Search Results - "Jones, Alex R."

Vertebrate Cryptochromes are Vestigial Flavoproteins by Kutta, Roger J., Archipowa, Nataliya, Johannissen, Linus O., Jones, Alex R., Scrutton, Nigel S.

“…All cryptochromes are currently classified as flavoproteins. In animals their best-described role is as components of the circadian clock. This circadian…”
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Highlighter: An optogenetic system for high-resolution gene expression control in plants by Larsen, Bo, Hofmann, Roberto, Camacho, Ines S, Clarke, Richard W, Lagarias, J Clark, Jones, Alex R, Jones, Alexander M

“…Optogenetic actuators have revolutionized the resolution at which biological processes can be controlled. In plants, deployment of optogenetics is challenging…”
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Magnetic Fields Modulate Blue-Light-Dependent Regulation of Neuronal Firing by Cryptochrome by Giachello, Carlo N G, Scrutton, Nigel S, Jones, Alex R, Baines, Richard A

“…Many animals are able to sense the Earth's geomagnetic field to enable behaviors such as migration. It is proposed that the magnitude and direction of the…”
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Editorial: Structure-function metrology of proteins by Jones, Alex R, Moraes, Isabel, Quaglia, Milena

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Updated structure of Drosophila cryptochrome by Levy, Colin, Zoltowski, Brian D., Jones, Alex R., Vaidya, Anand T., Top, Deniz, Widom, Joanne, Young, Michael W., Scrutton, Nigel S., Crane, Brian R., Leys, David

“…Arising from B. D. Zoltowski et al. Nature480, 396–399 (2011)10.1038/nature10618 Recently, we determined the X-ray crystal structure of full-length…”
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A Green-Light-Responsive System for the Control of Transgene Expression in Mammalian and Plant Cells by Chatelle, Claire, Ochoa-Fernandez, Rocio, Engesser, Raphael, Schneider, Nils, Beyer, Hannes M, Jones, Alex R, Timmer, Jens, Zurbriggen, Matias D, Weber, Wilfried

“…The ever-increasing complexity of synthetic gene networks and applications of synthetic biology requires precise and orthogonal gene expression systems. Of…”
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Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae by Marley, Richard, Giachello, Carlo N. G., Scrutton, Nigel S., Baines, Richard A., Jones, Alex R.

“…The mechanisms that facilitate animal magnetoreception have both fascinated and confounded scientists for decades and its precise biophysical origin remains…”
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Two photon spectroscopy and microscopy of the fluorescent flavoprotein, iLOV by Homans, Rachael J, Khan, Raja U, Andrews, Michael B, Kjeldsen, Annemette E, Natrajan, Louise S, Marsden, Steven, McKenzie, Edward A, Christie, John M, Jones, Alex R

“…LOV-domains are ubiquitous photosensory proteins that are commonly re-engineered to serve as powerful and versatile fluorescent proteins and optogenetic tools…”
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Relating localized protein motions to the reaction coordinate in coenzyme B12‐dependent enzymes by Jones, Alex R., Levy, Colin, Hay, Sam, Scrutton, Nigel S.

“…The classical picture of enzyme catalysis relies on controlling the entropic and enthalpic contributions by manipulating reaction barriers and co‐locating…”
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The photochemistry and photobiology of vitamin B 12 by Jones, Alex R

“…Biologically active derivatives of vitamin B are organometallic cobalt-corrinoid complexes crucial for the healthy function of humans, animals and microbes…”
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Assessing the Covalent Attachment and Energy Transfer Capabilities of Upconverting Phosphors With Cofactor Containing Bioactive Enzymes by Burgess, Letitia, Wilson, Hannah, Jones, Alex R, Hay, Sam, Natrajan, Louise S

“…Upconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive…”
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Protein Motions Are Coupled to the Reaction Chemistry in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase by Russell, Henry J., Jones, Alex R., Hay, Sam, Greetham, Gregory M., Towrie, Michael, Scrutton, Nigel S.

“…The role of protein dynamics in promoting catalysis is hotly debated. Infrared data from both ultrafast flash photolysis and stopped‐flow studies show that not…”
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Exploiting the Fruitfly, Drosophila melanogaster, to Identify the Molecular Basis of Cryptochrome-Dependent Magnetosensitivity by Bradlaugh, Adam, Munro, Anna L., Jones, Alex R., Baines, Richard A.

“…The flavoprotein CRYPTOCHROME (CRY) is now generally believed to be a magnetosensor, providing geomagnetic information via a quantum effect on a…”
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Magnetic field effects in proteins by Jones, Alex R.

“…Many animals can sense the geomagnetic field, which appears to aid in behaviours such as migration. The influence of man-made magnetic fields on biology,…”
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Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability by Vieira, Jacqueline, Jones, Alex R, Danon, Antoine, Sakuma, Michiyo, Hoang, Nathalie, Robles, David, Tait, Shirley, Heyes, Derren J, Picot, Marie, Yoshii, Taishi, Helfrich-Förster, Charlotte, Soubigou, Guillaume, Coppee, Jean-Yves, Klarsfeld, André, Rouyer, Francois, Scrutton, Nigel S, Ahmad, Margaret

“…Cryptochromes are conserved flavoprotein receptors found throughout the biological kingdom with diversified roles in plant development and entrainment of the…”
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Magnetic Field Effect Studies Indicate Reduced Geminate Recombination of the Radical Pair in Substrate-Bound Adenosylcobalamin-Dependent Ethanolamine Ammonia Lyase by Jones, Alex R, Hay, Sam, Woodward, Jonathan R, Scrutton, Nigel S

“…The apparent conflict between literature evidence for (i) radical pair (RP) stabilization in adenosylcobalamin (AdoCbl)-dependent enzymes and (ii) the…”
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Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme by Chen, Zhi-Gang, Ziętek, Monika A, Russell, Henry J., Tait, Shirley, Hay, Sam, Jones, Alex R., Scrutton, Nigel S.

“…Radical control: A single glutamate residue (E287) in the coenzyme B12‐dependent ethanolamine ammonia lyase is pivotal to generating high‐energy radical…”
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The photochemical mechanism of a B12-dependent photoreceptor protein by Kutta, Roger J., Hardman, Samantha J. O., Johannissen, Linus O., Bellina, Bruno, Messiha, Hanan L., Ortiz-Guerrero, Juan Manuel, Elías-Arnanz, Montserrat, Padmanabhan, S., Barran, Perdita, Scrutton, Nigel S., Jones, Alex R.

“…The coenzyme B 12 -dependent photoreceptor protein, CarH, is a bacterial transcriptional regulator that controls the biosynthesis of carotenoids in response to…”
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Essential elements of radical pair magnetosensitivity in Drosophila by Bradlaugh, Adam A., Fedele, Giorgio, Munro, Anna L., Hansen, Celia Napier, Hares, John M., Patel, Sanjai, Kyriacou, Charalambos P., Jones, Alex R., Rosato, Ezio, Baines, Richard A.

“…Many animals use Earth’s magnetic field (also known as the geomagnetic field) for navigation 1 . The favoured mechanism for magnetosensitivity involves a…”
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Covalent Attachment of Active Enzymes to Upconversion Phosphors Allows Ratiometric Detection of Substrates by Burgess, Letitia, Wilson, Hannah, Jones, Alex R., Harvey, Peter, Natrajan, Louise S., Hay, Sam

“…Upconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive…”
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