Search Results - "Jones, Owen D."

Is plasticity of synapses the mechanism of long-term memory storage? by Abraham, Wickliffe C., Jones, Owen D., Glanzman, David L.

“…It has been 70 years since Donald Hebb published his formalized theory of synaptic adaptation during learning. Hebb’s seminal work foreshadowed some of the…”
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Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1 by Singh, Anurag, Sateesh, Shruthi, Jones, Owen D., Abraham, Wickliffe C.

“…Long-term potentiation (LTP) is regulated in part by metaplasticity, the activity-dependent alterations in neural state that coordinate the direction,…”
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Mechanisms of heterosynaptic metaplasticity by Hulme, Sarah R., Jones, Owen D., Raymond, Clarke R., Sah, Pankaj, Abraham, Wickliffe C.

“…Synaptic plasticity is fundamental to the neural processes underlying learning and memory. Interestingly, synaptic plasticity itself can be dynamically…”
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The Neural Correlates of Third-Party Punishment by Buckholtz, Joshua W., Asplund, Christopher L., Dux, Paul E., Zald, David H., Gore, John C., Jones, Owen D., Marois, René

“…Legal decision-making in criminal contexts includes two essential functions performed by impartial “third parties:” assessing responsibility and determining an…”
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DETECTING MENS REA IN THE BRAIN by Jones, Owen D., Montague, Read, Yaffe, Gideon

“…Mental states matter. Consequently, we and colleagues designed and executed a brain-imaging experiment attempting to detect - for the first time - differences…”
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Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats by Xiong, Monica, Jones, Owen D, Peppercorn, Katie, Ohline, Shane M, Tate, Warren P, Abraham, Wickliffe C

“…Secreted amyloid precursor protein-α (sAPPα) is a neurotrophic and neuroprotective molecule which can enhance learning and synaptic plasticity. Aging is…”
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Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus by Hulme, Sarah R, Jones, Owen D, Ireland, David R, Abraham, Wickliffe C

“…The Bienenstock, Cooper and Munro (BCM) computational model, which incorporates a metaplastic sliding threshold for LTP induction, accounts well for…”
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Law, responsibility, and the brain by Mobbs, Dean, Lau, Hakwan C, Jones, Owen D, Frith, Christopher D

“…A similar pattern emerges for the amygdala, where damage can result in increased or decreased aggression [23,56]. [...]in court proceedings, many experts have…”
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Sorting guilty minds by Shen, Francis X, Hoffman, Morris B, Jones, Owen D, Greene, Joshua D, Marois, René

“…Because punishable guilt requires that bad thoughts accompany bad acts, the Model Penal Code (MPC) typically requires that jurors infer the mental state of a…”
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Evolution and the expression of biases: situational value changes the endowment effect in chimpanzees by Brosnan, Sarah F, Jones, Owen D, Gardner, Molly, Lambeth, Susan P, Schapiro, Steven J

“…Abstract Cognitive and behavioral biases, which are widespread among humans, have recently been demonstrated in other primates, suggesting a common origin…”
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Emerging roles of metaplasticity in behaviour and disease by Hulme, Sarah R, Jones, Owen D, Abraham, Wickliffe C

“…Highlights • A framework for potential roles of metaplasticity in vivo is presented. • Metaplasticity can prepare synapses and networks for learning. •…”
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Do group I metabotropic glutamate receptors mediate LTD? by Jones, Owen D

“…Synapses undergo significant structural and functional reorganization in response to varying patterns of stimulation. These forms of plasticity are considered…”
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Tumor Necrosis Factor-α-Mediated Metaplastic Inhibition of LTP Is Constitutively Engaged in an Alzheimer's Disease Model by Singh, Anurag, Jones, Owen D, Mockett, Bruce G, Ohline, Shane M, Abraham, Wickliffe C

“…LTP, a fundamental mechanism of learning and memory, is a highly regulated process. One form of regulation is metaplasticity (i.e., the activity-dependent and…”
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Neuroscientists in court by Jones, Owen D., Wagner, Anthony D., Faigman, David L., Raichle, Marcus E.

“…Neuroscientific evidence is increasingly offered in court cases, with neuroscientists often acting as expert witnesses. Jones and colleagues discuss the…”
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Parsing the Behavioral and Brain Mechanisms of Third-Party Punishment by Ginther, Matthew R, Bonnie, Richard J, Hoffman, Morris B, Shen, Francis X, Simons, Kenneth W, Jones, Owen D, Marois, René

“…The evolved capacity for third-party punishment is considered crucial to the emergence and maintenance of elaborate human social organization and is central to…”
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Spatial-temporal rainfall models based on poisson cluster processes by Aryal, Nanda R., Jones, Owen D.

“…We fit stochastic spatial-temporal models to high-resolution rainfall radar data using Approximate Bayesian Computation (ABC). We consider models constructed…”
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Corticolimbic gating of emotion-driven punishment by Treadway, Michael T, Buckholtz, Joshua W, Martin, Justin W, Jan, Katharine, Asplund, Christopher L, Ginther, Matthew R, Jones, Owen D, Marois, René

“…In determining punishment, an actor's mental state often trumps the impact of emotions, as unintended harms may go unpunished, regardless of their magnitude…”
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Law and neuroscience by Jones, Owen D, Marois, René, Farah, Martha J, Greely, Henry T

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Predicting the knowledge–recklessness distinction in the human brain by Vilares, Iris, Wesley, Michael J., Ahn, Woo-Young, Bonnie, Richard J., Hoffman, Morris, Jones, Owen D., Morse, Stephen J., Yaffe, Gideon, Lohrenz, Terry, Montague, P. Read

“…Criminal convictions require proof that a prohibited act was performed in a statutorily specified mental state. Different legal consequences, including greater…”
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Law, evolution and the brain: applications and open questions by Zeki, S., Goodenough, O. R., Jones, Owen D., Jones, Owen D.

“…This paper discusses several issues at the intersection of law and brain science. It focuses principally on ways in which an improved understanding of how…”
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