Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features

Although widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD remain unclear. Lateralization indices were computed for individual thalamic subnuclei of 65 participants (33 healthy controls, 14 amylo...

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Bibliographic Details
Published in:	Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 11; no. 1; pp. 690 - 699
Main Authors:	Low, Audrey, Mak, Elijah, Malpetti, Maura, Chouliaras, Leonidas, Nicastro, Nicolas, Su, Li, Holland, Negin, Rittman, Timothy, Rodríguez, Patricia Vázquez, Passamonti, Luca, Bevan-Jones, W Richard, Jones, PP Simon, Rowe, James B., O'Brien, John T.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2019 Elsevier Wiley
Subjects:	Alzheimer's disease Cognitive aging Magnetic resonance imaging Mild cognitive impairment Neuroimaging Thalamus Thalamus Cognitive aging Magnetic resonance imaging Mild cognitive impairment Alzheimer's disease
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Summary:	Although widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD remain unclear. Lateralization indices were computed for individual thalamic subnuclei of 65 participants (33 healthy controls, 14 amyloid-positive patients with mild cognitive impairment, and 18 patients with AD dementia). We compared lateralization indices across diagnostic groups and correlated them with clinical measures. Although overall asymmetry of the thalamus did not differ between groups, greater leftward lateralization of atrophy in the ventral nuclei was demonstrated in AD, compared with controls and amyloid-positive mild cognitive impairment. Increased posterior ventrolateral and ventromedial nuclei asymmetry were associated with worse cognitive dysfunction, informant-reported neuropsychiatric symptoms, and functional ability. Leftward ventral thalamic atrophy was associated with disease severity in AD. Our findings suggest the clinically relevant involvement of thalamic nuclei in the pathophysiology of AD.
Bibliography:	Joint senior authors. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2352-8729 2352-8729
DOI:	10.1016/j.dadm.2019.08.001