Search Results - "Jones, Owen T"

Targeting of voltage-gated calcium channel α2δ-1 subunit to lipid rafts is independent from a GPI-anchoring motif by Robinson, Philip, Etheridge, Sarah, Song, Lele, Shah, Riddhi, Fitzgerald, Elizabeth M, Jones, Owen T

“…Voltage-gated calcium channels (Ca(v)) exist as heteromultimers comprising a pore-forming α(1) with accessory β and α(2)δ subunits which modify channel…”
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Biosynthesis of the dystonia-associated AAA+ ATPase torsinA at the endoplasmic reticulum by Callan, Anna C, Bunning, Sandra, Jones, Owen T, High, Stephen, Swanton, Eileithyia

“…TorsinA is a widely expressed AAA(+) (ATPases associated with various cellular activities) ATPase of unknown function. Previous studies have described torsinA…”
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Locomotor response to l-DOPA in reserpine-treated rats following central inhibition of aromatic l-amino acid decarboxylase: Further evidence for non-dopaminergic actions of l-DOPA and its metabolites by Alachkar, Amal, Brotchie, Jonathan M., Jones, Owen T.

“…l-DOPA is the most widely used treatment for Parkinson's disease. The anti-parkinsonian and pro-dyskinetic actions of l-DOPA are widely attributed to its…”
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Formation of N-type (Cav 2.2) voltage-gated calcium channel membrane microdomains: Lipid raft association and clustering by Robinson, Philip, Etheridge, Sarah, Song, Lele, Armenise, Paul, Jones, Owen T, Fitzgerald, Elizabeth M

“…Abstract Voltage-gated calcium channels (Cav s) comprise a pore-forming α1 with auxiliary α2 δ and β subunits which modulate Cav function and surface…”
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Identification of an Evolutionarily Conserved Extracellular Threonine Residue Critical for Surface Expression and Its Potential Coupling of Adjacent Voltage-sensing and Gating Domains in Voltage-gated Potassium Channels by Mckeown, Lynn, Burnham, Matthew P., Hodson, Charlotte, Jones, Owen T.

“…The dynamic expression of voltage-gated potassium channels (Kvs) at the cell surface is a fundamental factor controlling membrane excitability. In exploring…”
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Cell Surface Targeting and Clustering Interactions between Heterologously Expressed PSD-95 and the Shal Voltage-gated Potassium Channel, Kv4.2 by Wong, Wei, Newell, Evan W., Jugloff, Denis G.M., Jones, Owen T., Schlichter, Lyanne C.

“…Kv4.2 is a voltage-gated potassium channel that is critical in controlling the excitability of myocytes and neurons. Processes that influence trafficking and…”
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LV-pIN-KDEL: a novel lentiviral vector demonstrates the morphology, dynamics and continuity of the endoplasmic reticulum in live neurones by Jones, Vicky C, McKeown, Lynn, Verkhratsky, Alexei, Jones, Owen T

“…The neuronal endoplasmic reticulum (ER) is an extensive, complex endomembrane system, containing Ca2+ pumps, and Ca2+ channels that permit it to act as a…”
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Molecular basis of inherited calcium channelopathies： role of mutations in pore-forming subunits by McKeown, Lynn, Robinson, Philip, Jones, Owen T

“…The pore-forming alpha subunits of voltage-gated calcium channels contain the essential biophysical machinery that underlies calcium influx in response to cell…”
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PIN-G--a novel reporter for imaging and defining the effects of trafficking signals in membrane proteins by McKeown, Lynn, Robinson, Philip, Greenwood, Sam M, Hu, Weiwen, Jones, Owen T

“…The identification of protein trafficking signals, and their interacting mechanisms, is a fundamental objective of modern biology. Unfortunately, the analysis…”
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Kinetics of internalization and degradation of N-type voltage-gated calcium channels: Role of the α2 /δ subunit by Bernstein, Geula M, Jones, Owen T

“…Abstract The contribution of voltage-gated calcium channels to excitable cell function depends, critically, upon the mechanisms that control their expression…”
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Changes in the mRNA Levels of α2A and α2C Adrenergic Receptors in Rat Models of Parkinson’s Disease and l-DOPA-Induced Dyskinesia by Alachkar, Amal, Brotchie, Jonathan M., Jones, Owen T.

“…The changes in the mRNA levels of α 2A and α 2C adrenoceptors were investigated in unilateral 6-OHDA-lesioned rat model of Parkinson’s disease and l…”
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Impact of Cytoplasmic Calcium Buffering on the Spatial and Temporal Characteristics of Intercellular Calcium Signals in Astrocytes by Wang, Zhong, Tymianski, Michael, Jones, Owen T, Nedergaard, Maiken

“…The impact of calcium buffering on the initiation and propagation of mechanically elicited intercellular Ca2+ waves was studied using astrocytes loaded with…”
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Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors by Alachkar, Amal, Brotchie, Jonathan M, Jones, Owen T

“…The ability of l-3,4-dihydroxyphenylalanine (l-DOPA), l-DOPA-methyl ester and their major metabolites, dopamine, dihydroxyphenylacetic acid (DOPAC),…”
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Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human α2-adrenergic and dopaminergic receptors by Alachkar, Amal, Brotchie, Jonathan M., Jones, Owen T.

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Modulation of High‐Voltage–Activated Calcium Channels in Dentate Granule Cells by Topiramate by Zhang, Xiao‐lei, Velumian, Alexander A., Jones, Owen T., Carlen, Peter L.

“…Purpose: In this study, we assessed the effects of topiramate (TPM) on high‐voltage‐activated calcium channel (HVACC) currents in vitro. Methods: HVACC…”
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The regulation of superoxide production by the NADPH oxidase of neutrophils and other mammalian cells by Jones, O T

“…Superoxide is produced by a NADPH oxidase of phagocytic cells and contributes to their microbicidal activities. The oxidase is activated when receptors in the…”
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Surface expression and distribution of voltage-gated potassium channels in neurons (Review) by McKeown, Lynn, Swanton, Lisa, Robinson, Philip, Jones, Owen T

“…The last decade has witnessed an exponential increase in interest in one of the great mysteries of nerve cell biology: Specifically, how do neurons know where…”
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A lentivirally delivered photoactivatable GFP to assess continuity in the endoplasmic reticulum of neurones and glia by Jones, Vicky C., Rodríguez, José J., Verkhratsky, Alexei, Jones, Owen T.

“…The endoplasmic reticulum (ER) is the largest intracellular membranous organelle. Functions of the ER are many and diverse, which include various biosynthetic,…”
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Development of a pheromone trap monitoring system for orange wheat blossom midge, Sitodiplosis mosellana, in the UK by Bruce, T.J.A, Hooper, A.M, Ireland, L, Jones, O.T, Martin, J.L, Smart, L.E, Oakley, J, Wadhams, L.J

“…Field-trapping experiments with synthetic 2,7-nonadiyl dibutyrate, the female-produced sex pheromone of the orange wheat blossom midge, Sitodiplosis mosellana…”
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PIN-G reporter for imaging and defining trafficking signals in membrane proteins by McKeown, Lynn, Jones, Vicky C, Jones, Owen T

“…The identification of motifs that control the intracellular trafficking of proteins is a fundamental objective of cell biology. Once identified, such regions…”
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