Search Results - "Jones, Eric M"

Structural and functional characterization of G protein-coupled receptors with deep mutational scanning by Jones, Eric M, Lubock, Nathan B, Venkatakrishnan, A J, Wang, Jeffrey, Tseng, Alex M, Paggi, Joseph M, Latorraca, Naomi R, Cancilla, Daniel, Satyadi, Megan, Davis, Jessica E, Babu, M Madan, Dror, Ron O, Kosuri, Sriram

“…The >800 human G protein-coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of…”
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Fibril Conformation as the Basis of Species- and Strain-Dependent Seeding Specificity of Mammalian Prion Amyloids by Jones, Eric M., Surewicz, Witold K.

“…Spongiform encephalopathies are believed to be transmitted by self-perpetuating conformational conversion of the prion protein. It was shown recently that…”
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Electrostatic Interactions at N- and C‑Termini Determine Fibril Polymorphism in Serum Amyloid A Fragments by Jannone, Justine M, Grigg, James I, Aguirre, Lauren M, Jones, Eric M

“…Amyloid polymorphism presents a challenge to physical theories of amyloid formation and stability. The amyloidogenic protein serum amyloid A (SAA) exhibits…”
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Differential Control of Heme Reactivity in Alpha and Beta Subunits of Hemoglobin: A Combined Raman Spectroscopic and Computational Study by Jones, Eric M, Monza, Emanuele, Balakrishnan, Gurusamy, Blouin, George C, Mak, Piotr J, Zhu, Qianhong, Kincaid, James R, Guallar, Victor, Spiro, Thomas G

“…The use of hybrid hemoglobin (Hb), with mesoheme substituted for protoheme, allows separate monitoring of the α or β hemes along the allosteric pathway. Using…”
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Heme Reactivity is Uncoupled from Quaternary Structure in Gel-Encapsulated Hemoglobin: A Resonance Raman Spectroscopic Study by Jones, Eric M, Balakrishnan, Gurusamy, Spiro, Thomas G

“…Encapsulation of hemoglobin (Hb) in silica gel preserves structure and function but greatly slows protein motion, thereby providing access to intermediates…”
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Combination screen in multi-cell type tumor spheroids reveals interaction between aryl hydrocarbon receptor antagonists and E1 ubiquitin-activating enzyme inhibitor by Dexheimer, Thomas S., Coussens, Nathan P., Silvers, Thomas, Jones, Eric M., Chen, Li, Fang, Jianwen, Morris, Joel, Moscow, Jeffrey A., Doroshow, James H., Teicher, Beverly A.

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates genes of drug transporters and metabolic enzymes to detoxify…”
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The Emerging Principles of Mammalian Prion Propagation and Transmissibility Barriers:  Insight from Studies in Vitro by Surewicz, Witold K, Jones, Eric M, Apetri, Adrian C

“…Self-perpetuating conformational conversion of the cellular prion protein PrPC into the β-sheet-rich “scrapie” conformer (PrPSc) is believed to be the central…”
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Importance of micelle‐like multimers in the atypical aggregation kinetics of N‐terminal serum amyloid A peptides by Ahmed, Ikhlaus, Jones, Eric M.

“…Amyloid formation occurs via numerous complex mechanisms, often involving intermediates. This study examines the mechanism of amyloidogenesis in two N‐terminal…”
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A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions by Cheung, Rocky, Insigne, Kimberly D., Yao, David, Burghard, Christina P., Wang, Jeffrey, Hsiao, Yun-Hua E., Jones, Eric M., Goodman, Daniel B., Xiao, Xinshu, Kosuri, Sriram

“…Mutations that lead to splicing defects can have severe consequences on gene function and cause disease. Here, we explore how human genetic variation affects…”
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Nucleation-Dependent Conformational Conversion of the Y145Stop Variant of Human Prion Protein: Structural Clues for Prion Propagation by Kundu, Bishwajit, Maiti, Nilesh R., Jones, Eric M., Surewicz, Krystyna A., Vanik, David L., Surewicz, Witold K.

“…One of the most intriguing disease-related mutations in human prion protein (PrP) is the Tyr to Stop codon substitution at position 145. This mutation results…”
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An Altered Mode of Calcium Coordination in Methionine-Oxidized Calmodulin by Jones, Eric M., Squier, Thomas C., Sacksteder, Colette A.

“…Oxidation of methionine residues in calmodulin (CaM) lowers the affinity for calcium and results in an inability to activate target proteins fully. To evaluate…”
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Role of N-terminal Familial Mutations in Prion Protein Fibrillization and Prion Amyloid Propagation in Vitro by Jones, Eric M., Surewicz, Krystyna, Surewicz, Witold K.

“…A self-perpetuating conformational conversion of the prion protein (PrP) is believed to underlie pathology and transmission of prion diseases. Here we explore…”
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HTS384 NCI60: The Next Phase of the NCI60 Screen by Kunkel, Mark W, Coussens, Nathan P, Morris, Joel, Taylor, Ronald C, Dexheimer, Thomas S, Jones, Eric M, Doroshow, James H, Teicher, Beverly A

“…The NCI60 human tumor cell line screen has been in operation as a service to the cancer research community for more than 30 years. The screen operated with…”
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Structure-Based Design of Functional Amyloid Materials by Li, Dan, Jones, Eric M, Sawaya, Michael R, Furukawa, Hiroyasu, Luo, Fang, Ivanova, Magdalena, Sievers, Stuart A, Wang, Wenyuan, Yaghi, Omar M, Liu, Cong, Eisenberg, David S

“…Amyloid fibers, once exclusively associated with disease, are acquiring utility as a class of biological nanomaterials. Here we introduce a method that…”
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Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples by Bloom, Joshua S., Sathe, Laila, Munugala, Chetan, Jones, Eric M., Gasperini, Molly, Lubock, Nathan B., Yarza, Fauna, Thompson, Erin M., Kovary, Kyle M., Park, Jimin, Marquette, Dawn, Kay, Stephania, Lucas, Mark, Love, TreQuan, Sina Booeshaghi, A., Brandenberg, Oliver F., Guo, Longhua, Boocock, James, Hochman, Myles, Simpkins, Scott W., Lin, Isabella, LaPierre, Nathan, Hong, Duke, Zhang, Yi, Oland, Gabriel, Choe, Bianca Judy, Chandrasekaran, Sukantha, Hilt, Evann E., Butte, Manish J., Damoiseaux, Robert, Kravit, Clifford, Cooper, Aaron R., Yin, Yi, Pachter, Lior, Garner, Omai B., Flint, Jonathan, Eskin, Eleazar, Luo, Chongyuan, Kosuri, Sriram, Kruglyak, Leonid, Arboleda, Valerie A.

“…Frequent and widespread testing of members of the population who are asymptomatic for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential…”
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A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing by Jones, Eric M, Jajoo, Rishi, Cancilla, Daniel, Lubock, Nathan B, Wang, Jeffrey, Satyadi, Megan, Chong, Rockie, de March, Claire, Bloom, Joshua S, Matsunami, Hiroaki, Kosuri, Sriram

“…G protein-coupled receptors (GPCRs) are central to how mammalian cells sense and respond to chemicals. Mammalian olfactory receptors (ORs), the largest family…”
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Structural polymorphism in amyloids: new insights from studies with Y145Stop prion protein fibrils by Jones, Eric M, Wu, Bo, Surewicz, Krystyna, Nadaud, Philippe S, Helmus, Jonathan J, Chen, Shugui, Jaroniec, Christopher P, Surewicz, Witold K

“…The C-terminally-truncated human prion protein variant Y145Stop (or PrP23-144), associated with a familial prion disease, provides a valuable model for…”
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Distinguishing unfolding and functional conformational transitions of calmodulin using ultraviolet resonance Raman spectroscopy by Jones, Eric M., Balakrishnan, Gurusamy, Squier, Thomas C., Spiro, Thomas G.

“…Calmodulin (CaM) is a ubiquitous moderator protein for calcium signaling in all eukaryotic cells. This small calcium‐binding protein exhibits a broad range of…”
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Amyloid-intercalated graphene oxide membranes for enhanced nanofiltration by Lin, Alice C., Xie, Fangyou, Chang, Russell, Beaver, Nicholas, Drewery, Claire, Collins, Catherine, Lehr, Corinne, Jones, Eric M., Zhang, Shanju

“…•Protein amyloid fibrils are incorporated into graphene oxide membranes via ionic interactions.•Amyloid fibrils enable to tune the interlayer spacing of…”
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Impact Erosion of Planetary Atmospheres: Some Surprising Results by Newman, William I., Symbalisty, Eugene M.D., Ahrens, Thomas J., Jones, Eric M.

“…We have investigated by analytical and computational means the effect of Cretaceous–Tertiary (K/T) size impacts (5×1030erg, 9-km-radius bolide of 1019g) on…”
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