Search Results - "Jones, Simon S"

Ricolinostat plus lenalidomide, and dexamethasone in relapsed or refractory multiple myeloma: a multicentre phase 1b trial by Yee, Andrew J, MD, Bensinger, William I, MD, Supko, Jeffrey G, PhD, Voorhees, Peter M, MD, Berdeja, Jesus G, MD, Richardson, Paul G, Prof, Libby, Edward N, MD, Wallace, Ellen E, BA, Birrer, Nicole E, BA, Burke, Jill N, MSN, Tamang, David L, PhD, Yang, Min, PhD, Jones, Simon S, PhD, Wheeler, Catherine A, MD, Markelewicz, Robert J, MD, Raje, Noopur S, Dr

“…Summary Background Histone deacetylase (HDAC) inhibitors are an important new class of therapeutics for treating multiple myeloma. Ricolinostat (ACY-1215) is…”
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Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models by Huang, Pengyu, Almeciga-Pinto, Ingrid, Jarpe, Matthew, van Duzer, John H, Mazitschek, Ralph, Yang, Min, Jones, Simon S, Quayle, Steven N

“…ACY-241 is a novel, orally available and selective histone deacetylase (HDAC) 6 inhibitor in Phase 1b clinical development in multiple myeloma (NCT 02400242)…”
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Ricolinostat (ACY‐1215) induced inhibition of aggresome formation accelerates carfilzomib‐induced multiple myeloma cell death by Mishima, Yuko, Santo, Loredana, Eda, Homare, Cirstea, Diana, Nemani, Neeharika, Yee, Andrew J., O'Donnell, Elizabeth, Selig, Martin Karl, Quayle, Steven N., Arastu‐Kapur, Shirin, Kirk, Christopher, Boise, Lawrence H., Jones, Simon S., Raje, Noopur

“…Summary Proteasome inhibition induces the accumulation of aggregated misfolded/ubiquitinated proteins in the aggresome; conversely, histone deacetylase 6…”
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Enhancement of pomalidomide anti-tumor response with ACY-241, a selective HDAC6 inhibitor by North, Brian J, Almeciga-Pinto, Ingrid, Tamang, David, Yang, Min, Jones, Simon S, Quayle, Steven N

“…Thalidomide-based Immunomodulatory Drugs (IMiDs®), including lenalidomide and pomalidomide, are effective therapeutics for multiple myeloma. These agents have…”
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Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2 by Shearstone, Jeffrey R, Golonzhka, Olga, Chonkar, Apurva, Tamang, David, van Duzer, John H, Jones, Simon S, Jarpe, Matthew B

“…Therapeutic intervention aimed at reactivation of fetal hemoglobin protein (HbF) is a promising approach for ameliorating sickle cell disease (SCD) and…”
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HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model by Maharaj, Kamira, Powers, John J, Mediavilla-Varela, Melanie, Achille, Alex, Gamal, Wael, Quayle, Steven, Jones, Simon S, Sahakian, Eva, Pinilla-Ibarz, Javier

“…Development of chronic lymphocytic leukemia (CLL) is associated with severe immune dysfunction. T-cell exhaustion, immune checkpoint upregulation, and increase…”
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In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-Hodgkin lymphoma cells by Dasmahapatra, Girija, Patel, Hiral, Friedberg, Johnathan, Quayle, Steven N, Jones, Simon S, Grant, Steven

“…Interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib were examined in non-Hodgkin lymphoma…”
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Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia by Min, Chengyin, Moore, Nathan, Shearstone, Jeffrey R, Quayle, Steven N, Huang, Pengyu, van Duzer, John H, Jarpe, Matthew B, Jones, Simon S, Yang, Min

“…Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic stem cell disorders characterized by defects in myeloid differentiation and increased…”
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The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats by Mohler, Eric G., Baker, Phillip M., Gannon, Kimberly S., Jones, Simon S., Shacham, Sharon, Sweeney, John A., Ragozzino, Michael E.

“…Rationale Accumulating evidence indicates that schizophrenia and autism spectrum disorder patients are marked by cognitive deficits in working memory and…”
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Ricolinostat, the First Selective Histone Deacetylase 6 Inhibitor, in Combination with Bortezomib and Dexamethasone for Relapsed or Refractory Multiple Myeloma by Vogl, Dan T, Raje, Noopur, Jagannath, Sundar, Richardson, Paul, Hari, Parameswaran, Orlowski, Robert, Supko, Jeffrey G, Tamang, David, Yang, Min, Jones, Simon S, Wheeler, Catherine, Markelewicz, Robert J, Lonial, Sagar

“…Histone deacetylase (HDAC) inhibition improves the efficacy of proteasome inhibition for multiple myeloma but adds substantial toxicity. Preclinical models…”
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Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma by Santo, Loredana, Hideshima, Teru, Kung, Andrew L., Tseng, Jen-Chieh, Tamang, David, Yang, Min, Jarpe, Matthew, van Duzer, John H., Mazitschek, Ralph, Ogier, Walter C., Cirstea, Diana, Rodig, Scott, Eda, Homare, Scullen, Tyler, Canavese, Miriam, Bradner, James, Anderson, Kenneth C., Jones, Simon S., Raje, Noopur

“…Histone deacetylase (HDAC) enzymatic activity has been linked to the transcription of DNA in cancers including multiple myeloma (MM). Therefore, HDAC…”
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Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC by Mithraprabhu, Sridurga, Khong, Tiffany, Jones, Simon S., Spencer, Andrew

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Retraction: In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells by Dasmahapatra, Girija, Patel, Hiral, Friedberg, Johnathan, Quayle, Steven N, Jones, Simon S, Grant, Steven

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Abstract 3958: Tubulin hyper-acetylation in blood lymphocytes: pharmacodynamic (PD) biomarker for the selective histone deacetylase (HDAC) 6 inhibitors ricolinostat and ACY-241 in multiple myeloma (MM) patients by Tamang, David L., Supko, Jeffery, Bhol, Kailash, Wheeler, Catherine, Jones, Simon S., Yang, Min

“…Abstract INTRODUCTION: HDACs are a family of enzymes that remove acetyl groups from proteins and are involved in key cellular processes. Nonselective HDAC…”
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Abstract 4724: Novel and selective inhibitors of histone deacetylases (HDAC) 1 and 2 synergize with DNA methyltransferase inhibitor azacitidine in acute myeloid leukemia (AML) by Min, Chengyin, Quayle, Steven N., Huang, Pengyu, Shearstone, Jeffrey R., Jones, Simon S., Yang, Min

“…Abstract AML is a heterogeneous group of hematopoietic stem cell disorders characterized by defects in myeloid differentiation and increased proliferation of…”
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Abstract 4485: Regulation of chronic lymphocytic leukemia (CLL) immunobiology by histone deacetylase 6 (HDAC6) by Sahakian, Eva, Maharaj, Kamira, Powers, John, Fonesca, Renee M., Deng, Susan, Pinilla-Ibraz, Javier, Quayle, Steven N., Jones, Simon S.

“…Abstract In CLL, an immunosuppressive phenotype enables the malignant B cell to evade immune detection leading to immune suppression. In recent years,…”
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Abstract 2477: An orally bioavailable and selective histone deacetylase (HDAC) 1 & 2 inhibitor enhances retinoic acid mediated differentiation of neuroblastoma by Tamang, David L., Huang, Pengyu, Golonzhka, Olga, Shearstone, Jeffrey R., Quayle, Steven N., Jones, Simon S., Yang, Min

“…Abstract INTRODUCTION: Neuroblastoma (NB) is an extra-cranial solid cancer and is among the most common cancers in infants less than 1 year of age, with 650…”
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BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells by GOULD, Stephen E, DAY, Maria, JONES, Simon S, DORAI, Haimanti

“…Proximal tubule epithelial cells (PTEC) play a central role in the response of the kidney to insult by virtue of their production of chemokines and cytokines…”
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Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia by Maharaj, Kamira, Powers, John J., Achille, Alex, Deng, Susan, Fonseca, Renee, Pabon-Saldana, Mibel, Quayle, Steven N., Jones, Simon S., Villagra, Alejandro, Sotomayor, Eduardo M., Sahakian, Eva, Pinilla-Ibarz, Javier

“…Although the treatment paradigm for chronic lymphocytic leukemia (CLL) is rapidly changing, the disease remains incurable, except with allogeneic bone marrow…”
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Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins by Wong, Gordon G., Witek, JoAnn S., Temple, Patricia A., Wilkens, Kathleen M., Leary, Anne C., Luxenberg, Deborah P., Jones, Simon S., Brown, Eugene L., Kay, Robert M., Orr, Elizabeth C., Shoemaker, Charles, Golde, David W., Kaufman, Randal J., Hewick, Rodney M., Wang, Elizabeth A., Clark, Steven C.

“…Clones of complementary DNA encoding the human lymphokine known as granulocyte-macrophage colony-stimulating factor (GM-CSF) were isolated by means of a…”
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