Search Results - "Jones, Rheinallt"

The gut-bone axis: how bacterial metabolites bridge the distance by Zaiss, Mario M, Jones, Rheinallt M, Schett, Georg, Pacifici, Roberto

“…The gut microbiome is a key regulator of bone health that affects postnatal skeletal development and skeletal involution. Alterations in microbiota composition…”
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Redox signaling mediated by the gut microbiota by Jones, Rheinallt M., Neish, Andrew S.

“…The microbiota that inhabits the mammalian intestine can influence a range of physiological functions, including the modulation of immune responses,…”
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Gut Microbiota in Intestinal and Liver Disease by Jones, Rheinallt M, Neish, Andrew S

“…It is known that the gut microbiota, the numerically vast and taxonomically diverse microbial communities that thrive in a symbiotic fashion within our…”
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Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics by Li, Jau-Yi, Chassaing, Benoit, Tyagi, Abdul Malik, Vaccaro, Chiara, Luo, Tao, Adams, Jonathan, Darby, Trevor M, Weitzmann, M Neale, Mulle, Jennifer G, Gewirtz, Andrew T, Jones, Rheinallt M, Pacifici, Roberto

“…A eubiotic microbiota influences many physiological processes in the metazoan host, including development and intestinal homeostasis. Here, we have shown that…”
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Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation by Chen, Chun, Liao, Jianming, Xia, Yiyuan, Liu, Xia, Jones, Rheinallt, Haran, John, McCormick, Beth, Sampson, Timothy Robert, Alam, Ashfaqul, Ye, Keqiang

“…This study is to investigate the role of gut dysbiosis in triggering inflammation in the brain and its contribution to Alzheimer's disease (AD) pathogenesis…”
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Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging by Powell, Domonica N., Swimm, Alyson, Sonowal, Robert, Bretin, Alexis, Gewirtz, Andrew T., Jones, Rheinallt M., Kalman, Daniel

“…The intestinal epithelium is a highly dynamic structure that rejuvenates in response to acute stressors and can undergo alterations in cellular composition as…”
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Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury by Saeedi, Bejan J., Liu, Ken H., Owens, Joshua A., Hunter-Chang, Sarah, Camacho, Mary C., Eboka, Richard U., Chandrasekharan, Bindu, Baker, Nusaiba F., Darby, Trevor M., Robinson, Brian S., Jones, Rheinallt M., Jones, Dean P., Neish, Andrew S.

“…Many studies have suggested a role for gut-resident microbes (the “gut microbiome”) in modulating host health; however, the mechanisms by which they impact…”
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Osteomicrobiology: The influence of gut microbiota on bone in health and disease by Jones, Rheinallt M, Mulle, Jennifer G, Pacifici, Roberto

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The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression by Tyagi, Abdul Malik, Yu, Mingcan, Darby, Trevor M., Vaccaro, Chiara, Li, Jau-Yi, Owens, Joshua A., Hsu, Emory, Adams, Jonathan, Weitzmann, M. Neale, Jones, Rheinallt M., Pacifici, Roberto

“…Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we examined the impact of supplementation with Lactobacillus rhamnosus GG…”
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The Influence of the Gut Microbiota on Host Physiology: In Pursuit of Mechanisms by Jones, Rheinallt M

“…The results generated from the NIH funded Human Microbiome Project (HMP) are necessarily tied to the overall mission of the agency, which is to foster…”
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Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota by Li, Jau-Yi, Yu, Mingcan, Pal, Subhashis, Tyagi, Abdul Malik, Dar, Hamid, Adams, Jonathan, Weitzmann, M Neale, Jones, Rheinallt M, Pacifici, Roberto

“…Parathyroid hormone (PTH) is a critical regulator of skeletal development that promotes both bone formation and bone resorption. Using microbiota depletion by…”
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Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway by Jones, Rheinallt M., Desai, Chirayu, Darby, Trevor M., Luo, Liping, Wolfarth, Alexandra A., Scharer, Christopher D., Ardita, Courtney S., Reedy, April R., Keebaugh, Erin S., Neish, Andrew S.

“…An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in…”
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PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells by Yu, Mingcan, Malik Tyagi, Abdul, Li, Jau-Yi, Adams, Jonathan, Denning, Timothy L., Weitzmann, M. Neale, Jones, Rheinallt M., Pacifici, Roberto

“…Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone…”
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Callus γδ T cells and microbe-induced intestinal Th17 cells improve fracture healing in mice by Dar, Hamid Y, Perrien, Daniel S, Pal, Subhashis, Stoica, Andreea, Uppuganti, Sasidhar, Nyman, Jeffry S, Jones, Rheinallt M, Weitzmann, M Neale, Pacifici, Roberto

“…IL-17A (IL-17), a driver of the inflammatory phase of fracture repair, is produced locally by several cell lineages including γδ T cells and Th17 cells…”
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Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species by Jones, Rheinallt M, Luo, Liping, Ardita, Courtney S, Richardson, Arena N, Kwon, Young Man, Mercante, Jeffrey W, Alam, Ashfaqul, Gates, Cymone L, Wu, Huixia, Swanson, Phillip A, Lambeth, J David, Denning, Patricia W, Neish, Andrew S

“…The resident prokaryotic microbiota of the metazoan gut elicits profound effects on the growth and development of the intestine. However, the molecular…”
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The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone by Pal, Subhashis, Perrien, Daniel S, Yumoto, Tetsuya, Faccio, Roberta, Stoica, Andreea, Adams, Jonathan, Coopersmith, Craig M, Jones, Rheinallt M, Weitzmann, M Neale, Pacifici, Roberto

“…Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by…”
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Commensal microbiota-induced redox signaling activates proliferative signals in the intestinal stem cell microenvironment by Reedy, April R, Luo, Liping, Neish, Andrew S, Jones, Rheinallt M

“…A distinct taxon of the microbiota, , is capable of stimulating the generation of reactive oxygen species (ROS) within cells, and inducing epithelial cell…”
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Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet by Naudin, Crystal R., Maner-Smith, Kristal, Owens, Joshua A., Wynn, Grace M., Robinson, Brian S., Matthews, Jason D., Reedy, April R., Luo, Liping, Wolfarth, Alexandra A., Darby, Trevor M., Ortlund, Eric A., Jones, Rheinallt M.

“…A Western-style diet, which is high in fat and sugar, can cause significant dyslipidemia and nonalcoholic fatty liver disease; the diet has an especially…”
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The microenvironment of injured murine gut elicits a local pro-restitutive microbiota by Alam, Ashfaqul, Leoni, Giovanna, Quiros, Miguel, Wu, Huixia, Desai, Chirayu, Nishio, Hikaru, Jones, Rheinallt M., Nusrat, Asma, Neish, Andrew S.

“…The mammalian intestine houses a complex microbial community, which influences normal epithelial growth and development, and is integral to the repair of…”
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Immune Cell Isolation from Murine Intestine for Antibody Array Analysis by Owens, Joshua A, Jones, Rheinallt M

“…Gut mucosal immune cells play an essential role in health due to their ability to orchestrate host signaling events in response to exogenous antigens. These…”
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