Search Results - "Jong, Igle J."

Effects of age and comorbidity on treatment and survival of patients with muscle‐invasive bladder cancer by Goossens‐Laan, Catharina A., Leliveld, Anna M., Verhoeven, Rob H.A., Kil, Paul J.M., Bock, Geertruida H., Hulshof, Maarten C.C.M., Jong, Igle J., Coebergh, Jan Willem W.

“…Our study assessed whether rising age, socioeconomic status (SES) and the presence of serious comorbidity affected treatment choice and survival in a…”
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Platinum exposure and cause‐specific mortality among patients with testicular cancer by Groot, Harmke J., Leeuwen, Flora E., Lubberts, Sjoukje, Horenblas, Simon, Wit, Ronald, Witjes, J. Alfred, Groenewegen, Gerard, Poortmans, Philip M., Hulshof, Maarten C. C. M., Meijer, Otto W. M., Jong, Igle J., Berg, Hetty A., Smilde, Tineke J., Vanneste, Ben G. L., Aarts, Maureen J. B., Jóźwiak, Katarzyna, Belt‐Dusebout, Alexandra W., Gietema, Jourik A., Schaapveld, Michael

“…Background Although testicular cancer (TC) treatment has been associated with severe late morbidities, including second malignant neoplasms (SMNs) and ischemic…”
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PSMA, EpCAM, VEGF and GRPR as imaging targets in locally recurrent prostate cancer after radiotherapy by Rybalov, Maxim, Ananias, Hildo J K, Hoving, Hilde D, van der Poel, Henk G, Rosati, Stefano, de Jong, Igle J

“…In this retrospective pilot study, the expression of the prostate-specific membrane antigen (PSMA), the epithelial cell adhesion molecule (EpCAM), the vascular…”
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Detection of local, regional, and distant recurrence in patients with psa relapse after external-beam radiotherapy using (11)C-choline positron emission tomography by Breeuwsma, Anthonius J, Pruim, Jan, van den Bergh, Alphons C M, Leliveld, Anna M, Nijman, Rien J M, Dierckx, Rudi A J O, de Jong, Igle J

“…An elevated serum prostate-specific antigen (PSA) level cannot distinguish between local-regional recurrences and the presence of distant metastases after…”
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An update of radiolabeled bombesin analogs for gastrin-releasing peptide receptor targeting by Yu, Zilin, Ananias, Hildo J K, Carlucci, Giuseppe, Hoving, Hilde D, Helfrich, Wijnand, Dierckx, Rudi A J O, Wang, Fan, de Jong, Igle J, Elsinga, Philip H

“…Prostate cancer is a critical public health problem in USA and Europe. New non-invasive imaging methods are urgently needed, due to the low accuracy and…”
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CXCR4 Inhibition with AMD3100 Sensitizes Prostate Cancer to Docetaxel Chemotherapy by Domanska, Urszula M, Timmer-Bosscha, Hetty, Nagengast, Wouter B, Oude Munnink, Thijs H, Kruizinga, Roeliene C, Ananias, Hildo J.K, Kliphuis, Nathalie M, Huls, Gerwin, De Vries, Elisabeth G.E, de Jong, Igle J, Walenkamp, Annemiek M.E

“…Abstract Several in vitro and in vivo models have revealed the key role of CXCR4/CXCL12 axis in tumor-stroma interactions. Stromal cells present in the tumor…”
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EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study by Campos, Anna K, Hoving, Hilde D, Rosati, Stefano, van Leenders, Geert J L H, de Jong, Igle J

“…There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive modality that can assess lymph node and bone metastases…”
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EpCAM Expression in Lymph Node Metastases of Urothelial Cell Carcinoma of the Bladder: A Pilot Study by van der Fels, Christa A M, Rosati, Stefano, de Jong, Igle J

“…In this retrospective pilot study, the feasibility of the epithelial cell adhesion molecule (EpCAM) as an imaging target for lymph node (LN) metastatic disease…”
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Multimerization improves targeting of peptide radio-pharmaceuticals by Carlucci, Giuseppe, Ananias, Hildo J K, Yu, Zilin, Van de Wiele, Christophe, Dierckx, Rudi A, de Jong, Igle J, Elsinga, Philip H

“…Multimerization offers unique kinetic and thermodynamic properties to molecules. Multimeric ligands, characterized by multiple similar or different monomeric…”
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Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis by Bigaeva, Emilia, Puerta Cavanzo, Nataly, Stribos, Elisabeth G D, de Jong, Amos J, Biel, Carin, Mutsaers, Henricus A M, Jensen, Michael S, Nørregaard, Rikke, Leliveld, Anna M, de Jong, Igle J, Hillebrands, Jan-Luuk, van Goor, Harry, Boersema, Miriam, Bank, Ruud A, Olinga, Peter

“…Animal models are a valuable tool in preclinical research. However, limited predictivity of human biological responses in the conventional models has…”
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Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin β-subunit and pituitary gonadal hormones by de Bruin, Daphne, M.D, de Jong, Igle J., M.D., Ph.D, Arts, Eugène G.J.M., Ph.D, Nuver, Janine, M.D., Ph.D, Dullaart, Robin P.F., M.D., Ph.D, Sluiter, Willem J., Ph.D, Hoekstra, Harald J., M.D., Ph.D, Sleijfer, Dirk T., M.D., Ph.D, Gietema, Jourik A., M.D., Ph.D

“…Objective To compare the semen quality and hormonal status between patients with testicular cancer and normal versus increased serum levels of β-hCG. Design…”
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Clinical activity and tolerability of enzalutamide (MDV3100) in patients with metastatic, castration‐resistant prostate cancer who progress after docetaxel and abiraterone treatment by Badrising, Sushil, van der Noort, Vincent, van Oort, Inge M., van den Berg, H. Pieter, Los, Maartje, Hamberg, Paul, Coenen, Jules L., van den Eertwegh, Alfons J. M., de Jong, Igle J., Kerver, Emile D., van Tinteren, Harm, Bergman, Andries M.

“…BACKGROUND Enzalutamide (Enz) and abiraterone acetate (AA) are hormone treatments that have a proven survival advantage in patients with metastatic,…”
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Risk of Solid Cancer After Treatment of Testicular Germ Cell Cancer in the Platinum Era by Groot, Harmke J, Lubberts, Sjoukje, de Wit, Ronald, Witjes, Johannes A, Kerst, Jan Martijn, de Jong, Igle J, Groenewegen, Gerard, van den Eertwegh, Alfons J M, Poortmans, Philip M, Klümpen, Heinz-Josef, van den Berg, Hetty A, Smilde, Tineke J, Vanneste, Ben G L, Aarts, Maureen J, Incrocci, Luca, van den Bergh, Alfons C M, Jóźwiak, Katarzyna, van den Belt-Dusebout, Alexandra W, Horenblas, Simon, Gietema, Jourik A, van Leeuwen, Flora E, Schaapveld, Michael

“…Purpose Testicular cancer (TC) treatment increases risk of subsequent malignant neoplasms (SMNs). It is unknown whether changes in TC treatment over time have…”
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Surgical Safety of Cytoreductive Nephrectomy Following Sunitinib: Results from the Multicentre, Randomised Controlled Trial of Immediate Versus Deferred Nephrectomy (SURTIME) by De Bruijn, Roderick Emile, Mulders, Peter, Jewett, Michael A., Wagstaff, John, Van Thienen, Johan V., Blank, Christian U., Van Velthoven, Roland, Wood, Lori, van Melick, Harm E., Aarts, Maureen J., Lattouf, Jean B., Powles, Thomas, De Jong, Igle J., Rottey, Sylvie, Tombal, Betrand, Marreaud, Sandrine, Collette, Sandra, Collette, Laurence, Haanen, John B., Bex, Axel

“…The European Organisation for Research and Treatment of Cancer SURTIME trial explored timing of sunitinib, a tyrosine kinase inhibitor (TKI), and cytoreductive…”
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Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis by Bigaeva, Emilia, Stribos, Elisabeth G D, Mutsaers, Henricus A M, Piersma, Bram, Leliveld, Anna M, de Jong, Igle J, Bank, Ruud A, Seelen, Marc A, van Goor, Harry, Wollin, Lutz, Olinga, Peter, Boersema, Miriam

“…Poor translation from animal studies to human clinical trials is one of the main hurdles in the development of new drugs. Here, we used precision-cut kidney…”
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High risk bladder cancer: current management and survival by Leliveld, Anna M, Bastiaannet, Esther, Doornweerd, Benjamin H J, Schaapveld, Michael, de Jong, Igle J

“…To evaluate the pattern of care in patients with high risk non muscle invasive bladder cancer (NMIBC) in the Comprehensive Cancer Center North-Netherlands…”
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Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer by Ananias, Hildo J.K., van den Heuvel, Marius C., Helfrich, Wijnand, de Jong, Igle J.

“…OBJECTIVE Cell membrane antigens like the gastrin‐releasing peptide receptor (GRPR), the prostate stem cell antigen (PSCA), and the prostate‐specific membrane…”
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Synthesis and Evaluation of 18 F-Enzalutamide, a New Radioligand for PET Imaging of Androgen Receptors: A Comparison with 16β- 18 F-Fluoro-5α-Dihydrotestosterone by Antunes, Inês F, Dost, Rutger J, Hoving, Hilde D, van Waarde, Aren, Dierckx, Rudi A J O, Samplonius, Douwe F, Helfrich, Wijnand, Elsinga, Philip H, de Vries, Erik F J, de Jong, Igle J

“…16β- F-fluoro-5α-dihydrotestosterone ( F-FDHT) is a radiopharmaceutical that has been investigated as a diagnostic agent for the assessment of androgen…”
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Change in telomere length and cardiovascular risk factors in testicular cancer survivors by Volders, Ellen L D, Meijer, Coby, Steeneken, Lotte S, Lubberts, Sjoukje, Zwart, Nynke, van Roon, Arie M, Lefrandt, Joop D, de Jong, Igle J, Demaria, M, Nuver, Janine, Gietema, Jourik A

“…Testicular cancer (TC) survivors cured with chemotherapy (CT) are prone to develop cardiovascular diseases, as part of an accelerated aging phenotype. A…”
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Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis by Stribos, Elisabeth G.D, Luangmonkong, Theerut, Leliveld, Anna M, de Jong, Igle J, van Son, Willem J, Hillebrands, Jan-Luuk, Seelen, Marc A, van Goor, Harry, Olinga, Peter, Mutsaers, Henricus A.M

“…Chronic kidney disease is a major health concern, and experimental models bridging the gap between animal studies and clinical research are currently lacking…”
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