Search Results - "Jones, Edith"

Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells by Yao, Yao, Jones, Edith, Inoki, Ken

“…The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth in eukaryotic cells. The active mTORC1 promotes cellular anabolic…”
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TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations by Maekawa, Satomi, Leigh, P. Nigel, King, Andrew, Jones, Edith, Steele, John C., Bodi, Istvan, Shaw, Christopher E., Hortobagyi, Tibor, Al-Sarraj, Safa

“…The transactive response (TAR) DNA binding protein 43 (TDP‐43) has been recently implicated as a major component of ubiquitinated inclusions in amyotrophic…”
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Structural basis for cell surface patterning through NetrinG-NGL interactions by Seiradake, Elena, Coles, Charlotte H, Perestenko, Pavel V, Harlos, Karl, McIlhinney, Robert Andrew Jeffrey, Aricescu, Alexandru Radu, Jones, Edith Yvonne

“…Brain wiring depends on cells making highly localized and selective connections through surface protein–protein interactions, including those between NetrinGs…”
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Cell guidance ligands, receptors and complexes – orchestrating signalling in time and space by Rozbesky, Daniel, Jones, Edith Yvonne

“…•Characterisation of a monomeric semaphorin.•The auto-inhibition and activation mechanism of Robo ectodomain.•Structure-guided modulation of EphA2…”
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Framework for precision phenotyping of heart failure patients using clinical data at rest and exercise by Carlson, Brian, Meyer, Andrew, Ježek, Filip, Jones, Edith, Hua, Xinwei, Hummel, Scott, Tang, Yida, Beard, Daniel

“…Abstract only Precision phenotyping of mechanistic differences between and within different types of heart failure is a valuable tool not only to understand…”
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Microphthalmia-associated transcription factors activate mTORC1 through RagD GTPase gene expression by Jones, Edith, Inoki, Ken

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Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum by Zhao, Yuguang, Ren, Jingshan, Hillier, James, Jones, Margaret, Lu, Weixian, Jones, Edith Yvonne

“…The hormone melatonin, secreted from the pineal gland, mediates multiple physiological effects including modulation of Wnt/β‐catenin signalling. The Wnt…”
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Using Model-Based Analysis and Physiology-Informed Machine Learning for Precision Phenotyping in Heart Failure by Jones, Edith

“…A model-based approach was developed to elucidate etiological differences between and within patient groups representing the two dominant heart failure…”
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The little big genome: the organization of mitochondrial DNA by Garcia, Iraselia, Jones, Edith, Ramos, Manuel, Innis-Whitehouse, Wendy, Gilkerson, Robert

“…The small (16,569 base pair) human mitochondrial genome plays a significant role in cell metabolism and homeostasis. Mitochondrial DNA (mtDNA) contributes to…”
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Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6 by Zhao, Yuguang, Ren, Jingshan, Lu, Weixian, Harlos, Karl, Jones, Edith Yvonne

“…Ly6/urokinase‐type plasminogen activator receptor (uPAR) (LU) domain containing 6 (LYPD6) is a Wnt signaling enhancer that promotes phosphorylation of the Wnt…”
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Phenotyping heart failure using model‐based analysis and physiology‐informed machine learning by Jones, Edith, Randall, E. Benjamin, Hummel, Scott L., Cameron, David M., Beard, Daniel A., Carlson, Brian E.

“…To phenotype mechanistic differences between heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction, a closed‐loop model of the…”
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Two Distinct Classes of Heart Failure with Preserved Ejection Fraction Emerge from Analysis of Standard Clinical Measures using Mechanistic Models of the Cardiovascular System by Jones, Edith, Hummel, Scott L., Cameron, David M., Beard, Daniel A., Carlson, Brian E.

“…Abstract only Diagnosis and treatment of heart failure are determined through the analysis of echocardiography (EC) and right heart catheterization (RHC)…”
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Notum – an extracellular protein deacylase that suppresses Wnt signalling by Jones, Edith Yvonne, Zebisch, Matthias, Zhao, Yuguang

“…Abstract only…”
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HONORING PROFESSOR LINO GRAGLIA: A TRIBUTE by Jones, Edith H

“…[...]even an introductory course on United States constitutional law demonstrated inconsistencies and counterintuitive results in Supreme Court case law and…”
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A threshold of transmembrane potential is required for mitochondrial dynamic balance mediated by DRP1 and OMA1 by Jones, Edith, Gaytan, Norma, Garcia, Iraselia, Herrera, Alan, Ramos, Manuel, Agarwala, Divya, Rana, Maahrose, Innis-Whitehouse, Wendy, Schuenzel, Erin, Gilkerson, Robert

“…As an organellar network, mitochondria dynamically regulate their organization via opposing fusion and fission pathways to maintain bioenergetic homeostasis…”
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Structure of the Wnt signaling enhancer LYPD 6 and its interactions with the Wnt coreceptor LRP 6 by Zhao, Yuguang, Ren, Jingshan, Lu, Weixian, Harlos, Karl, Jones, Edith Yvonne

“…Ly6/urokinase‐type plasminogen activator receptor (uPAR) (LU) domain containing 6 ( LYPD 6) is a Wnt signaling enhancer that promotes phosphorylation of the…”
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Rough justice in mass future claims: Should bankruptcy courts direct tort reform? by Jones, Edith H

“…The National Bankruptcy Review Commission was set up by the Congress in 1994 and charged with recommending reform of bankruptcy laws. Its report, issued in…”
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Using Model‐Based Analysis and Physiology‐Informed Machine Learning to Refine the Stratification of Phenotypes in Heart Failure by Jones, Edith, Randall, E. B., Hassavoort, Kiley S., Cameron, David M., Hummel, Scott L., Beard, Daniel A., Carlson, Brian E.

“…A model‐based approach was developed to elucidate etiological differences between and within patient groups representing the two dominant heart failure…”
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Biochemical and Structural Studies of ASPP Proteins Reveal Differential Binding to p53, p63, and p73 by Robinson, Ross Alexander, Lu, Xin, Jones, Edith Yvonne, Siebold, Christian

“…ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Binding assays showed differential binding for C-terminal…”
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Structural basis of semaphorin‐plexin cis interaction by Rozbesky, Daniel, Verhagen, Marieke G, Karia, Dimple, Nagy, Gergely N, Alvarez, Luis, Robinson, Ross A, Harlos, Karl, Padilla‐Parra, Sergi, Pasterkamp, R Jeroen, Jones, Edith Yvonne

“…Semaphorin ligands interact with plexin receptors to contribute to functions in the development of myriad tissues including neurite guidance and synaptic…”
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