Search Results - "Jones, Justin C"
-
1
Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits
Published in The Journal of neuroscience (02-02-2011)“…Brown adipose tissue (BAT) thermogenesis is critical to maintain homoeothermia and is centrally controlled via sympathetic outputs. Body temperature and BAT…”
Get full text
Journal Article -
2
Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding
Published in Cell metabolism (01-08-2009)“…The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA) and other components of the mesolimbic dopamine (DA) system to…”
Get full text
Journal Article -
3
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells
Published in Brain research (10-03-2011)“…Abstract Leptin acts via the long form of the leptin receptor (LepRb) on specialized sets of neurons in the brain to modulate diverse functions in concert with…”
Get full text
Journal Article -
4
Ventral Tegmental Area Neurotensin Signaling Links the Lateral Hypothalamus to Locomotor Activity and Striatal Dopamine Efflux in Male Mice
Published in Endocrinology (Philadelphia) (01-05-2015)“…Projections from the lateral hypothalamic area (LHA) innervate components of the mesolimbic dopamine (MLDA) system, including the ventral tegmental area (VTA)…”
Get full text
Journal Article -
5
Transcriptional and physiological roles for STAT proteins in leptin action
Published in Molecular metabolism (Germany) (01-04-2019)“…Leptin acts via its receptor LepRb on specialized neurons in the brain to modulate food intake, energy expenditure, and body weight. LepRb activates signal…”
Get full text
Journal Article -
6
IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action
Published in Cell metabolism (02-05-2012)“…Irs2-mediated insulin/IGF1 signaling in the CNS modulates energy balance and glucose homeostasis; however, the site for Irs2 function is unknown. The hormone…”
Get full text
Journal Article -
7
Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance
Published in Molecular metabolism (Germany) (01-08-2018)“…To date, early developmental ablation of leptin receptor (LepRb) expression from circumscribed populations of hypothalamic neurons (e.g., arcuate nucleus (ARC)…”
Get full text
Journal Article -
8
Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status
Published in Endocrinology (Philadelphia) (01-10-2009)“…The medial basal hypothalamus, including the arcuate nucleus (ARC) and the ventromedial hypothalamic nucleus (VMH), integrates signals of energy status to…”
Get full text
Journal Article -
9
Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism
Published in Molecular metabolism (Germany) (01-02-2020)“…Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a…”
Get full text
Journal Article -
10
Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions
Published in Diabetes (New York, N.Y.) (01-04-2010)“…Leptin acts via its receptor (LepRb) to signal the status of body energy stores. Leptin binding to LepRb initiates signaling by activating the associated Janus…”
Get full text
Journal Article -
11
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance
Published in Nature neuroscience (01-12-2014)“…The counter-regulatory response (CRR) restores blood glucose levels after hypoglycemia. The authors identify a population of leptin receptor– and…”
Get full text
Journal Article -
12
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
Published in The Journal of clinical investigation (01-05-2007)“…The adipose-derived hormone, leptin, acts via its receptor (LRb) to convey the status of body energy stores to the brain, decreasing feeding and potentiating…”
Get full text
Journal Article -
13
simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells
Published in Transgenic research (01-10-2007)“…The identification of correctly targeted embryonic stem (ES) cell clones from among the large number of random integrants that result from most selection…”
Get full text
Journal Article -
14
Leptin-inhibited PBN neurons enhance counter-regulatory responses to hypoglycemia in negative energy balance
Published in Nature neuroscience (10-11-2014)“…Hypoglycemia initiates the counter regulatory response (CRR), in which the sympathetic nervous system, glucagon, and glucocorticoids restore glucose to…”
Get full text
Journal Article -
15
Insufficiency of Janus Kinase 2-Autonomous Leptin Preceptor Signals for Most Physiologic Leptin Actions
Published in Diabetes (New York, N.Y.) (2010)Get full text
Journal Article