Search Results - "Jones Lipinski, Rachel A."

Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans by Zhou, Yue, Wang, Yuting, Zhang, Xinxing, Bhar, Subhradeep, Jones Lipinski, Rachel A, Han, Jungsoo, Feng, Likui, Butcher, Rebecca A

“…produces ascaroside pheromones to control its development and behavior. Even minor structural differences in the ascarosides have dramatic consequences for…”
Get full text

Molecular docking‐guided synthesis of NSAID–glucosamine bioconjugates and their evaluation as COX‐1/COX‐2 inhibitors with potentially reduced gastric toxicity by Jones Lipinski, Rachel A., Thillier, Yann, Morisseau, Christophe, Sebastiano, Christopher S., Smith, Brian C., Hall, C. Dennis, Katritzky, Alan R.

“…Non‐steroidal anti‐inflammatory drugs (NSAIDs) are a powerful class of inhibitors targeting two isoforms of the family of cyclooxygenase enzymes (COX‐1 and…”
Get full text

N- terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells by Nord, Joshua A, Wynia-Smith, Sarah L, Gehant, Alyssa L, Jones Lipinski, Rachel A, Naatz, Aaron, Rioja, Inmaculada, Prinjha, Rab K, Corbett, John A, Smith, Brian C

“…Chronic inflammation of pancreatic islets is a key driver of β-cell damage that can lead to autoreactivity and the eventual onset of autoimmune diabetes (T1D)…”
Get full text

Inhibition of Sirtuin Deacylase Activity by Peroxynitrite by Bohl, Kelsey, Wynia-Smith, Sarah L., Jones Lipinski, Rachel A., Smith, Brian C.

“…Sirtuins are a class of enzymes that deacylate protein lysine residues using NAD+ as a cosubstrate. Sirtuin deacylase activity has been historically regarded…”
Get full text

SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates by Waas, Matthew, Snarrenberg, Shana T, Littrell, Jack, Jones Lipinski, Rachel A, Hansen, Polly A, Corbett, John A, Gundry, Rebekah L

“…Abstract Motivation Cell-type-specific surface proteins can be exploited as valuable markers for a range of applications including immunophenotyping live…”
Get full text

SP2: Rapid and Automatable Contaminant Removal from Peptide Samples for Proteomic Analyses by Waas, Matthew, Pereckas, Michaela, Jones Lipinski, Rachel A., Ashwood, Christopher, Gundry, Rebekah L.

“…Peptide cleanup is essential for the removal of contaminating substances that may be introduced during sample preparation steps in bottom-up proteomic…”
Get full text

Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths by Zhang, Xinxing, Wang, Yuting, Perez, David H, Jones Lipinski, Rachel A, Butcher, Rebecca A

“…Caenorhabditis elegans produces a complex mixture of ascaroside pheromones to control its development and behavior. Acyl-CoA oxidases, which participate in…”
Get full text

Discovery and characterization of halogenated xanthene inhibitors of DUSP5 as potential photodynamic therapeutics by Bongard, Robert D., Lepley, Michael, Gastonguay, Adam, Syrlybaeva, Raulia R., Talipov, Marat R., Jones Lipinski, Rachel A., Leigh, Noah R., Brahmbhatt, Jaladhi, Kutty, Raman, Rathore, Rajendra, Ramchandran, Ramani, Sem, Daniel S.

“…[Display omitted] •Xanthene-ring analogs all inhibit DUSP5 in vitro, with relative potencies: rose bengal > merbromin > erythrosin B > eosin Y.•Inhibition is…”
Get full text

Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor by Bongard, Robert D, Lepley, Michael, Thakur, Khushabu, Talipov, Marat R, Nayak, Jaladhi, Lipinski, Rachel A Jones, Bohl, Chris, Sweeney, Noreena, Ramchandran, Ramani, Rathore, Rajendra, Sem, Daniel S

“…Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that…”
Get full text

2131-P: BET Bromodomain Inhibition Upregulates SIRT1 In Pancreatic ß-Cells by JONES LIPINSKI, RACHEL A., WYNIA-SMITH, SARAH, NORD, JOSHUA, SMITH, BRIAN C.

“…Diabetes develops as a result of both genetic and environmental influences; however, low concordance rates of type 1 diabetes between monozygotic twins and…”
Get full text

Zinc‐Chelating BET Bromodomain Inhibitors Selectively Accumulate and Affect Gene Expression in Pancreatic β‐Cells by Jones Lipinski, Rachel A., Stancill, Jennifer S., Wynia‐Smith, Sarah L., Sprague, Daniel J., Nunez, Raymundo, Bird, Amir, Corbett, John A., Smith, Brian C.

“…The islets of Langerhans are a heterogeneous mixture of endocrine (hormone‐secreting) cells in the mammalian pancreas. Of particular interest are the β‐cells…”
Get full text

Dual Specificity Phosphatase 5-Substrate Interaction: A Mechanistic Perspective by Kutty, Raman G, Talipov, Marat R, Bongard, Robert D, Lipinski, Rachel A Jones, Sweeney, Noreena L, Sem, Daniel S, Rathore, Rajendra, Ramchandran, Ramani

“…The mammalian genome contains approximately 200 phosphatases that are responsible for catalytically removing phosphate groups from proteins. In this review, we…”
Get more information