Search Results - "Jongeneel, Lieneke"

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion by van der Burgh, Robert, Nijhuis, Lotte, Pervolaraki, Kalliopi, Compeer, Ewoud B., Jongeneel, Lieneke H., van Gijn, Marielle, Coffer, Paul J., Murphy, Michael P., Mastroberardino, Pier G., Frenkel, Joost, Boes, Marianne

“…Most hereditary periodic fever syndromes are mediated by deregulated IL-1β secretion. The generation of mature IL-1β requires two signals: one that induces…”
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Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways by Butler, Miriam, Vervoort, Britt M.T., van Ingen Schenau, Dorette S., Jongeneel, Lieneke, van der Zwet, Jordy C.G., Marke, René, Meijerink, Jules P.P., Scheijen, Blanca, van der Meer, Laurens T., van Leeuwen, Frank N.

“…Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations,…”
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Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis by Shan, Liling, van den Hoogen, Lucas L, Meeldijk, Jan, Kok, Helena M, Jongeneel, Lieneke H, Boes, Marianne, Wenink, Mark H, Hack, C Erik, Radstake, Timothy R D J, van Roon, Joel A G, Bovenschen, Niels

“…Granzymes are serine proteases involved in eliminating tumour cells and virally infected cells. In addition, extracellular granzyme levels are elevated in…”
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Granzyme M and K release in human experimental endotoxemia by Wensink, Annette C, Wiewel, Maryse A, Jongeneel, Lieneke H, Boes, Marianne, van der Poll, Tom, Hack, C. Erik, Bovenschen, Niels

“…Abstract Granzymes are serine proteases involved in killing of tumor cells and virally infected cells. However, granzymes are also upregulated in blood under…”
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A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling by Flinsenberg, Thijs W.H, Janssen, Willemijn J, Herczenik, Eszter, Boross, Peter, Nederend, Maaike, Jongeneel, Lieneke H, Scholman, Rianne C, Boelens, Jaap-Jan, Maas, Coen, van Gijn, Marielle E, van Montfrans, Joris M, Leusen, Jeanette H, Boes, Marianne

“…Abstract We identified a novel Q27W FcγRIIa variant that was found more frequently in common variable immunodeficiency (CVID) or CVID-like children. We…”
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Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and 'click' conjugation by Branderhorst, Hilbert M, Kooij, Raymond, Salminen, Annika, Jongeneel, Lieneke H, Arnusch, Christopher J, Liskamp, Rob M J, Finne, Jukka, Pieters, Roland J

“…A galabiose disaccharide building block was synthesized by an efficient pectinase cleavage of polygalacturonic acid and subsequent chemical functional group…”
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Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) controls immune synapse stability in human T cells by Janssen, Willemijn J.M., Grobarova, Valeria, Leleux, Jardin, Jongeneel, Lieneke, van Gijn, Marielle, van Montfrans, Joris M., Boes, Marianne

“…Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) is a cytosolic adaptor protein involved with T-cell activation, differentiation, and…”
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Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease by van der Burgh, Robert, Meeldijk, Jan, Jongeneel, Lieneke, Frenkel, Joost, Bovenschen, Niels, van Gijn, Mariëlle, Boes, Marianne

“…Patients who suffer from autoinflammatory disease (AID) exhibit seemingly uncontrolled release of interleukin (IL)-1β. The presence of this inflammatory…”
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