Search Results - "Jones, Bryan W."

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells by Wahlin, Karl J., Maruotti, Julien A., Sripathi, Srinivasa R., Ball, John, Angueyra, Juan M., Kim, Catherine, Grebe, Rhonda, Li, Wei, Jones, Bryan W., Zack, Donald J.

“…The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of…”
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Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution by Heng, Jacob S., Rattner, Amir, Stein-O’Brien, Genevieve L., Winer, Briana L., Jones, Bryan W., Vernon, Hilary J., Goff, Loyal A., Nathans, Jeremy

“…The mammalian CNS is capable of tolerating chronic hypoxia, but cell type-specific responses to this stress have not been systematically characterized. In the…”
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Current perspective on retinal remodeling: Implications for therapeutics by Pfeiffer, Rebecca L, Jones, Bryan W

“…The retinal degenerative diseases retinitis pigmentosa and age-related macular degeneration are a leading cause of irreversible vision loss. Both present with…”
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Network architecture of gap junctional coupling among parallel processing channels in the mammalian retina by Sigulinsky, Crystal L, Anderson, James R, Kerzner, Ethan, Rapp, Christopher N, Pfeiffer, Rebecca L, Rodman, Taryn M, Emrich, Daniel P, Rapp, Kevin D, Nelson, Noah T, Lauritzen, J Scott, Meyer, Miriah, Marc, Robert E, Jones, Bryan W

“…Gap junctions are ubiquitous throughout the nervous system, mediating critical signal transmission and integration, as well as emergent network properties. In…”
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Pattern Recognition Analysis Reveals Unique Contrast Sensitivity Isocontours Using Static Perimetry Thresholds Across the Visual Field by Phu, Jack, Khuu, Sieu K, Nivison-Smith, Lisa, Zangerl, Barbara, Choi, Agnes Yiu Jeung, Jones, Bryan W, Pfeiffer, Rebecca L, Marc, Robert E, Kalloniatis, Michael

“…To determine the locus of test locations that exhibit statistically similar age-related decline in sensitivity to light increments and age-corrected contrast…”
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Distinctive synaptic structural motifs link excitatory retinal interneurons to diverse postsynaptic partner types by Yu, Wan-Qing, Swanstrom, Rachael, Sigulinsky, Crystal L., Ahlquist, Richard M., Knecht, Sharm, Jones, Bryan W., Berson, David M., Wong, Rachel O.

“…Neurons make converging and diverging synaptic connections with distinct partner types. Whether synapses involving separate partners demonstrate similar or…”
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A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury by Woodell, Alex, Jones, Bryan W, Williamson, Tucker, Schnabolk, Gloriane, Tomlinson, Stephen, Atkinson, Carl, Rohrer, Bärbel

“…Morphologic and genetic evidence exists that an overactive complement system driven by the complement alternative pathway (AP) is involved in pathogenesis of…”
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Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation by Farzad, Shayan, Kosta, Pragya, Iseri, Ege, Walston, Steven T, Bouteiller, Jean-Marie C., Pfeiffer, Rebecca L., Sigulinsky, Crystal L., Yang, Jia-Hui, Garcia, Jessica C., Anderson, James R., Jones, Bryan W., Lazzi, Gianluca

“…In retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), the photoreceptors become stressed and start to…”
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Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration by Barabas, Peter, Liu, Aihua, Xing, Wei, Chen, Ching-Kang, Tong, Zongzhong, Watt, Carl B., Jones, Bryan W., Bernstein, Paul S., Križaj, David

“…Stargardt type 3 (STGD3) disease is a juvenile macular dystrophy caused by mutations in the ELOVL4 (Elongation of very long chain fatty acids 4) gene. Its…”
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Generation of an inbred miniature pig model of retinitis pigmentosa by Ross, Jason W, Fernandez de Castro, Juan P, Zhao, Jianguo, Samuel, Melissa, Walters, Eric, Rios, Cecilia, Bray-Ward, Patricia, Jones, Bryan W, Marc, Robert E, Wang, Wei, Zhou, Liang, Noel, Jennifer M, McCall, Maureen A, DeMarco, Paul J, Prather, Randall S, Kaplan, Henry J

“…The Pro23His (P23H) rhodopsin (RHO) mutation underlies the most common form of human autosomal dominant retinitis pigmentosa (adRP). The objective of this…”
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Contrast sensitivity isocontours of the central visual field by Choi, Agnes Y. J., Nivison-Smith, Lisa, Phu, Jack, Zangerl, Barbara, Khuu, Sieu K., Jones, Bryan W., Pfeiffer, Rebecca L., Marc, Robert E., Kalloniatis, Michael

“…Standard automated perimetry (SAP), the most common form of perimetry used in clinical practice, is associated with high test variability, impacting clinical…”
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Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury by Woodell, Alex, Coughlin, Beth, Kunchithapautham, Kannan, Casey, Sarah, Williamson, Tucker, Ferrell, W Drew, Atkinson, Carl, Jones, Bryan W, Rohrer, Bärbel

“…Age-related macular degeneration (AMD), a complex disease involving genetic variants and environmental insults, is among the leading causes of blindness in…”
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Restoration of retinal structure and function after selective photocoagulation by Sher, Alexander, Jones, Bryan W, Huie, Philip, Paulus, Yannis M, Lavinsky, Daniel, Leung, Loh-Shan S, Nomoto, Hiroyuki, Beier, Corinne, Marc, Robert E, Palanker, Daniel

“…CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond to injury. Plasticity in the adult mammalian retina…”
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Unbalanced redox status network as an early pathological event in congenital cataracts by Bejarano, Eloy, Whitcomb, Elizabeth A., Pfeiffer, Rebecca L., Rose, Kristie L., Asensio, Maria José, Rodríguez-Navarro, José Antonio, Ponce-Mora, Alejandro, Canto, Antolín, Almansa, Inma, Schey, Kevin L., Jones, Bryan W., Taylor, Allen, Rowan, Sheldon

“…The lens proteome undergoes dramatic composition changes during development and maturation. A defective developmental process leads to congenital cataracts…”
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A computational framework for ultrastructural mapping of neural circuitry by Anderson, James R, Jones, Bryan W, Yang, Jia-Hui, Shaw, Marguerite V, Watt, Carl B, Koshevoy, Pavel, Spaltenstein, Joel, Jurrus, Elizabeth, U V, Kannan, Whitaker, Ross T, Mastronarde, David, Tasdizen, Tolga, Marc, Robert E

“…Circuitry mapping of metazoan neural systems is difficult because canonical neural regions (regions containing one or more copies of all components) are large,…”
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Pathoconnectome Analysis of Müller Cells in Early Retinal Remodeling by Pfeiffer, Rebecca L, Anderson, James R, Emrich, Daniel P, Dahal, Jeebika, Sigulinsky, Crystal L, Morrison, Hope A B, Yang, Jia-Hui, Watt, Carl B, Rapp, Kevin D, Kondo, Mineo, Terasaki, Hiroko, Garcia, Jessica C, Marc, Robert E, Jones, Bryan W

“…Glia play important roles in neural function, including but not limited to amino acid recycling, ion homeostasis, glucose metabolism, and waste removal. During…”
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ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina by Lauritzen, J. Scott, Anderson, James R., Jones, Bryan W., Watt, Carl B., Mohammed, Shoeb, Hoang, John V., Marc, Robert E.

“…Analysis of the rabbit retinal connectome RC1 reveals that the division between the ON and the OFF inner plexiform layer (IPL) is not structurally absolute. ON…”
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Retinal remodeling triggered by photoreceptor degenerations by Jones, Bryan W., Watt, Carl B., Frederick, Jeanne M., Baehr, Wolfgang, Chen, Ching-Kang, Levine, Edward M., Milam, Ann H., Lavail, Matthew M., Marc, Robert E.

“…Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It has long been assumed that the surviving neural retina is largely…”
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Different Toll-like receptor agonists induce distinct macrophage responses by Jones, Bryan W., Means, Terry K., Heldwein, Kurt A., Keen, Marc A., Hill, Preston J., Belisle, John T., Fenton, Matthew J.

“…We previously reported that gram‐negative bacterial lipopolysaccharide (LPS) activates cells via Toll‐like receptor (TLR) 4, whereas the mycobacterial cell…”
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An update on retinal prostheses by Ayton, Lauren N., Barnes, Nick, Dagnelie, Gislin, Fujikado, Takashi, Goetz, Georges, Hornig, Ralf, Jones, Bryan W., Muqit, Mahiul M.K., Rathbun, Daniel L., Stingl, Katarina, Weiland, James D., Petoe, Matthew A.

“…•Retinal prostheses have now been implanted in over 500 people with profound vision loss.•They are suitable for people with vision loss from outer retinal…”
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