Search Results - "Jones, Peter A."

Functions of DNA methylation: islands, start sites, gene bodies and beyond by Jones, Peter A.

“…Key Points DNA methylation is an epigenetic mark that can be mitotically inherited and is involved in adding stability to the repression of transcription when…”
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Cancer Genetics and Epigenetics: Two Sides of the Same Coin? by You, Jueng Soo, Jones, Peter A.

“…Epigenetic and genetic alterations have long been thought of as two separate mechanisms participating in carcinogenesis. A recent outcome of whole exome…”
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A decade of exploring the cancer epigenome — biological and translational implications by Baylin, Stephen B, Jones, Peter A

“…Epigenetic alterations are leading candidates for the development of specific markers for cancer detection, diagnosis and prognosis, as well as new targets for…”
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Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer by Yang, Xiaojing, Han, Han, De Carvalho, Daniel D., Lay, Fides D., Jones, Peter A., Liang, Gangning

“…DNA methylation in promoters is well known to silence genes and is the presumed therapeutic target of methylation inhibitors. Gene body methylation is…”
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DNA methylation enables transposable element-driven genome expansion by Zhou, Wanding, Liang, Gangning, Molloy, Peter L., Jones, Peter A.

“…Multicellular eukaryotic genomes show enormous differences in size. A substantial part of this variation is due to the presence of transposable elements (TEs)…”
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DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts by Roulois, David, Loo Yau, Helen, Singhania, Rajat, Wang, Yadong, Danesh, Arnavaz, Shen, Shu Yi, Han, Han, Liang, Gangning, Jones, Peter A., Pugh, Trevor J., O’Brien, Catherine, De Carvalho, Daniel D.

“…DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics…”
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DNA methylation: The nuts and bolts of repression by Miranda, Tina Branscombe, Jones, Peter A.

“…DNA methylation is an epigenetic modification which plays an important role in chromatin organization and gene expression. DNA methylation can silence genes…”
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At the tipping point for epigenetic therapies in cancer by Jones, Peter A

“…The field of epigenetics has exploded in the last two decades, with incredible advances in recent years driven by high-throughput sequencing studies. Cancer…”
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Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers by Charlet, Jessica, Duymich, Christopher E., Lay, Fides D., Mundbjerg, Kamilla, Dalsgaard Sørensen, Karina, Liang, Gangning, Jones, Peter A.

“…The role of cytosine methylation in the structure and function of enhancers is not well understood. In this study, we investigate the role of DNA methylation…”
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Efficient activation of hundreds of LTR12C elements reveals cis-regulatory function determined by distinct epigenetic mechanisms by Ohtani, Hitoshi, Liu, Minmin, Liang, Gangning, Jang, H Josh, Jones, Peter A

“…Abstract Long terminal repeats (LTRs), which often contain promoter and enhancer sequences of intact endogenous retroviruses (ERVs), are known to be co-opted…”
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Epigenetic therapy of cancer: past, present and future by Jones, Peter A, Yoo, Christine B

“…The initiation and progression of cancer is controlled by both genetic and epigenetic events. Unlike genetic alterations, which are almost impossible to…”
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Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B by Xu, Ting-Hai, Liu, Minmin, Zhou, X. Edward, Liang, Gangning, Zhao, Gongpu, Xu, H. Eric, Melcher, Karsten, Jones, Peter A.

“…CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated…”
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Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules by Kelly, Theresa K, Liu, Yaping, Lay, Fides D, Liang, Gangning, Berman, Benjamin P, Jones, Peter A

“…DNA methylation and nucleosome positioning work together to generate chromatin structures that regulate gene expression. Nucleosomes are typically mapped using…”
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DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells by Duymich, Christopher E., Charlet, Jessica, Yang, Xiaojing, Jones, Peter A., Liang, Gangning

“…Promoter DNA methylation is a key epigenetic mechanism for stable gene silencing, but is correlated with expression when located in gene bodies. Maintenance…”
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Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine by Liu, Minmin, Ohtani, Hitoshi, Zhou, Wanding, Ørskov, Andreas Due, Charlet, Jessica, Zhang, Yang W., Shen, Hui, Baylin, Stephen B., Liang, Gangning, Grønbæk, Kirsten, Jones, Peter A.

“…Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of…”
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Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells by Liu, Minmin, Thomas, Stacey L, DeWitt, Ashley K, Zhou, Wanding, Madaj, Zachary B, Ohtani, Hitoshi, Baylin, Stephen B, Liang, Gangning, Jones, Peter A

“…Ovarian cancer ranks as the most deadly gynecologic cancer, and there is an urgent need to develop more effective therapies. Previous studies have shown that…”
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DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival by De Carvalho, Daniel D., Sharma, Shikhar, You, Jueng Soo, Su, Sheng-Fang, Taberlay, Phillippa C., Kelly, Theresa K., Yang, Xiaojing, Liang, Gangning, Jones, Peter A.

“…Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant transformation. Whether cancer cells are dependent on these abnormal…”
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Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer by Taberlay, Phillippa C, Statham, Aaron L, Kelly, Theresa K, Clark, Susan J, Jones, Peter A

“…It is well established that cancer-associated epigenetic repression occurs concomitant with CpG island hypermethylation and loss of nucleosomes at promoters,…”
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Vitamin C – A new player in regulation of the cancer epigenome by Gillberg, Linn, Ørskov, Andreas D., Liu, Minmin, Harsløf, Laurine B.S., Jones, Peter A., Grønbæk, Kirsten

“…Over the past few years it has become clear that vitamin C, as a provider of reduced iron, is an essential factor for the function of epigenetic regulators…”
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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation by Miranda, Tina Branscombe, Cortez, Connie C, Yoo, Christine B, Liang, Gangning, Abe, Masanobu, Kelly, Theresa K, Marquez, Victor E, Jones, Peter A

“…DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs…”
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