Search Results - "Jones, Britta E."

Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles by Long, Sarah Alice, Muir, Virginia S, Jones, Britta E, Wall, Valerie Z, Ylescupidez, Alyssa, Hocking, Anne M, Pribitzer, Stephan, Thorpe, Jerill, Fuchs, Bryce, Wiedeman, Alice E, Tatum, Megan, Lambert, Katharina, Uchtenhagen, Hannes, Speake, Cate, Ng, Bernard, Heubeck, Alexander T, Torgerson, Troy R, Savage, Adam K, Maldonado, Michael A, Ray, Neelanjana, Khaychuk, Vadim, Liu, Jinqi, Linsley, Peter S, Buckner, Jane H

“…Exhausted CD8 T cells (T ) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT…”
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IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation by Lambert, Katharina, Diggins, Kirsten E, Jones, Britta E, Hundhausen, Christian, Maerz, Megan D, Hocking, Anne M, Sanda, Srinath, Greenbaum, Carla J, Linsley, Peter S, Cerosaletti, Karen, Buckner, Jane H

“…Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To…”
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IL-6-targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function by Speake, Cate, Habib, Tania, Lambert, Katharina, Hundhausen, Christian, Lord, Sandra, Dufort, Matthew J, Skinner, Samuel O, Hu, Alex, Kinsman, MacKenzie, Jones, Britta E, Maerz, Megan D, Tatum, Megan, Hocking, Anne M, Nepom, Gerald T, Greenbaum, Carla J, Buckner, Jane H

“…Therapeutics that inhibit IL-6 at different points in its signaling pathway are in clinical use, yet whether the immunological effects of these interventions…”
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IL-6: a cytokine at the crossroads of autoimmunity by Jones, Britta E, Maerz, Megan D, Buckner, Jane H

“…•IL-6 promotes development of Th17 and Tfh cells and suppresses induction of Treg.•IL-6 signals via three distinct mechanisms: classical, trans signaling and…”
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Fewer LAG-3 + T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes by Jones, Britta E, Maerz, Megan D, Bahnson, Henry T, Somasundaram, Ashwin, McCarthy, Lucas H, Speake, Cate, Buckner, Jane H

“…The coinhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint molecule that negatively regulates T cell activation, proliferation, and…”
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Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Have Defective Treg Cell Function Exacerbated by the Presence of a Suppression‐Resistant Effector Cell Population by Free, Meghan E., Bunch, Donna O'Dell, McGregor, Julie Anne, Jones, Britta E., Berg, Elisabeth A., Hogan, Susan L., Hu, Yichun, Preston, Gloria A., Jennette, J. Charles, Falk, Ronald J., Su, Maureen A.

“…Objective The development of pathogenic antineutrophil cytoplasmic antibodies (ANCAs) can result in systemic small vessel vasculitis. However, the breakdown in…”
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Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated Vasculitis by Jones, Britta E, Yang, Jiajin, Muthigi, Akhil, Hogan, Susan L, Hu, Yichun, Starmer, Joshua, Henderson, Candace D, Poulton, Caroline J, Brant, Elizabeth J, Pendergraft, 3rd, William F, Jennette, J Charles, Falk, Ronald J, Ciavatta, Dominic J

“…ANCA-associated vasculitis is an autoimmune condition characterized by vascular inflammation and organ damage. Pharmacologically induced remission of this…”
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Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis by Yang, Jiajin, Ge, Heng, Poulton, Caroline J, Hogan, Susan L, Hu, Yichun, Jones, Britta E, Henderson, Candace D, McInnis, Elizabeth A, Pendergraft, 3rd, William F, Jennette, J Charles, Falk, Ronald J, Ciavatta, Dominic J

“…Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by destructive vascular…”
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T cells in relapsing-remitting multiple sclerosis demonstrate diminished expression of LAG-3 by Jones, Britta E, Maerz, Megan D, Somasundaram, Ashwin, Buckner, Jane H

“…The co-inhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint molecule that negatively regulates T cell activation, proliferation,…”
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ANCA-associated Vasculitis Patients Have Defective Treg Function Exacerbated by Presence of a Suppression-Resistant Effector Population by Free, Meghan E, Bunch, Donna O, McGregor, JulieAnne, Jones, Britta E, Berg, Elisabeth A, Hogan, Susan L, Hu, Yichun, Preston, Gloria A, Jennette, J. Charles, Falk, Ronald J, Su, Maureen A

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