Search Results - "Jongejan, Aldo"

Unraveling transcriptome dynamics in human spermatogenesis by Jan, Sabrina Z, Vormer, Tinke L, Jongejan, Aldo, Röling, Michael D, Silber, Sherman J, de Rooij, Dirk G, Hamer, Geert, Repping, Sjoerd, van Pelt, Ans M M

“…Spermatogenesis is a dynamic developmental process that includes stem cell proliferation and differentiation, meiotic cell divisions and extreme chromatin…”
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Neuroblastoma is composed of two super-enhancer-associated differentiation states by van Groningen, Tim, Koster, Jan, Valentijn, Linda J, Zwijnenburg, Danny A, Akogul, Nurdan, Hasselt, Nancy E, Broekmans, Marloes, Haneveld, Franciska, Nowakowska, Natalia E, Bras, Johannes, van Noesel, Carel J M, Jongejan, Aldo, van Kampen, Antoine H, Koster, Linda, Baas, Frank, van Dijk-Kerkhoven, Lianne, Huizer-Smit, Margriet, Lecca, Maria C, Chan, Alvin, Lakeman, Arjan, Molenaar, Piet, Volckmann, Richard, Westerhout, Ellen M, Hamdi, Mohamed, van Sluis, Peter G, Ebus, Marli E, Molenaar, Jan J, Tytgat, Godelieve A, Westerman, Bart A, van Nes, Johan, Versteeg, Rogier

“…Rogier Versteeg, Johan van Nes and colleagues report that neuroblastomas comprise two cell types, mesenchymal and adrenergic, that have different responses to…”
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A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways by Molenaars, Marte, Janssens, Georges E., Williams, Evan G., Jongejan, Aldo, Lan, Jiayi, Rabot, Sylvie, Joly, Fatima, Moerland, Perry D., Schomakers, Bauke V., Lezzerini, Marco, Liu, Yasmine J., McCormick, Mark A., Kennedy, Brian K., van Weeghel, Michel, van Kampen, Antoine H.C., Aebersold, Ruedi, MacInnes, Alyson W., Houtkooper, Riekelt H.

“…Slowing down translation in either the cytosol or the mitochondria is a conserved longevity mechanism. Here, we found a non-interventional natural correlation…”
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The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis by Kempers, Lanette, Wakayama, Yuki, van der Bijl, Ivo, Furumaya, Charita, De Cuyper, Iris M., Jongejan, Aldo, Kat, Marije, van Stalborch, Anne-Marieke D., van Boxtel, Antonius L., Hubert, Marvin, Geerts, Dirk, van Buul, Jaap D., de Korte, Dirk, Herzog, Wiebke, Margadant, Coert

“…Sprouting angiogenesis is key to many pathophysiological conditions, and is strongly regulated by vascular endothelial growth factor (VEGF) signaling through…”
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Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans by Liu, Yasmine J., Gao, Arwen W., Smith, Reuben L., Janssens, Georges E., Panneman, Daan M., Jongejan, Aldo, van Weeghel, Michel, Vaz, Frédéric M., Silvestrini, Melissa J., Lapierre, Louis R., MacInnes, Alyson W., Houtkooper, Riekelt H.

“…Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the…”
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Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion by Liu, Yasmine J, Janssens, Georges E, McIntyre, Rebecca L, Molenaars, Marte, Kamble, Rashmi, Gao, Arwen W, Jongejan, Aldo, Weeghel, Michel van, MacInnes, Alyson W, Houtkooper, Riekelt H

“…The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features…”
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Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation by van den Bosch, Aletta M. R., van der Poel, Marlijn, Fransen, Nina L., Vincenten, Maria C. J., Bobeldijk, Anneleen M., Jongejan, Aldo, Engelenburg, Hendrik J., Moerland, Perry D., Smolders, Joost, Huitinga, Inge, Hamann, Jörg

“…Microglia nodules (HLA-DR + cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first…”
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Clues for Polygenic Inheritance of Pituitary Stalk Interruption Syndrome From Exome Sequencing in 20 Patients by Zwaveling-Soonawala, Nitash, Alders, Marielle, Jongejan, Aldo, Kovačič, Lidija, Duijkers, Floor A, Maas, Saskia M, Fliers, Eric, van Trotsenburg, A S Paul, Hennekam, Raoul C

“…Abstract Context Pituitary stalk interruption syndrome (PSIS) consists of a small/absent anterior pituitary lobe, an interrupted/absent pituitary stalk, and an…”
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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans by Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam

“…The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified…”
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ENCORE: a practical implementation to improve reproducibility and transparency of computational research by van Kampen, Antoine H. C., Mahamune, Utkarsh, Jongejan, Aldo, van Schaik, Barbera D. C., Balashova, Daria, Lashgari, Danial, Pras-Raves, Mia, Wever, Eric J. M., Dane, Adrie D., García-Valiente, Rodrigo, Moerland, Perry D.

“…Reproducibility of computational research is often challenging despite established guidelines and best practices. Translating these guidelines into practical…”
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TRIB3 Modulates PPARγ-Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells by Hernández-Quiles, Miguel, Baak, Rosalie, Orea-Soufi, Alba, Borgman, Anouska, den Haan, Suzanne, Sobrevals Alcaraz, Paula, Jongejan, Aldo, van Es, Robert, Velasco, Guillermo, Vos, Harmjan, Kalkhoven, Eric

“…Aberrant expression or activity of proteins are amongst the best understood mechanisms that can drive cancer initiation and progression, as well as therapy…”
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The bivariate NRIP1/ZEB2 RNA marker permits non-invasive presymptomatic screening of pre-eclampsia by Manders, Vera, Visser, Allerdien, Keijser, Remco, Min, Naomi, Poutsma, Ankie, Mulders, Joyce, van den Berkmortel, Tarah, Hortensius, Marjolein, Jongejan, Aldo, Pajkrt, Eva, Sistermans, Erik A., Sie, Daoud, Best, Myron G., Würdinger, Tom, de Boer, Marjon, Afink, Gijs, Oudejans, Cees

“…Using genome-wide transcriptome analysis by RNA sequencing of first trimester plasma RNA, we tested whether the identification of pregnancies at risk of…”
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Neutrophil degranulation interconnects over-represented biological processes in atrial fibrillation by Kawasaki, Makiri, Meulendijks, Eva R., van den Berg, Nicoline W. E., Nariswari, Fransisca A., Neefs, Jolien, Wesselink, Robin, Baalman, Sarah W. E., Jongejan, Aldo, Schelfhorst, Tim, Piersma, Sander R., Pham, Thang V., van Boven, Wim J. P., Driessen, Antoine H. G., Jimenez, Connie R., de Groot, Joris R.

“…Despite our expanding knowledge about the mechanism underlying atrial fibrillation (AF), the interplay between the biological events underlying AF remains…”
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In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones by Musters, Anne, Klarenbeek, Paul L, Doorenspleet, Marieke E, Balzaretti, Giulia, Esveldt, Rebecca E E, van Schaik, Barbera D C, Jongejan, Aldo, Tas, Sander W, van Kampen, Antoine H C, Baas, Frank, de Vries, Niek

“…Genetic and immunological evidence clearly points to a role for T cells in the pathogenesis of rheumatoid arthritis (RA). Selective targeting of such…”
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Tat-dependent production of an HIV-1 TAR-encoded miRNA-like small RNA by Harwig, Alex, Jongejan, Aldo, van Kampen, Antoine H C, Berkhout, Ben, Das, Atze T

“…Evidence is accumulating that retroviruses can produce microRNAs (miRNAs). To prevent cleavage of their RNA genome, retroviruses have to use an alternative RNA…”
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Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4 by McIntyre, Rebecca L., Molenaars, Marte, Schomakers, Bauke V., Gao, Arwen W., Kamble, Rashmi, Jongejan, Aldo, van Weeghel, Michel, van Kuilenburg, André B.P., Possemato, Richard, Houtkooper, Riekelt H., Janssens, Georges E.

“…The human population is aging, and the need for interventions to slow progression of age-related diseases (geroprotective interventions) is growing…”
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Framing the potential of public frameshift peptides as immunotherapy targets in colon cancer by Spaanderman, Ide T, Peters, Fleur S, Jongejan, Aldo, Redeker, Egbert J. W, Punt, Cornelis J. A, Bins, Adriaan D

“…Approximately 15% of Colon Cancers are Microsatellite Instable (MSI). Frameshift Peptides (FPs) formed in MSI Colon Cancer are potential targets for…”
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Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity by Smith, Reuben L, Tan, Josephine M E, Jonker, Martijs J, Jongejan, Aldo, Buissink, Thomas, Veldhuijzen, Steve, van Kampen, Antoine H C, Brul, Stanley, van der Spek, Hans

“…Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their…”
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Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages by van Wouw, Suzanne A.E., van den Berg, Marlene, El Ouraoui, Maroua, Meurs, Amber, Kingma, Jenina, Ottenhoff, Roelof, Loix, Melanie, Hoeksema, Marten A., Prange, Koen, Pasterkamp, Gerard, Hendriks, Jerome J.A., Bogie, Jeroen F.J., van Klinken, Jan B., Vaz, Frederic M., Jongejan, Aldo, de Winther, Menno P.J., Zelcer, Noam

“…Lysoplasmalogens are a class of vinyl ether bioactive lipids that have a central role in plasmalogen metabolism and membrane fluidity. The liver X receptor…”
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In rheumatoid arthritis inflamed joints share dominant patient-specific B-cell clones by Musters, Anne, Balzaretti, Giulia, van Schaik, Barbera D. C., Jongejan, Aldo, van der Weele, Linda, Tas, Sander W., van Kampen, Antoine H. C., de Vries, Niek

“…Background In patients with rheumatoid arthritis (RA) different joints were shown to share the same dominant T-cell clones, suggesting shared characteristics…”
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