy, Ofer, Novik, Amit, Levine, Zurit, Beiman, Meirav, Dassa, Liat, Achdout, Hagit, Stern-Ginossar, Noam, Tsukerman, Pinhas, Jonjic, Stipan, Mandelboim, Ofer

“…NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are…”
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Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency by Ouwendijk, Werner J. D., Depledge, Daniel P., Rajbhandari, Labchan, Lenac Rovis, Tihana, Jonjic, Stipan, Breuer, Judith, Venkatesan, Arun, Verjans, Georges M. G. M., Sadaoka, Tomohiko

“…Varicella-zoster virus (VZV) establishes lifelong neuronal latency in most humans world-wide, reactivating in one-third to cause herpes zoster and occasionally…”
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NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection by Pallmer, Katharina, Barnstorf, Isabel, Baumann, Nicolas S, Borsa, Mariana, Jonjic, Stipan, Oxenius, Annette

“…Besides their function in recognizing cancerous and virally infected cells, natural killer (NK) cells have the potential to shape adaptive immune responses…”
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Immunobiology of congenital cytomegalovirus infection of the central nervous system--the murine cytomegalovirus model by Slavuljica, Irena, Kveštak, Daria, Csaba Huszthy, Peter, Kosmac, Kate, Britt, William J, Jonjić, Stipan

“…Congenital human cytomegalovirus infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and hearing…”
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Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells by Zaffran, Ilan, Landolina, Nadine, Gaur, Pratibha, Rovis, Tihana Lenac, Jonjic, Stipan, Mandelboim, Ofer, Singer, Bernhard B., Levi-Schaffer, Francesca

“…Inhibitory receptors (IRs), such as the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), are cell surface molecules expressed on both…”
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Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection by Nabekura, Tsukasa, Gotthardt, Dagmar, Niizuma, Kouta, Trsan, Tihana, Jenus, Tina, Jonjic, Stipan, Lanier, Lewis L

“…NK cells play a critical role in host defense against viruses. In this study, we investigated the role of NKG2D in the expansion of NK cells after mouse CMV…”
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Virus Progeny of Murine Cytomegalovirus Bacterial Artificial Chromosome pSM3fr Show Reduced Growth in Salivary Glands due to a Fixed Mutation of MCK-2 by JORDAN, Stefan, KRAUSE, Johannes, PRAGER, Adrian, MITROVIC, Maja, JONJIC, Stipan, KOSZINOWSKI, Ulrich H, ADLER, Barbara

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity by Reches, Adi, Ophir, Yael, Stein, Natan, Kol, Inbal, Isaacson, Batya, Charpak Amikam, Yoav, Elnekave, Afek, Tsukerman, Pinchas, Kucan Brlic, Paola, Lenac, Tihana, Seliger, Barbara, Jonjic, Stipan, Mandelboim, Ofer

“…BackgroundThe use of checkpoint inhibitors has revolutionized cancer therapy. Unfortunately, these therapies often cause immune-related adverse effects,…”
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IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection by Popovic, Branka, Golemac, Mijo, Podlech, Jürgen, Zeleznjak, Jelena, Bilic-Zulle, Lidija, Lukic, Miodrag L, Cicin-Sain, Luka, Reddehase, Matthias J, Sparwasser, Tim, Krmpotic, Astrid, Jonjic, Stipan

“…Regulatory T (Treg) cells dampen an exaggerated immune response to viral infections in order to avoid immunopathology. Cytomegaloviruses (CMVs) are…”
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Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality by Khaleafi, Raghad, Zeleznjak, Jelena, Cordela, Sapir, Drucker, Shani, Rovis, Tihana Lenac, Jonjic, Stipan, Bar-On, Yotam

“…In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which…”
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SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection by Chaouat, Abigael Eva, Achdout, Hagit, Kol, Inbal, Berhani, Orit, Roi, Gil, Vitner, Einat B, Melamed, Sharon, Politi, Boaz, Zahavy, Eran, Brizic, Ilija, Lenac Rovis, Tihana, Alfi, Or, Wolf, Dana, Jonjic, Stipan, Israely, Tomer, Mandelboim, Ofer

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Currently, as dangerous mutations emerge, there is an…”
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Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection by Karner, Dubravka, Kvestak, Daria, Kucan Brlic, Paola, Cokaric Brdovcak, Maja, Lisnic, Berislav, Brizic, Ilija, Juranic Lisnic, Vanda, Golemac, Mijo, Tomac, Jelena, Krmpotic, Astrid, Karkeni, Esma, Libri, Valentina, Mella, Sebastien, Legname, Giuseppe, Altmeppen, Hermann C., Hasan, Milena, Jonjic, Stipan, Lenac Rovis, Tihana

“…Cytomegalovirus (CMV) infection poses risks to newborns, necessitating effective therapies. Given that the damage includes both viral infection of brain cells…”
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Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo by Marcinowski, Lisa, Tanguy, Mélanie, Krmpotic, Astrid, Rädle, Bernd, Lisnić, Vanda J, Tuddenham, Lee, Chane-Woon-Ming, Béatrice, Ruzsics, Zsolt, Erhard, Florian, Benkartek, Corinna, Babic, Marina, Zimmer, Ralf, Trgovcich, Joanne, Koszinowski, Ulrich H, Jonjic, Stipan, Pfeffer, Sébastien, Dölken, Lars

“…Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent…”
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TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation by Worboys, Jonathan D., Vowell, Katherine N., Hare, Roseanna K., Ambrose, Ashley R., Bertuzzi, Margherita, Conner, Michael A., Patel, Florence P., Zammit, William H., Gali-Moya, Judit, Hazime, Khodor S., Jones, Katherine L., Rey, Camille, Jonjic, Stipan, Rovis, Tihana Lenac, Tannahill, Gillian M., Cruz De Matos, Gabriela Dos Santos, Waight, Jeremy D., Davis, Daniel M.

“…TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through…”
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Murine CMV-induced hearing loss is associated with inner ear inflammation and loss of spiral ganglia neurons by Bradford, Russell D, Yoo, Young-Gun, Golemac, Mijo, Pugel, Ester Pernjak, Jonjic, Stipan, Britt, William J

“…Congenital human cytomegalovirus (HCMV) occurs in 0.5-1% of live births and approximately 10% of infected infants develop hearing loss. The mechanism(s) of…”
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The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells by Lankry, Dikla, Rovis, Tihana Lenac, Jonjic, Stipan, Mandelboim, Ofer

“…The activity of NK cells is controlled by inhibitory and activating receptors. The inhibitory receptors interact mostly with MHC class I proteins, however,…”
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Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion by Angulo, Guillem, Zeleznjak, Jelena, Martínez-Vicente, Pablo, Puñet-Ortiz, Joan, Hengel, Hartmut, Messerle, Martin, Oxenius, Annette, Jonjic, Stipan, Krmpotić, Astrid, Engel, Pablo, Angulo, Ana

“…Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to…”
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