Search Results - "Jones, Roland S. G."

A Low Mortality, High Morbidity Reduced Intensity Status Epilepticus (RISE) Model of Epilepsy and Epileptogenesis in the Rat by Modebadze, Tamara, Morgan, Nicola H, Pérès, Isabelle A A, Hadid, Rebecca D, Amada, Naoki, Hill, Charlotte, Williams, Claire, Stanford, Ian M, Morris, Christopher M, Jones, Roland S G, Whalley, Benjamin J, Woodhall, Gavin L

“…Animal models of acquired epilepsies aim to provide researchers with tools for use in understanding the processes underlying the acquisition, development and…”
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Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site by Lench, Alex M, Robson, Emma, Jones, Roland S G

“…Partial agonists at the NMDA receptor co-agonist binding site may have potential therapeutic efficacy in a number of cognitive and neurological conditions. The…”
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Tonic Facilitation of Glutamate Release by Presynaptic NR2B-Containing NMDA Receptors Is Increased in the Entorhinal Cortex of Chronically Epileptic Rats by Yang, Jian, Woodhall, Gavin L, Jones, Roland S. G

“…We have shown previously that when postsynaptic NMDA receptors are blocked, the frequency, but not amplitude, of spontaneous EPSCs (sEPSCs) at synapses in the…”
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Human brain slices for epilepsy research: Pitfalls, solutions and future challenges by Jones, Roland S.G., da Silva, Anderson Brito, Whittaker, Roger G., Woodhall, Gavin L., Cunningham, Mark O.

“…•Electrophysiology in human epilepsy samples gives unique insights into pharmacoresistant epilepsy.•A number of technical and logistical considerations…”
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Mobility of NMDA autoreceptors but not postsynaptic receptors at glutamate synapses in the rat entorhinal cortex by Yang, Jian, Chamberlain, Sophie E. L., Woodhall, Gavin L., Jones, Roland S. G.

“…NMDA receptors (NMDAr) are known to undergo recycling and lateral diffusion in postsynaptic spines and dendrites. However, NMDAr are also present as…”
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The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia by Brito da Silva, Anderson, Pennifold, Jane, Henley, Ben, Chatterjee, Koustav, Bateman, David, Whittaker, Roger W., Joshi, Abhijit, Kumar, Hrishikesh, Nicholson, Claire, Baker, Mark R., Greenhill, Stuart D., Walsh, Richard, Seri, Stefano, Jones, Roland S. G., Woodhall, Gavin L., Cunningham, Mark O.

“…Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical…”
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Neurokinin-receptor-mediated depolarization of cortical neurons elicits an increase in glutamate release at excitatory synapses by Stacey, Anne E., Woodhall, Gavin L., Jones, Roland S. G.

“…Using whole‐cell patch‐clamp recordings of spontaneous synaptic activity, we have previously shown that activation of neurokinin‐1 (NK1) but not NK3 receptors…”
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Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro by Cunningham, Mark O., Woodhall, Gavin L., Thompson, Sarah E., Dooley, David J., Jones, Roland S. G.

“…We have recently shown that the anticonvulsant drugs phenytoin, lamotrigine and sodium valproate all reduce the release of glutamate at synapses in the…”
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The pilocarpine model of temporal lobe epilepsy by Curia, Giulia, Longo, Daniela, Biagini, Giuseppe, Jones, Roland S.G., Avoli, Massimo

“…Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the…”
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Astroglial d-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex by Lench, Alex M., Massey, Peter V., Pollegioni, Loredano, Woodhall, Gavin L., Jones, Roland S.G.

“…Presynaptic NMDA receptors facilitate the release of glutamate at excitatory cortical synapses and are involved in regulation of synaptic dynamics and…”
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The Role of NMDA Receptor Subtypes in Short-Term Plasticity in the Rat Entorhinal Cortex by Chamberlain, Sophie E. L., Yang, Jian, Jones, Roland S. G.

“…We have previously shown that spontaneous release of glutamate in the entorhinal cortex (EC) is tonically facilitated via activation of presynaptic NMDA…”
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Ethosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release by Greenhill, Stuart D., Morgan, Nicola H., Massey, Peter V., Woodhall, Gavin L., Jones, Roland S.G.

“…Ethosuximide is the drug of choice for treating generalized absence seizures, but its mechanism of action is still a matter of debate. It has long been thought…”
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Neuronal Plasticity in the Entorhinal Cortex by Chapman, C. Andrew, Jones, Roland S. G., Jung, Min

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NR2B-Containing NMDA Autoreceptors at Synapses on Entorhinal Cortical Neurons by Woodhall, Gavin, Evans, D. Ieuan, Cunningham, Mark O, Jones, Roland S. G

“…Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom Woodhall, Gavin, D. Ieuan Evans, Mark O…”
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Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex by Yang, Jian, Wetterstrand, Caroline, Jones, Roland S.G

“…Summary We have shown that a number of anticonvulsant drugs can reduce glutamate release at synapses in the rat entorhinal cortex (EC) in vitro . We have also…”
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Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors by Jones, Roland S G, Woodhall, Gavin L

“…The entorhinal cortex (EC) is a key brain area controlling both hippocampal input and output via neurones in layer II and layer V, respectively. It is also a…”
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Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons by Prokic, Emma J., Weston, Cathryn, Yamawaki, Naoki, Hall, Stephen D., Jones, Roland S.G., Stanford, Ian M., Ladds, Graham, Woodhall, Gavin L.

“…Tonic conductance mediated by extrasynaptic GABAA receptors has been implicated in the modulation of network oscillatory activity. Using an in vitro brain…”
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Pre- and post-synaptic functions of kainate receptors at glutamate and GABA synapses in the rat entorhinal cortex by Chamberlain, Sophie E.L., Jane, David E., Jones, Roland S.G.

“…Oscillatory network activity in cortical areas is seen as vital to physiological processes of cognition, learning, and memory, and fundamental to disorders…”
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Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro by Cunningham, Mark O., Woodhall, Gavin L., Jones, Roland S.G.

“…The anticonvulsant, valproic acid (VPA), has a very wide spectrum of clinical activity and has conventionally been considered to act by enhancing inhibitory…”
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SYMPOSIUM REPORT. Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors by Jones, Roland S. G., Woodhall, Gavin L.

“…The entorhinal cortex (EC) is a key brain area controlling both hippocampal input and output via neurones in layer II and layer V, respectively. It is also a…”
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