Search Results - "Jones, David T W"

Pilocytic astrocytoma: pathology, molecular mechanisms and markers by Collins, V. Peter, Jones, David T. W., Giannini, Caterina

“…Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago. They are relatively benign (WHO grade I) and have, as a group, a…”
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Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway by Huse, Jason T., Snuderl, Matija, Jones, David T. W., Brathwaite, Carole D., Altman, Nolan, Lavi, Ehud, Saffery, Richard, Sexton-Oates, Alexandra, Blumcke, Ingmar, Capper, David, Karajannis, Matthias A., Benayed, Ryma, Chavez, Lukas, Thomas, Cheddhi, Serrano, Jonathan, Borsu, Laetitia, Ladanyi, Marc, Rosenblum, Marc K.

“…Epileptogenic tumors affecting children and young adults are a morphologically diverse collection of neuroepithelial neoplasms that, as a group, exhibit…”
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Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data by Maros, Máté E., Capper, David, Jones, David T. W., Hovestadt, Volker, von Deimling, Andreas, Pfister, Stefan M., Benner, Axel, Zucknick, Manuela, Sill, Martin

“…DNA methylation data-based precision cancer diagnostics is emerging as the state of the art for molecular tumor classification. Standards for choosing…”
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Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers by Korshunov, Andrey, Ryzhova, Marina, Hovestadt, Volker, Bender, Sebastian, Sturm, Dominik, Capper, David, Meyer, Jochen, Schrimpf, Daniel, Kool, Marcel, Northcott, Paul A., Zheludkova, Olga, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Reifenberger, Guido, Jabado, Nada, Perry, Arie, Lichter, Peter, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.

“…Pediatric glioblastoma (pedGBM) is amongst the most common malignant brain tumors of childhood and carries a dismal prognosis. In contrast to adult GBM, few…”
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Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets by Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas

“…With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of…”
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Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma by Olar, Adriana, Wani, Khalida M., Wilson, Charmaine D., Zadeh, Gelareh, DeMonte, Franco, Jones, David T. W., Pfister, Stefan M., Sulman, Erik P., Aldape, Kenneth D.

“…Meningioma is the most common primary brain tumor and carries a substantial risk of local recurrence. Methylation profiles of meningioma and their clinical…”
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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities by Reuss, David E., Kratz, Annekathrin, Sahm, Felix, Capper, David, Schrimpf, Daniel, Koelsche, Christian, Hovestadt, Volker, Bewerunge-Hudler, Melanie, Jones, David T. W., Schittenhelm, Jens, Mittelbronn, Michel, Rushing, Elisabeth, Simon, Matthias, Westphal, Manfred, Unterberg, Andreas, Platten, Michael, Paulus, Werner, Reifenberger, Guido, Tonn, Joerg-Christian, Aldape, Kenneth, Pfister, Stefan M., Korshunov, Andrey, Weller, Michael, Herold-Mende, Christel, Wick, Wolfgang, Brandner, Sebastian, von Deimling, Andreas

“…IDH wild type ( IDH wt) anaplastic astrocytomas WHO grade III (AA III) are associated with poor outcome. To address the possibilities of molecular subsets…”
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Methylation-based classification of benign and malignant peripheral nerve sheath tumors by Röhrich, Manuel, Koelsche, Christian, Schrimpf, Daniel, Capper, David, Sahm, Felix, Kratz, Annekathrin, Reuss, Jana, Hovestadt, Volker, Jones, David T. W., Bewerunge-Hudler, Melanie, Becker, Albert, Weis, Joachim, Mawrin, Christian, Mittelbronn, Michel, Perry, Arie, Mautner, Victor-Felix, Mechtersheimer, Gunhild, Hartmann, Christian, Okuducu, Ali Fuat, Arp, Mirko, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Heim, Stefanie, Paulus, Werner, Schittenhelm, Jens, Ahmadi, Rezvan, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., von Deimling, Andreas, Reuss, David E.

“…The vast majority of peripheral nerve sheath tumors derive from the Schwann cell lineage and comprise diverse histological entities ranging from benign…”
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Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity by Korshunov, Andrey, Capper, David, Reuss, David, Schrimpf, Daniel, Ryzhova, Marina, Hovestadt, Volker, Sturm, Dominik, Meyer, Jochen, Jones, Chris, Zheludkova, Olga, Kumirova, Ella, Golanov, Andrey, Kool, Marcel, Schüller, Ulrich, Mittelbronn, Michel, Hasselblatt, Martin, Schittenhelm, Jens, Reifenberger, Guido, Herold-Mende, Christel, Lichter, Peter, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.

“…In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade gliomas, H3 G34-mutant tumors present as a histopathologically…”
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Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma by Wiestler, Benedikt, Capper, David, Sill, Martin, Jones, David T. W., Hovestadt, Volker, Sturm, Dominik, Koelsche, Christian, Bertoni, Anna, Schweizer, Leonille, Korshunov, Andrey, Weiß, Elisa K., Schliesser, Maximilian G., Radbruch, Alexander, Herold-Mende, Christel, Roth, Patrick, Unterberg, Andreas, Hartmann, Christian, Pietsch, Torsten, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard, Platten, Michael, Pfister, Stefan M., von Deimling, Andreas, Weller, Michael, Wick, Wolfgang

“…The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or…”
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Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma by Sahm, Felix, Reuss, David, Koelsche, Christian, Capper, David, Schittenhelm, Jens, Heim, Stephanie, Jones, David T. W., Pfister, Stefan M., Herold-Mende, Christel, Wick, Wolfgang, Mueller, Wolf, Hartmann, Christian, Paulus, Werner, von Deimling, Andreas

“…Astrocytoma and oligodendroglioma are histologically and genetically well-defined entities. The majority of astrocytomas harbor concurrent TP53 and ATRX…”
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MAPK pathway activation in pilocytic astrocytoma by Jones, David T. W., Gronych, Jan, Lichter, Peter, Witt, Olaf, Pfister, Stefan M.

“…Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system (CNS). A body of research over recent years has demonstrated a key…”
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Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system by Koelsche, Christian, Sahm, Felix, Capper, David, Reuss, David, Sturm, Dominik, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Wiestler, Benedikt, Böhmer, Katja, Meyer, Jochen, Mawrin, Christian, Hartmann, Christian, Mittelbronn, Michel, Platten, Michael, Brokinkel, Benjamin, Seiz, Marcel, Herold-Mende, Christel, Unterberg, Andreas, Schittenhelm, Jens, Weller, Michael, Pfister, Stefan, Wick, Wolfgang, Korshunov, Andrey, von Deimling, Andreas

“…Hot spot mutations in the promoter region of telomerase reverse transcriptase ( TERT ) have recently been described in several human tumor entities. These…”
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ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma by Reuss, David E., Sahm, Felix, Schrimpf, Daniel, Wiestler, Benedikt, Capper, David, Koelsche, Christian, Schweizer, Leonille, Korshunov, Andrey, Jones, David T. W., Hovestadt, Volker, Mittelbronn, Michel, Schittenhelm, Jens, Herold-Mende, Christel, Unterberg, Andreas, Platten, Michael, Weller, Michael, Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas

“…Diffuse gliomas are represented in the 2007 WHO classification as astrocytomas, oligoastrocytomas and oligodendrogliomas of grades II and III and glioblastomas…”
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Medulloblastomics: the end of the beginning by Northcott, Paul A., Jones, David T. W., Kool, Marcel, Robinson, Giles W., Gilbertson, Richard J., Cho, Yoon-Jae, Pomeroy, Scott L., Korshunov, Andrey, Lichter, Peter, Taylor, Michael D., Pfister, Stefan M.

“…Key Points Medulloblastoma is the most common malignant paediatric brain tumour and is a leading cause of cancer-related morbidity and mortality in children…”
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Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas by Fontebasso, Adam M., Schwartzentruber, Jeremy, Khuong-Quang, Dong-Anh, Liu, Xiao-Yang, Sturm, Dominik, Korshunov, Andrey, Jones, David T. W., Witt, Hendrik, Kool, Marcel, Albrecht, Steffen, Fleming, Adam, Hadjadj, Djihad, Busche, Stephan, Lepage, Pierre, Montpetit, Alexandre, Staffa, Alfredo, Gerges, Noha, Zakrzewska, Magdalena, Zakrzewski, Krzystof, Liberski, Pawel P., Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Zadeh, Gelareh, Faury, Damien, Pfister, Stefan M., Jabado, Nada, Majewski, Jacek

“…Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30 % of HGGs). To…”
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Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis by Hasselblatt, Martin, Thomas, Christian, Hovestadt, Volker, Schrimpf, Daniel, Johann, Pascal, Bens, Susanne, Oyen, Florian, Peetz-Dienhart, Susanne, Crede, Yvonne, Wefers, Annika, Vogel, Hannes, Riemenschneider, Markus J., Antonelli, Manila, Giangaspero, Felice, Bernardo, Marie Christine, Giannini, Caterina, Ud Din, Nasir, Perry, Arie, Keyvani, Kathy, van Landeghem, Frank, Sumerauer, David, Hauser, Peter, Capper, David, Korshunov, Andrey, Jones, David T. W., Pfister, Stefan M., Schneppenheim, Reinhard, Siebert, Reiner, Frühwald, Michael C., Kool, Marcel

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Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre by Jaunmuktane, Zane, Capper, David, Jones, David T W, Schrimpf, Daniel, Sill, Martin, Dutt, Monika, Suraweera, Nirosha, Pfister, Stefan M, von Deimling, Andreas, Brandner, Sebastian

“…The introduction of the classification of brain tumours based on their DNA methylation profile has significantly changed the diagnostic approach for cases with…”
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TelomereHunter - in silico estimation of telomere content and composition from cancer genomes by Feuerbach, Lars, Sieverling, Lina, Deeg, Katharina I, Ginsbach, Philip, Hutter, Barbara, Buchhalter, Ivo, Northcott, Paul A, Mughal, Sadaf S, Chudasama, Priya, Glimm, Hanno, Scholl, Claudia, Lichter, Peter, Fröhling, Stefan, Pfister, Stefan M, Jones, David T W, Rippe, Karsten, Brors, Benedikt

“…Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular…”
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