Search Results - "Jones, David Ej"

Fatal gastrointestinal histoplasmosis 15 years after orthotopic liver transplantation by Agrawal, Nikita, Jones, David Ej, Dyson, Jessica K, Hoare, Tim, Melmore, Sharon A, Needham, Stephanie, Thompson, Nick P

“…We report a case of ileo-colonic Histoplasmosis without apparent respiratory involvement in a patient who had previously undergone an orthotopic liver…”
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Familial primary biliary cirrhosis reassessed: a geographically-based population study by Jones, David EJ, Watt, Fiona E, Metcalf, Jane V, Bassendine, Margaret F, James, Oliver F.W

“…Background/Aims: Development of primary biliary cirrhosis in the close relatives of patients with the disease has been reported in several series, suggesting a…”
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Managing cognitive symptoms and fatigue in cholestatic liver disease by Phaw, Naw April, Leighton, Jessica, Dyson, Jessica Katharine, Jones, David Ej

“…: Patients with cholestatic diseases may develop fatigue and cognitive symptoms. The impact of symptom burden may be significant in some patients. To date,…”
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Changing nomenclature for PBC: From ‘cirrhosis’ to ‘cholangitis’ by Beuers, Ulrich, Gershwin, M. Eric, Gish, Robert G., Invernizzi, Pietro, Jones, David E.J., Lindor, Keith, Ma, Xiong, Mackay, Ian R., Parés, Albert, Tanaka, Atsushi, Vierling, John M., Poupon, Raoul

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Primary biliary cholangitis drug evaluation and regulatory approval: Where do we go from here? by Jones, David Ej, Beuers, Ulrich, Bonder, Alan, Carbone, Marco, Culver, Emma, Dyson, Jessica, Gish, Robert G, Hansen, Bettina E, Hirschfield, Gideon, Jones, Rebecca, Kowdley, Kris, Kremer, Andreas E, Lindor, Keith, Mayo, Marlyn, Mells, George, Neuberger, James, Prince, Martin, Swain, Mark, Tanaka, Atsushi, Thorburn, Douglas, Trauner, Michael, Trivedi, Palak, Weltman, Martin, Yeoman, Andrew, Levy, Cynthia

“…Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease. The management landscape was transformed 20 years ago with the advent of…”
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Pembrolizumab as a Cause of Cholangiopathy in a Patient With Metastatic Melanoma by Stuart, Laura, Lambourne, Beth, Turner, Paul, Jones, David E.J., Plummer, Ruth, Cresti, Nicola, Dyson, Jessica K.

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The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis by Barron‐Millar, Ben, Ogle, Laura, Mells, George, Flack, Steven, Badrock, Jonathan, Sandford, Richard, Kirby, John, Palmer, Jeremy, Jopson, Laura, Brain, John, Smith, Graham R., Rushton, Steve, Hegade, Vinod S., Jones, Rebecca, Rushbrook, Simon, Thorburn, Douglas, Ryder, Steve, Hirschfield, Gideon, Dyson, Jessica K., Jones, David E.J.

“…Background and Aims Stratified therapy has entered clinical practice in primary biliary cholangitis (PBC), with routine use of second‐line therapy in…”
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Complications of cholestasis by Hegade, Vinod S., Jones, David EJ

“…Cholestasis (impairment of, or reduction in, bile flow) can both predispose to the development of chronic liver disease and result in its own specific…”
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Long-Term Fenofibrate Treatment in Primary Biliary Cholangitis Improves Biochemistry but Not the UK-PBC Risk Score by Hegade, Vinod S., Khanna, Amardeep, Walker, Lucy J., Wong, Lin-Lee, Dyson, Jessica K., Jones, David E. J.

“…Background Fenofibrate (FF) has been suggested as a second-line agent in primary biliary cholangitis (PBC) patients who do not achieve adequate biochemical…”
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Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis by Kendrick, Stuart F. W., O'Boyle, Graeme, Mann, Jelena, Zeybel, Mujdat, Palmer, Jeremy, Jones, David E. J., Day, Chris P.

“…Acute alcoholic hepatitis is characterized by disproportionate macrophage inflammatory cytokine responses to bacterial lipopolysaccharide. Lack of knowledge of…”
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Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up by Elliott, Chris, Frith, James, Day, Christopher P., Jones, David E. J., Newton, Julia L.

“…Background and Aims Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are common and increasing in prevalence. We examined prevalence…”
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Pathogenesis of cholestatic itch: Old questions, new answers, and future opportunities by Jones, David E.J.

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Fetal microchimerism: an aetiological factor in primary biliary cirrhosis? by Jones, David EJ

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Drug treatment of pruritus in liver diseases by Hegade, Vinod S, Kendrick, Stuart FW, Jones, David EJ

“…Pruritus (itch) is a common complication of cholestatic liver diseases (CLD). It can be a distressing and debilitating symptom, causing significant impairment…”
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Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case-control study by Jones, David E. J., Hollingsworth, Kieren G., Jakovljevic, Djordje G., Fattakhova, Gulnar, Pairman, Jessie, Blamire, Andrew M., Trenell, Michael I., Newton, Julia L.

“…Eur J Clin Invest 2011 Background  Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle…”
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UK-PBC National Audit: a collaborative success in identifying critical shortfalls by Burke, Laura, Flack, Steven, Jones, Rebecca L, Aspinall, Richard J, Heneghan, Michael A, Thorburn, Doug, Jones, David EJ, Braniff, Conor, Thain, Collette, Yeoman, Andrew, Leithead, Joanna A, Trivedi, Palak, Mells, George, Alrubaiy, Laith

“…Notably, disparities were found in the optimal dosing of ursodeoxycholic acid (UDCA), risk stratification using UDCA response, assessment of clinical symptoms…”
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Toll-like receptor (TLR) response tolerance: a key physiological "damage limitation" effect and an important potential opportunity for therapy by Broad, Andrea, Jones, David E J, Kirby, John A

“…Endotoxin tolerance is a well known phenomenon, described both in vivo and in vitro, in which repeated exposure to endotoxin results in a diminished response,…”
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Impaired cardiovascular response to standing in Chronic Fatigue Syndrome by Hollingsworth, Kieren G., Jones, David E. J., Taylor, Roy, Blamire, Andrew M., Newton, Julia L.

“…Eur J Clin Invest 2010; 40 (7): 608–615 Background  Impaired skeletal muscle metabolism is recognized in chronic fatigue syndrome (CFS). This study examined…”
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Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease by Newton, Julia L., Pairman, Jessie, Wilton, Katharine, Jones, David E. J., Day, Christopher

“…Background Fatigue is a significant symptom in non-alcoholic fatty liver disease (NAFLD) that impacts upon quality of life and is unrelated to liver disease…”
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A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis by Hegade, Vinod S, Bolier, Ruth, Oude Elferink, Ronald PJ, Beuers, Ulrich, Kendrick, Stuart, Jones, David EJ

“…Pruritus (itch) is an important symptom of primary biliary cirrhosis (PBC), an archetypal cholestatic liver disease. Cholestatic pruritus can be a debilitating…”
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