Search Results - "Jones, Gavin C."

  • Showing 1 - 18 results of 18
Refine Results
  1. 1
  2. 2
  3. 3

    The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells by Corps, Anthony N., Jones, Gavin C., Harrall, Rebecca L., Curry, Valerie A., Hazleman, Brian L., Riley, Graham P.

    Published in Matrix biology (01-06-2008)
    “…Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates…”
    Get full text
    Journal Article
  4. 4

    Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβ by Jones, Eleanor R., Jones, Gavin C., Legerlotz, Kirsten, Riley, Graham P.

    Published in Biochimica et biophysica acta (01-12-2013)
    “…Tendinopathies are a range of diseases characterised by degeneration and chronic tendon pain and represent a significant cause of morbidity. Relatively little…”
    Get full text
    Journal Article
  5. 5
  6. 6

    ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis by Jones, Gavin C, Riley, Graham P

    Published in Arthritis research & therapy (01-01-2005)
    “…Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and…”
    Get full text
    Journal Article
  7. 7
  8. 8

    Selective inhibition of ADAMTS‐1, ‐4 and ‐5 by catechin gallate esters by Vankemmelbeke, Mireille N., Jones, Gavin C., Fowles, Cyprianne, Ilic, Mirna Z., Handley, Christopher J., Day, Anthony J., Knight, C. Graham, Mort, John S., Buttle, David J.

    Published in European journal of biochemistry (01-06-2003)
    “…Three mammalian ADAMTS enzymes, ADAMTS‐1, ‐4 and ‐5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for…”
    Get full text
    Journal Article
  9. 9

    The effect of sulfide concentrate mineralogy and texture on Reactive Oxygen Species (ROS) generation by Jones, Gavin C., Becker, Megan, van Hille, Robert P., Harrison, Susan T.L.

    Published in Applied geochemistry (01-02-2013)
    “…► Metal-containing sulfide mineral concentrates generate ROS (H2O2+OH). ► ROS generation linked to decreased thermophilic bioleaching performance. ► ROS…”
    Get full text
    Journal Article
  10. 10

    A novel microwell-based analytical technique for studying ferrous iron biooxidation activity by Meissner, Murray P., Xu, Zhehua, Jones, Gavin C., Minnaar, Susanna H., Harrison, Susan T.L.

    Published in Minerals engineering (01-06-2014)
    “…•Fe oxidation activity of a mixed bioleaching culture was monitored in a microwell plate apparatus.•Comparable growth and iron oxidation trends to shake flasks…”
    Get full text
    Journal Article
  11. 11

    Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon by Jones, Gavin C., Corps, Anthony N., Pennington, Caroline J., Clark, Ian M., Edwards, Dylan R., Bradley, Michelle M., Hazleman, Brian L., Riley, Graham P.

    Published in Arthritis and rheumatism (01-03-2006)
    “…Objective To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue…”
    Get full text
    Journal Article
  12. 12

    The role of proteases in pathologies of the synovial joint by Jones, Gavin C., Riley, Graham P., Buttle, David J.

    “…Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost…”
    Get full text
    Journal Article
  13. 13

    Expression of recombinant ADAMTS in insect cells by Jones, Gavin C, Vankemmelbeke, Mireille N, Buttle, David J

    “…The "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) enzymes are secreted proteinases involved in development, blood clotting and the…”
    Get more information
    Journal Article
  14. 14

    A method for the non-covalent immobilization of heparin to surfaces by Mahoney, David J, Whittle, Jason D, Milner, Caroline M, Clark, Simon J, Mulloy, Barbara, Buttle, David J, Jones, Gavin C, Day, Anthony J, Short, Robert D

    Published in Analytical biochemistry (01-07-2004)
    “…The interaction of heparan sulfate (HS) with specific proteins facilitates a wide range of fundamental biological processes including cellular proliferation…”
    Get full text
    Journal Article
  15. 15

    ADAMTS proteinases: potential therapeutic targets? by Jones, Gavin C

    Published in Current pharmaceutical biotechnology (01-02-2006)
    “…ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases have been implicated in a number of connective tissue pathologies including…”
    Get more information
    Journal Article
  16. 16

    ADAMTS-4 activity on a proteoglycan vs. a polypeptide is controlled by the ancillary domains by Jones, Gavin C., Vankemmelbeke, Mireille N., Verheijen, Jan H., DeDood, Claudia, Day, Anthony J., Buttle, David J.

    “…Introduction  In combination with the catalytic domain, the ancillary domains of the ADAMTS' are proposed to regulate activity via interactions with sulfated…”
    Get full text
    Journal Article
  17. 17
  18. 18

    The generation of toxic reactive oxygen species (ROS) from mechanically activated sulphide concentrates and its effect on thermophilic bioleaching by Jones, Gavin C., Corin, Kirsten C., van Hille, Robert P., Harrison, Susan T.L.

    Published in Minerals engineering (01-09-2011)
    “…► A planetary and vibratory mill was used to mechanically activate pyrite and chalcopyrite. ► XRD line profile analysis showed that planetary milled samples…”
    Get full text
    Journal Article