Search Results - "Jones, David"

History in a Crisis — Lessons for Covid-19 by Jones, David S

“…The history of human responses to epidemics carries various lessons for our current situation. Two of the more disheartening ones are that stigmatization…”
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Future (post-COVID) digital, smart and sustainable cities in the wake of 6G: Digital twins, immersive realities and new urban economies by Allam, Zaheer, Jones, David S.

“…•Explores the emerging subject of 6G and its associated concepts.•Dwells into the application of 6G in cities and its challenges.•Underlines future prospects…”
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Pilocytic astrocytoma: pathology, molecular mechanisms and markers by Collins, V. Peter, Jones, David T. W., Giannini, Caterina

“…Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago. They are relatively benign (WHO grade I) and have, as a group, a…”
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Setting the standards for machine learning in biology by Jones, David T.

“…Machine learning is a branch of artificial intelligence (AI) involving computer programs that are able to improve their own performance through experience…”
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ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma by Reuss, David E., Sahm, Felix, Schrimpf, Daniel, Wiestler, Benedikt, Capper, David, Koelsche, Christian, Schweizer, Leonille, Korshunov, Andrey, Jones, David T. W., Hovestadt, Volker, Mittelbronn, Michel, Schittenhelm, Jens, Herold-Mende, Christel, Unterberg, Andreas, Platten, Michael, Weller, Michael, Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas

“…Diffuse gliomas are represented in the 2007 WHO classification as astrocytomas, oligoastrocytomas and oligodendrogliomas of grades II and III and glioblastomas…”
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Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data by Maros, Máté E., Capper, David, Jones, David T. W., Hovestadt, Volker, von Deimling, Andreas, Pfister, Stefan M., Benner, Axel, Zucknick, Manuela, Sill, Martin

“…DNA methylation data-based precision cancer diagnostics is emerging as the state of the art for molecular tumor classification. Standards for choosing…”
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DISOPRED3: precise disordered region predictions with annotated protein-binding activity by Jones, David T, Cozzetto, Domenico

“…A sizeable fraction of eukaryotic proteins contain intrinsically disordered regions (IDRs), which act in unfolded states or by undergoing transitions between…”
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Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway by Huse, Jason T., Snuderl, Matija, Jones, David T. W., Brathwaite, Carole D., Altman, Nolan, Lavi, Ehud, Saffery, Richard, Sexton-Oates, Alexandra, Blumcke, Ingmar, Capper, David, Karajannis, Matthias A., Benayed, Ryma, Chavez, Lukas, Thomas, Cheddhi, Serrano, Jonathan, Borsu, Laetitia, Ladanyi, Marc, Rosenblum, Marc K.

“…Epileptogenic tumors affecting children and young adults are a morphologically diverse collection of neuroepithelial neoplasms that, as a group, exhibit…”
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Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers by Korshunov, Andrey, Ryzhova, Marina, Hovestadt, Volker, Bender, Sebastian, Sturm, Dominik, Capper, David, Meyer, Jochen, Schrimpf, Daniel, Kool, Marcel, Northcott, Paul A., Zheludkova, Olga, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Reifenberger, Guido, Jabado, Nada, Perry, Arie, Lichter, Peter, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.

“…Pediatric glioblastoma (pedGBM) is amongst the most common malignant brain tumors of childhood and carries a dismal prognosis. In contrast to adult GBM, few…”
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Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma by Olar, Adriana, Wani, Khalida M., Wilson, Charmaine D., Zadeh, Gelareh, DeMonte, Franco, Jones, David T. W., Pfister, Stefan M., Sulman, Erik P., Aldape, Kenneth D.

“…Meningioma is the most common primary brain tumor and carries a substantial risk of local recurrence. Methylation profiles of meningioma and their clinical…”
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Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management by Sturm, Dominik, Pfister, Stefan M, Jones, David T W

“…Gliomas are the most common CNS tumors in children and adolescents, and they show an extremely broad range of clinical behavior. The majority of pediatric…”
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Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge by Sturm, Dominik, Bender, Sebastian, Jones, David T. W., Lichter, Peter, Grill, Jacques, Becher, Oren, Hawkins, Cynthia, Majewski, Jacek, Jones, Chris, Costello, Joseph F., Iavarone, Antonio, Aldape, Kenneth, Brennan, Cameron W., Jabado, Nada, Pfister, Stefan M.

“…Key Points Glioblastoma is the most frequent and most aggressive malignant primary brain tumour and remains almost universally incurable in both children and…”
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The PSIPRED Protein Analysis Workbench: 20 years on by Buchan, Daniel W A, Jones, David T

“…The PSIPRED Workbench is a web server offering a range of predictive methods to the bioscience community for 20 years. Here, we present the work we have…”
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Location, location, location: The variable geography of opioid use and misuse by Jones, David

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Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets by Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas

“…With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of…”
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Pandemic stricken cities on lockdown. Where are our planning and design professionals [now, then and into the future]? by Allam, Zaheer, Jones, David S.

“…•Urban resilience must include dimensions of pandemics and health emergencies.•Pandemics impact on the livelihood of urban areas.•The role of urban planning…”
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A guide to machine learning for biologists by Greener, Joe G., Kandathil, Shaun M., Moffat, Lewis, Jones, David T.

“…The expanding scale and inherent complexity of biological data have encouraged a growing use of machine learning in biology to build informative and predictive…”
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Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities by Reuss, David E., Kratz, Annekathrin, Sahm, Felix, Capper, David, Schrimpf, Daniel, Koelsche, Christian, Hovestadt, Volker, Bewerunge-Hudler, Melanie, Jones, David T. W., Schittenhelm, Jens, Mittelbronn, Michel, Rushing, Elisabeth, Simon, Matthias, Westphal, Manfred, Unterberg, Andreas, Platten, Michael, Paulus, Werner, Reifenberger, Guido, Tonn, Joerg-Christian, Aldape, Kenneth, Pfister, Stefan M., Korshunov, Andrey, Weller, Michael, Herold-Mende, Christel, Wick, Wolfgang, Brandner, Sebastian, von Deimling, Andreas

“…IDH wild type ( IDH wt) anaplastic astrocytomas WHO grade III (AA III) are associated with poor outcome. To address the possibilities of molecular subsets…”
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Transmembrane protein topology prediction using support vector machines by Nugent, Timothy, Jones, David T

“…Alpha-helical transmembrane (TM) proteins are involved in a wide range of important biological processes such as cell signaling, transport of…”
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Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma by Sahm, Felix, Reuss, David, Koelsche, Christian, Capper, David, Schittenhelm, Jens, Heim, Stephanie, Jones, David T. W., Pfister, Stefan M., Herold-Mende, Christel, Wick, Wolfgang, Mueller, Wolf, Hartmann, Christian, Paulus, Werner, von Deimling, Andreas

“…Astrocytoma and oligodendroglioma are histologically and genetically well-defined entities. The majority of astrocytomas harbor concurrent TP53 and ATRX…”
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