Search Results - "Jones, Gareth W."

Ectopic lymphoid-like structures in infection, cancer and autoimmunity by Pitzalis, Costantino, Jones, Gareth W., Bombardieri, Michele, Jones, Simon A.

“…Key Points Ectopic lymphoid-like structure neogenesis is a common clinical occurrence and contributes to the pathology that is associated with cancer,…”
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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation by Jones, Nicholas, Blagih, Julianna, Zani, Fabio, Rees, April, Hill, David G., Jenkins, Benjamin J., Bull, Caroline J., Moreira, Diana, Bantan, Azari I. M., Cronin, James G., Avancini, Daniele, Jones, Gareth W., Finlay, David K., Vousden, Karen H., Vincent, Emma E., Thornton, Catherine A.

“…Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver…”
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Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis by Jones, Gareth W, Bombardieri, Michele, Greenhill, Claire J, McLeod, Louise, Nerviani, Alessandra, Rocher-Ros, Vidalba, Cardus, Anna, Williams, Anwen S, Pitzalis, Costantino, Jenkins, Brendan J, Jones, Simon A

“…Ectopic lymphoid-like structures (ELSs) reminiscent of secondary lymphoid organs often develop at sites of chronic inflammation where they contribute to…”
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The biology behind interleukin-6 targeted interventions by Liu, Xiao, Jones, Gareth W, Choy, Ernest H, Jones, Simon A

“…PURPOSE OF REVIEWBiological drugs that target the inflammatory cytokine interleukin-6 (IL-6) are increasingly considered as therapies for chronic disease and…”
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Hyperactive gp130/STAT3‐driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development by Hill, David G., Yu, Liang, Gao, Hugh, Balic, Jesse J., West, Alison, Oshima, Hiroko, McLeod, Louise, Oshima, Masanobu, Gallimore, Awen, D'Costa, Kimberley, Bhathal, Prithi S., Sievert, William, Ferrero, Richard L., Jenkins, Brendan J., Jones, Gareth W.

“…Tertiary lymphoid structures (TLSs) display phenotypic and functional characteristics of secondary lymphoid organs, and often develop in tissues affected by…”
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Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor by Garbers, Christoph, Thaiss, Wolfgang, Jones, Gareth W., Waetzig, Georg H., Lorenzen, Inken, Guilhot, Florence, Lissilaa, Rami, Ferlin, Walter G., Grötzinger, Joachim, Jones, Simon A., Rose-John, Stefan, Scheller, Jürgen

“…IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically…”
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Designing electronic properties of two-dimensional crystals through optimization of deformations by Jones, Gareth W, Pereira, Vitor M

“…One of the enticing features common to most of the two-dimensional (2D) electronic systems that, in the wake of (and in parallel with) graphene, are currently…”
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Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence by Clement, Mathew, Marsden, Morgan, Stacey, Maria A, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana, Scurr, Martin J, Ghazal, Peter, Weaver, Casey T, Carlesso, Gianluca, Clare, Simon, Jones, Simon A, Godkin, Andrew, Jones, Gareth W, Humphreys, Ian R

“…CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts…”
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Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis by Nowell, Mari A, Williams, Anwen S, Carty, Sarah A, Scheller, Jurgen, Hayes, Anthony J, Jones, Gareth W, Richards, Peter J, Slinn, Simon, Ernst, Matthias, Jenkins, Brendan J, Topley, Nicholas, Rose-John, Stefan, Jones, Simon A

“…Cytokine control of the synovial infiltrate is a central process in the development of inflammatory arthritis. In this study, we combine genetic approaches and…”
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Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction by Greenhill, Claire J, Jones, Gareth W, Nowell, Mari A, Newton, Zarabeth, Harvey, Ann K, Moideen, Abdul N, Collins, Fraser L, Bloom, Anja C, Coll, Rebecca C, Robertson, Avril A B, Cooper, Matthew A, Rosas, Marcela, Taylor, Philip R, O'Neill, Luke A, Humphreys, Ian R, Williams, Anwen S, Jones, Simon A

“…Activation of the inflammasome has been implicated in the pathology of various autoinflammatory and autoimmune diseases. While the NLRP3 inflammasome has been…”
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Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation by Fielding, Ceri A., Jones, Gareth W., McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S., Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D., Williams, Geraint T., Davies, Simon J., Humphreys, Ian R., O’Donnell, Valerie B., Taylor, Philip R., Jenkins, Brendan J., Topley, Nicholas, Jones, Simon A.

“…Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark of many chronic degenerative diseases. By using a model of acute…”
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Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells by Longhi, Maria Paula, Wright, Kate, Lauder, Sarah N, Nowell, Mari A, Jones, Gareth W, Godkin, Andrew J, Jones, Simon A, Gallimore, Awen M

“…Currently, our understanding of mechanisms underlying cell-mediated immunity and particularly of mechanisms that promote robust T cell memory to respiratory…”
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Ectopic lymphoid follicles: inducible centres for generating antigen‐specific immune responses within tissues by Jones, Gareth W., Jones, Simon A.

“…Summary Lymphoid neogenesis is traditionally viewed as a pre‐programmed process that promotes the formation of lymphoid organs during development. Here, the…”
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The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17 by Kennedy, Catherine L, Najdovska, Meri, Jones, Gareth W, McLeod, Louise, Hughes, Norman R, Allison, Cody, Huey Ooi, Chia, Tan, Patrick, Ferrero, Richard L, Jones, Simon A, Dev, Anouk, Sievert, William, Bhathal, Prithi S, Jenkins, Brendan J

“…Chronic activation of the gastric mucosal adaptive immune response is a characteristic trait of gastric cancer. It has recently emerged that a new class of T…”
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Cry48Aa-Cry49Aa binary toxin from Bacillus sphaericus exhibits highly restricted target specificity by Jones, Gareth W, Wirth, Margaret C, Monnerat, Rose G, Berry, Colin

“…The Cry48Aa/Cry49Aa binary toxin of Bacillus sphaericus was recently discovered by its ability to kill Culex quinquefasciatus mosquito larvae through a novel…”
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Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together by Jones, Gareth W, Hill, David G, Jones, Simon A

“…Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer, and…”
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LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells by Orr, Selinda J, Burg, Ashley R, Chan, Tim, Quigley, Laura, Jones, Gareth W, Ford, Jill W, Hodge, Deborah, Razzook, Catherine, Sarhan, Joseph, Jones, Yava L, Whittaker, Gillian C, Boelte, Kimberly C, Lyakh, Lyudmila, Cardone, Marco, O'Connor, Geraldine M, Tan, Cuiyan, Li, Hongchuan, Anderson, Stephen K, Jones, Simon A, Zhang, Weiguo, Taylor, Philip R, Trinchieri, Giorgio, McVicar, Daniel W

“…Fungal pathogens elicit cytokine responses downstream of immunoreceptor tyrosine-based activation motif (ITAM)-coupled or hemiITAM-containing receptors and…”
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Quantized Transport, Strain-Induced Perfectly Conducting Modes, and Valley Filtering on Shape-Optimized Graphene Corbino Devices by Jones, Gareth W, Bahamon, Dario Andres, Castro Neto, Antonio H, Pereira, Vitor M

“…The extreme mechanical resilience of graphene and the peculiar coupling it hosts between lattice and electronic degrees of freedom have spawned a strong…”
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Emerging roles for IL-6 family cytokines as positive and negative regulators of ectopic lymphoid structures by Hill, David G., Ward, Amy, Nicholson, Lindsay B., Jones, Gareth W.

“…•Ectopic lymphoid structures (ELS) are a hallmark of chronic tissue inflammation.•ELS are inducible sites that promote autoimmune and anti-tumour immune…”
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Tracking Cardiovascular Comorbidity in Models of Chronic Inflammatory Disease by Morrin, Aisling S, Eastham, Simon, Williams, Anwen S, Jones, Gareth W

“…Immune-mediated inflammatory diseases (IMIDs) are commonly associated with complex coexisting conditions, and cardiovascular comorbidities are a common cause…”
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