Search Results - "Jones, G. Mark"

Idiopathic pulmonary fibrosis by Richeldi, Luca, Prof, Collard, Harold R, MD, Jones, Mark G, PhD

“…Summary Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease. Healthy tissue is replaced by altered extracellular…”
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Idiopathic pulmonary fibrosis: Disease mechanisms and drug development by Spagnolo, Paolo, Kropski, Jonathan A., Jones, Mark G., Lee, Joyce S., Rossi, Giulio, Karampitsakos, Theodoros, Maher, Toby M., Tzouvelekis, Argyrios, Ryerson, Christopher J.

“…Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause characterized by relentless scarring of the lung parenchyma leading to…”
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X-ray Micro-Computed Tomography for Nondestructive Three-Dimensional (3D) X-ray Histology by Katsamenis, Orestis L., Olding, Michael, Warner, Jane A., Chatelet, David S., Jones, Mark G., Sgalla, Giacomo, Smit, Bennie, Larkin, Oliver J., Haig, Ian, Richeldi, Luca, Sinclair, Ian, Lackie, Peter M., Schneider, Philipp

“…Historically, micro-computed tomography (μCT) has been considered unsuitable for histologic analysis of unstained formalin-fixed, paraffin-embedded soft tissue…”
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Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis by Hill, Charlotte, Li, Juanjuan, Liu, Dian, Conforti, Franco, Brereton, Christopher J., Yao, Liudi, Zhou, Yilu, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Ottensmeier, Christian H., Steele, Andrew J., Downward, Julian, Richeldi, Luca, Lu, Xin, Davies, Donna E., Jones, Mark G., Wang, Yihua

“…Idiopathic pulmonary fibrosis (IPF), the prototypic progressive fibrotic interstitial lung disease, is thought to be a consequence of repetitive micro-injuries…”
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Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis by Jones, Mark G, Andriotis, Orestis G, Roberts, James Jw, Lunn, Kerry, Tear, Victoria J, Cao, Lucy, Ask, Kjetil, Smart, David E, Bonfanti, Alessandra, Johnson, Peter, Alzetani, Aiman, Conforti, Franco, Doherty, Regan, Lai, Chester Y, Johnson, Benjamin, Bourdakos, Konstantinos N, Fletcher, Sophie V, Marshall, Ben G, Jogai, Sanjay, Brereton, Christopher J, Chee, Serena J, Ottensmeier, Christian H, Sime, Patricia, Gauldie, Jack, Kolb, Martin, Mahajan, Sumeet, Fabre, Aurelie, Bhaskar, Atul, Jarolimek, Wolfgang, Richeldi, Luca, O'Reilly, Katherine Ma, Monk, Phillip D, Thurner, Philipp J, Davies, Donna E

“…Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in…”
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Contemporary Concise Review 2018: Interstitial lung disease by Mari, Pier‐Valerio, G. Jones, Mark, Richeldi, Luca

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"Velcro-type" crackles predict specific radiologic features of fibrotic interstitial lung disease by Sgalla, Giacomo, Walsh, Simon L F, Sverzellati, Nicola, Fletcher, Sophie, Cerri, Stefania, Dimitrov, Borislav, Nikolic, Dragana, Barney, Anna, Pancaldi, Fabrizio, Larcher, Luca, Luppi, Fabrizio, Jones, Mark G, Davies, Donna, Richeldi, Luca

“…"Velcro-type" crackles on chest auscultation are considered a typical acoustic finding of Fibrotic Interstitial Lung Disease (FILD), however whether they may…”
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Predicting the risk of chest radiograph abnormality 12-weeks post hospitalisation with SARS CoV-2 PCR confirmed COVID-19 by Wallis, Tim JM, Welham, Benjamin, Kong, Alex, Morelli, Tommaso, Azim, Adnan, Horno, Jose, Wilkinson, Miranda, Burke, Hannah, Freeman, Anna, Wilkinson, Thomas MA, Jones, Mark G, Marshall, Benjamin G

“…Background Routine follow-up of patients hospitalised with COVID-19 is recommended, however due to the ongoing high number of infections this is not without…”
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Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by Brereton, Christopher J, Yao, Liudi, Davies, Elizabeth R, Zhou, Yilu, Vukmirovic, Milica, Bell, Joseph A, Wang, Siyuan, Ridley, Robert A, Dean, Lareb S N, Andriotis, Orestis G, Conforti, Franco, Brewitz, Lennart, Mohammed, Soran, Wallis, Timothy, Tavassoli, Ali, Ewing, Rob M, Alzetani, Aiman, Marshall, Benjamin G, Fletcher, Sophie V, Thurner, Philipp J, Fabre, Aurelie, Kaminski, Naftali, Richeldi, Luca, Bhaskar, Atul, Schofield, Christopher J, Loxham, Matthew, Davies, Donna E, Wang, Yihua, Jones, Mark G

“…Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that…”
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Deconvolution of RNA-Seq Analysis of Hyperbaric Oxygen-Treated Mice Lungs Reveals Mesenchymal Cell Subtype Changes by Yuan, Yuan, Zhou, Yilu, Li, Yali, Hill, Charlotte, Ewing, Rob M, Jones, Mark G, Davies, Donna E, Jiang, Zhenglin, Wang, Yihua

“…Hyperbaric oxygen (HBO) is widely applied to treat several hypoxia-related diseases. Previous studies have focused on the immediate effect of HBO-exposure…”
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Opportunities to diagnose fibrotic lung diseases in routine care: A primary care cohort study by Jones, Mark G., Hillyar, Christopher R.T., Nibber, Anjan, Chisholm, Alison, Wilson, Andrew, Maher, Toby M., Kaplan, Alan, Price, David, Walsh, Simon, Richeldi, Luca

“…ABSTRACT Background and objective Temporal trends of healthcare use in the period before a diagnosis of pulmonary fibrosis are poorly understood. We…”
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Sarcoidosis versus Granulomatous and Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency: A Comparative Review by Buso, Helena, Discardi, Claudia, Bez, Patrick, Muscianisi, Francesco, Ceccato, Jessica, Milito, Cinzia, Firinu, Davide, Landini, Nicholas, Jones, Mark G, Felice, Carla, Rattazzi, Marcello, Scarpa, Riccardo, Cinetto, Francesco

“…Sarcoidosis and Granulomatous and Lymphocytic Interstitial Lung Diseases (GLILD) are two rare entities primarily characterised by the development of…”
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LKB1 depletion-mediated epithelial–mesenchymal transition induces fibroblast activation in lung fibrosis by Xu, Zijian, Davies, Elizabeth R., Yao, Liudi, Zhou, Yilu, Li, Juanjuan, Alzetani, Aiman, Marshall, Ben G., Hancock, David, Wallis, Tim, Downward, Julian, Ewing, Rob M., Davies, Donna E., Jones, Mark G., Wang, Yihua

“…The factors that determine fibrosis progression or normal tissue repair are largely unknown. We previously demonstrated that autophagy inhibition-mediated…”
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Idiopathic pulmonary fibrosis: recent trials and current drug therapy by Jones, Mark G, Fletcher, Sophie, Richeldi, Luca

“…Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease with increasing incidence; the median survival is only 35 months and as yet no therapy…”
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The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis by Conforti, Franco, Davies, Elizabeth R, Calderwood, Claire J, Thatcher, Thomas H, Jones, Mark G, Smart, David E, Mahajan, Sumeet, Alzetani, Aiman, Havelock, Tom, Maher, Toby M, Molyneaux, Philip L, Thorley, Andrew J, Tetley, Teresa D, Warner, Jane A, Packham, Graham, Ganesan, A, Skipp, Paul J, Marshall, Benjamin J, Richeldi, Luca, Sime, Patricia J, O'Reilly, Katherine M A, Davies, Donna E

“…Idiopathic pulmonary fibrosis (IPF) is a progressive disease that usually affects elderly people. It has a poor prognosis and there are limited therapies…”
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Idiopathic pulmonary fibrosis: securing a confident diagnosis for every patient by Jones, Mark G, Walsh, Simon L F, Jones, Kirk D, Richeldi, Luca

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Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2 by Bell, Joseph A., Davies, Elizabeth R., Brereton, Christopher J., Vukmirovic, Milica, Roberts, James J.W., Lunn, Kerry, Wickens, Leanne, Conforti, Franco, Ridley, Robert A., Ceccato, Jessica, Sayer, Lucy N., Johnston, David A., Vallejo, Andres F., Alzetani, Aiman, Jogai, Sanjay, Marshall, Ben G., Fabre, Aurelie, Richeldi, Luca, Monk, Phillip D., Skipp, Paul, Kaminski, Naftali, Offer, Emily, Wang, Yihua, Davies, Donna E., Jones, Mark G.

“…Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis…”
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Individualised Exercise Training Enhances Antioxidant Buffering Capacity in Idiopathic Pulmonary Fibrosis by Wallis, Tim J. M., Minnion, Magdalena, Freeman, Anna, Bates, Andrew, Otto, James M., Wootton, Stephen A., Fletcher, Sophie V., Grocott, Michael P. W., Feelisch, Martin, Jones, Mark G., Jack, Sandy

“…Exercise training is recommended for patients with idiopathic pulmonary fibrosis (IPF); however, the mechanism(s) underlying its physiological benefits remain…”
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Time taken from primary care referral to a specialist centre diagnosis of idiopathic pulmonary fibrosis: an opportunity to improve patient outcomes? by Brereton, Christopher J., Wallis, Timothy, Casey, Michelle, Fox, Lynn, Pontopiddan, Katarina, Laws, Diane, Graves, Jennifer, Titmuss, Vanessa, Kearney, Sarah, Evans, Sian, Grove, Alison, Hamid, Samreen, Richeldi, Luca, O'Reilly, Katherine M.A., Fletcher, Sophie V., Jones, Mark G.

“…The care of patients with idiopathic pulmonary fibrosis (IPF) has been transformed by the widespread approval of antifibrotic therapies [1]. Within primary…”
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Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial-Mesenchymal Transition by Zhou, Yilu, Hill, Charlotte, Yao, Liudi, Li, Juanjuan, Hancock, David, Downward, Julian, Jones, Mark G, Davies, Donna E, Ewing, Rob M, Skipp, Paul, Wang, Yihua

“…Alveolar type II (ATII) epithelial cells function as stem cells, contributing to alveolar renewal, repair and cancer. Therefore, they are a highly relevant…”
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