Search Results - "Jones, Mathew Jk"

Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition by Vora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel AJ, Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew JK, Gabrielli, Brian

“…Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human…”
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SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function by Coleman, Kate E, Békés, Miklós, Chapman, Jessica R, Crist, Sarah B, Jones, Mathew Jk, Ueberheide, Beatrix M, Huang, Tony T

“…NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs)…”
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T cell help controls the speed of the cell cycle in germinal center B cells by Gitlin, Alexander D., Mayer, Christian T., Oliveira, Thiago Y., Shulman, Ziv, Jones, Mathew J. K., Koren, Amnon, Nussenzweig, Michel C.

“…The germinal center (GC) is a microanatomical compartment wherein high-affinity antibody-producing B cells are selectively expanded. B cells proliferate and…”
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Chromothripsis: Chromosomes in Crisis by Jones, Mathew J.K., Jallepalli, Prasad V.

“…During oncogenesis, cells acquire multiple genetic alterations that confer essential tumor-specific traits, including immortalization, escape from…”
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Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response by Grabocka, Elda, Pylayeva-Gupta, Yuliya, Jones, Mathew J.K., Lubkov, Veronica, Yemanaberhan, Eyoel, Taylor, Laura, Jeng, Hao Hsuan, Bar-Sagi, Dafna

“…Mutations in KRAS are prevalent in human cancers and universally predictive of resistance to anticancer therapeutics. Although it is widely accepted that…”
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FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors by Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK, Pagan, Julia K

“…To maintain both mitochondrial quality and quantity, cells selectively remove damaged or excessive mitochondria through mitophagy, which is a specialised form…”
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PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4 by Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M, Pagan, Julia K

“…Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCF FBXL4 ubiquitin ligase complex…”
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Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability by Jones, Mathew JK, Colnaghi, Luca, Huang, Tony T

“…Translesion synthesis polymerases (TLS Pols) are required to tolerate DNA lesions that would otherwise cause replication arrest and cell death. Aberrant…”
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Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing by Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P., Pagano, Michele

“…An intercentrosomal linker keeps a cell’s two centrosomes joined together until it is dissolved at the onset of mitosis. A second connection keeps daughter…”
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Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells by Rahman, Sadia, Jones, Mathew J. K., Jallepalli, Prasad V.

“…The cohesin complex links DNA molecules and plays key roles in the organization, expression, repair, and segregation of eukaryotic genomes. In vertebrates the…”
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Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer by Nazareth, Deborah, Jones, Mathew Jk, Gabrielli, Brian

“…The poor selectivity of standard cytotoxic chemotherapy regimens causes severe side-effects in patients and reduces the quality of life during treatment…”
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The Fanconi anemia pathway in replication stress and DNA crosslink repair by Jones, Mathew J. K., Huang, Tony T.

“…Interstand crosslinks (ICLs) are DNA lesions where the bases of opposing DNA strands are covalently linked, inhibiting critical cellular processes such as…”
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PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4 by Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew Jk, Millard, S Sean, Ng, Dominic Ch, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M, Pagan, Julia K

“…Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCF ubiquitin ligase complex suppresses…”
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Dysregulation of DNA polymerase [kappa] recruitment to replication forks results in genomic instability by Jones, Mathew Jk, Colnaghi, Luca, Huang, Tony T

“…Translesion synthesis polymerases (TLS Pols) are required to tolerate DNA lesions that would otherwise cause replication arrest and cell death. Aberrant…”
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Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability: Polκ recruitment to replication forks results in genomic instability by Jones, Mathew JK, Colnaghi, Luca, Huang, Tony T

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APC/C^sup Cdh1^-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage by Cotto-Rios, Xiomaris M, Jones, Mathew JK, Busino, Luca, Pagano, Michele, Huang, Tony T

“…Targeted protein destruction of critical cellular regulators during the G1 phase of the cell cycle is achieved by anaphase-promoting complex/cyclosome…”
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Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle by Cotto Rios, Xiomaris M., Jones, Mathew J.K., Huang, Tony T.

“…Tight regulation of the cell cycle and DNA repair machinery is essential for maintaining genome stability. The APC/CCdh1 ubiquitin ligase complex is a key…”
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Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair by Colnaghi, Luca, Jones, Mathew J.K., Cotto-Rios, Xiomaris M., Schindler, Detlev, Hanenberg, Helmut, Huang, Tony T.

“…Fanconi anemia (FA) is a rare familial genome instability syndrome caused by mutations in FA genes that results in defective DNA crosslink repair. Activation…”
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A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP by Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B., Khanna, Kum Kum

“…Corepressors play a crucial role in negative gene regulation and are defective in several diseases. BCoR is a corepressor for the BCL6 repressor protein. Here…”
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APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage by Cotto-Rios, Xiomaris M, Jones, Mathew J K, Busino, Luca, Pagano, Michele, Huang, Tony T

“…Targeted protein destruction of critical cellular regulators during the G1 phase of the cell cycle is achieved by anaphase-promoting complex/cyclosome(Cdh1)…”
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