Search Results - "Jones, Greg"

SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis by Young, Lucy C., Hartig, Nicole, del Río, Isabel Boned, Sari, Sibel, Ringham-Terry, Benjamin, Wainwright, Joshua R., Jones, Greg G., McCormick, Frank, Rodriguez-Viciana, Pablo

“…Dephosphorylation of the inhibitory “S259” site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a key role in RAF activation. The MRAS GTPase, a close…”
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The opioid epidemic in the United States—Overview, origins, and potential solutions by Jones, Greg H., Bruera, Eduardo, Abdi, Salahadin, Kantarjian, Hagop M.

“…The opioid epidemic in the United States has reached a crisis level. Opioid overdose caused about 65,000 deaths in the United States in 2016…”
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The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding by Beggs, James E, Tian, Shuye, Jones, Greg G, Xie, Jianling, Iadevaia, Valentina, Jenei, Veronika, Thomas, Gareth, Proud, Christopher G

“…The MAP kinase-interacting kinases (Mnk1 and Mnk2) are activated by ERK and are best known for phosphorylating the translation initiation factor eIF4E. Genetic…”
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The many roads to universal health care in the USA by Jones, Greg, BS, Kantarjian, Hagop, MD

“…SummaryHealth-care systems in different countries have evolved along different paths, with some countries offering private insurance, some universal health…”
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Targeted sequencing of plasma cell-free DNA to predict response to PD1 inhibitors in advanced non-small cell lung cancer by Guibert, Nicolas, Jones, Greg, Beeler, John F., Plagnol, Vincent, Morris, Clive, Mourlanette, Jean, Delaunay, Myriam, Keller, Laura, Rouquette, Isabelle, Favre, Gilles, Pradines, Anne, Mazieres, Julien

“…•Targeted (36 genes) plasma NGS was performed in 86 patients treated with ICI.•Combination of molecular determinants of response to ICI can predict…”
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SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers by Jones, Greg G., del Río, Isabel Boned, Sari, Sibel, Sekerim, Aysen, Young, Lucy C., Hartig, Nicole, Areso Zubiaur, Itziar, El-Bahrawy, Mona A., Hynds, Rob E., Lei, Winnie, Molina-Arcas, Miriam, Downward, Julian, Rodriguez-Viciana, Pablo

“…Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The…”
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SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics by del Río, Isabel Boned, Young, Lucy C., Sari, Sibel, Jones, Greg G., Ringham-Terry, Benjamin, Hartig, Nicole, Rejnowicz, Ewa, Lei, Winnie, Bhamra, Amandeep, Surinova, Silvia, Rodriguez-Viciana, Pablo

“…Despite the crucial role of RAF kinases in cell signaling and disease, we still lack a complete understanding of their regulation. Heterodimerization of RAF…”
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Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA by Gale, Davina, Lawson, Andrew R J, Howarth, Karen, Madi, Mikidache, Durham, Bradley, Smalley, Sarah, Calaway, John, Blais, Shannon, Jones, Greg, Clark, James, Dimitrov, Peter, Pugh, Michelle, Woodhouse, Samuel, Epstein, Michael, Fernandez-Gonzalez, Ana, Whale, Alexandra S, Huggett, Jim F, Foy, Carole A, Jones, Gerwyn M, Raveh-Amit, Hadas, Schmitt, Karin, Devonshire, Alison, Green, Emma, Forshew, Tim, Plagnol, Vincent, Rosenfeld, Nitzan

“…Detection and monitoring of circulating tumor DNA (ctDNA) is rapidly becoming a diagnostic, prognostic and predictive tool in cancer patient care. A growing…”
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Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling by Plagnol, Vincent, Woodhouse, Samuel, Howarth, Karen, Lensing, Stefanie, Smith, Matt, Epstein, Michael, Madi, Mikidache, Smalley, Sarah, Leroy, Catherine, Hinton, Jonathan, de Kievit, Frank, Musgrave-Brown, Esther, Herd, Colin, Baker-Neblett, Katherine, Brennan, Will, Dimitrov, Peter, Campbell, Nathan, Morris, Clive, Rosenfeld, Nitzan, Clark, James, Gale, Davina, Platt, Jamie, Calaway, John, Jones, Greg, Forshew, Tim

“…Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to…”
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Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC) by Ricciuti, Biagio, Jones, Greg, Severgnini, Mariano, Alessi, Joao V, Recondo, Gonzalo, Lawrence, Marissa, Forshew, Tim, Lydon, Christine, Nishino, Mizuki, Cheng, Michael, Awad, Mark

“…BackgroundCurrently available biomarkers are imperfect in their ability to predict responses to the multiple first-line treatment options available for…”
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Unlocking the UK Continental Shelf Electrification Potential for Offshore Oil and Gas Installations: A Power Grid Architecture Perspective by Elgenedy, Mohamed, Ahmed, Khaled, Burt, Graeme, Rogerson, Graeme, Jones, Greg

“…Most of the UK Continental Shelf (UKCS) oil and gas (OG) installations have traditionally adopted in situ power generation, which is not only inefficient but…”
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Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway by Munasinghe, Pujika Emani, Riu, Federica, Dixit, Parul, Edamatsu, Midori, Saxena, Pankaj, Hamer, Nathan S.J, Galvin, Ivor F, Bunton, Richard W, Lequeux, Sharon, Jones, Greg, Lamberts, Regis R, Emanueli, Costanza, Madeddu, Paolo, Katare, Rajesh

“…Abstract Background Diabetes promotes progressive loss of cardiac cells, which are replaced by a fibrotic matrix, resulting in the loss of cardiac function. In…”
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Evolution of Transmembrane Protein Kinases Implicated in Coordinating Remodeling of Gram-Positive Peptidoglycan: Inside versus Outside by JONES, Greg, DYSON, Paul

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Opioid Epidemic in the United States—Overview, Origins, and Potential Solutions by Jones, Greg H, Bruera, Eduardo, Abdi, Salahadin, Kantarjian, Hagop M

“…(Abstracted from Cancer 2018;124:4279–4286)Over the last 20 years, there has been a staggering increase in addiction to opiates and the number of deaths from…”
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Virtual histology of transgenic mouse embryos for high-throughput phenotyping by Johnson, John T, Hansen, Mark S, Wu, Isabel, Healy, Lindsey J, Johnson, Christopher R, Jones, Greg M, Capecchi, Mario R, Keller, Charles

“…A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse…”
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Roadblocks to Low Temperature District Heating by Millar, Michael-Allan, Elrick, Bruce, Jones, Greg, Yu, Zhibin, Burnside, Neil M.

“…Energy usage in buildings is coming increasingly under the spotlight as carbon policy focus shifts towards the utilization of thermal energy. In the UK,…”
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Board Gender Diversity and CSR Reporting: Evidence from Jordan by Al Fadli, Amer, Sands, John, Jones, Greg, Beattie, Claire, Pensiero, Dom

“…This study investigates whether board gender diversity influences corporate social responsibility (CSR) reporting in Jordan, where there are no gender board…”
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Adjuvant nivolumab, capecitabine or the combination in patients with residual triple-negative breast cancer: the OXEL randomized phase II study by Lynce, Filipa, Mainor, Candace, Donahue, Renee N., Geng, Xue, Jones, Greg, Schlam, Ilana, Wang, Hongkun, Toney, Nicole J., Jochems, Caroline, Schlom, Jeffrey, Zeck, Jay, Gallagher, Christopher, Nanda, Rita, Graham, Deena, Stringer-Reasor, Erica M., Denduluri, Neelima, Collins, Julie, Chitalia, Ami, Tiwari, Shruti, Nunes, Raquel, Kaltman, Rebecca, Khoury, Katia, Gatti-Mays, Margaret, Tarantino, Paolo, Tolaney, Sara M., Swain, Sandra M., Pohlmann, Paula, Parsons, Heather A., Isaacs, Claudine

“…Chemotherapy and immune checkpoint inhibitors have a role in the post-neoadjuvant setting in patients with triple-negative breast cancer (TNBC). However, the…”
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Outcomes in oncogenic-addicted advanced NSCLC patients with actionable mutations identified by liquid biopsy genomic profiling using a tagged amplicon-based NGS assay by Remon, Jordi, Swalduz, Aurelie, Planchard, David, Ortiz-Cuaran, Sandra, Mezquita, Laura, Lacroix, Ludovic, Jovelet, Cecile, Rouleau, Etienne, Leonce, Camille, De Kievit, Frank, Morris, Clive, Jones, Greg, Mercier, Kelly, Howarth, Karen, Green, Emma, Pérol, Maurice, Saintigny, Pierre, Besse, Benjamin

“…Circulating tumor DNA (ctDNA)-based molecular profiling is rapidly gaining traction in clinical practice of advanced cancer patients with multi-gene…”
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Author Correction: Adjuvant nivolumab, capecitabine or the combination in patients with residual triple-negative breast cancer: the OXEL randomized phase II study by Lynce, Filipa, Mainor, Candace, Donahue, Renee N., Geng, Xue, Jones, Greg, Schlam, Ilana, Wang, Hongkun, Toney, Nicole J., Jochems, Caroline, Schlom, Jeffrey, Zeck, Jay, Gallagher, Christopher, Nanda, Rita, Graham, Deena, Stringer-Reasor, Erica M., Denduluri, Neelima, Collins, Julie, Chitalia, Ami, Tiwari, Shruti, Nunes, Raquel, Kaltman, Rebecca, Khoury, Katia, Gatti-Mays, Margaret, Tarantino, Paolo, Tolaney, Sara M., Swain, Sandra M., Pohlmann, Paula, Parsons, Heather A., Isaacs, Claudine

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