Search Results - "Jonathan Sussman"

The yin and yang of pioneer transcription factors: Dual roles in repression and activation by Katsuda, Takeshi, Sussman, Jonathan H., Zaret, Kenneth S., Stanger, Ben Z.

“…Pioneer transcription factors, by virtue of their ability to target nucleosomal DNA in silent chromatin, play crucial roles in eliciting cell fate decisions…”
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Challenges and advice for MD/PhD applicants who are underrepresented in medicine by Bannerman, Carl, Guzman, Natalie, Kumar, Rachit, Nnebe, Chelsea, Setayesh, Jordan, Venapally, Amitej, Sussman, Jonathan H

“…The importance of diversity is self-evident in medicine and medical research. Not only does diversity result in more impactful scientific work, but diverse…”
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Trajectory of Performance Status and Symptom Scores for Patients With Cancer During the Last Six Months of Life by SEOW, Hsien, BARBERA, Lisa, SUTRADHAR, Rinku, HOWELL, Doris, DUDGEON, Deborah, ATZEMA, Clare, YING LIU, HUSAIN, Amna, SUSSMAN, Jonathan, EARLE, Craig

“…Ontario's cancer system is unique because it has implemented two standardized assessment tools population-wide to improve care: the Edmonton Symptom Assessment…”
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The expanding role of primary care in cancer control by Rubin, Greg, Prof, Berendsen, Annette, PhD, Crawford, S Michael, MD, Dommett, Rachel, PhD, Earle, Craig, Prof, Emery, Jon, Prof, Fahey, Tom, Prof, Grassi, Luigi, Prof, Grunfeld, Eva, Prof, Gupta, Sumit, MD, Hamilton, Willie, Prof, Hiom, Sara, PhD, Hunter, David, Prof, Lyratzopoulos, Georgios, MD, Macleod, Una, Prof, Mason, Robert, Prof, Mitchell, Geoffrey, Prof, Neal, Richard D, Prof, Peake, Michael, FRCP, Roland, Martin, Prof, Seifert, Bohumil, PhD, Sisler, Jeff, Prof, Sussman, Jonathan, MD, Taplin, Stephen, MD, Vedsted, Peter, Prof, Voruganti, Teja, MSc, Walter, Fiona, MD, Wardle, Jane, Prof, Watson, Eila, Prof, Weller, David, Prof, Wender, Richard, MD, Whelan, Jeremy, Prof, Whitlock, James, Prof, Wilkinson, Clare, Prof, de Wit, Niek, Prof, Zimmermann, Camilla, PhD

“…Summary The nature of cancer control is changing, with an increasing emphasis, fuelled by public and political demand, on prevention, early diagnosis, and…”
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Common Components of Efficacious In-Home End-of-Life Care Programs: A Review of Systematic Reviews by Bainbridge, Daryl, Seow, Hsien, Sussman, Jonathan

“…Multiple randomized controlled trials on in‐home end‐of‐life (EOL) programs, often with multifaceted and varying components, have shown benefits and reduced…”
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Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12 by Crump, Michael, Kuruvilla, John, Couban, Stephen, MacDonald, David A, Kukreti, Vishal, Kouroukis, C Tom, Rubinger, Morel, Buckstein, Rena, Imrie, Kevin R, Federico, Massimo, Di Renzo, Nicola, Howson-Jan, Kang, Baetz, Tara, Kaizer, Leonard, Voralia, Michael, Olney, Harold J, Turner, A Robert, Sussman, Jonathan, Hay, Annette E, Djurfeldt, Marina S, Meyer, Ralph M, Chen, Bingshu E, Shepherd, Lois E

“…For patients with relapsed or refractory aggressive lymphoma, we hypothesized that gemcitabine-based therapy before autologous stem-cell transplantation (ASCT)…”
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Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity by Katsuda, Takeshi, Sussman, Jonathan H., Ito, Kenji, Katznelson, Andrew, Yuan, Salina, Takenaka, Naomi, Li, Jinyang, Merrell, Allyson J., Cure, Hector, Li, Qinglan, Rasool, Reyaz Ur, Asangani, Irfan A., Zaret, Kenneth S., Stanger, Ben Z.

“…Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated…”
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Virtual Care in Patients with Cancer: A Systematic Review by Singh, Simron, Fletcher, Glenn G., Yao, Xiaomei, Sussman, Jonathan

“…Virtual care in cancer care existed in a limited fashion globally before the COVID-19 pandemic, mostly driven by geographic constraints. The pandemic has…”
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Meta-Analysis of Age, Sex, and Race Disparities in the Era of Contemporary Urothelial Carcinoma Treatment by Barsouk, Adam, Elghawy, Omar, Yang, Austin, Sussman, Jonathan H, Mamtani, Ronac, Mei, Lin

“…Urothelial carcinoma (UC) is one of the most common cancers diagnosed worldwide. However, minority populations, such as female, elder, and Black patients, may…”
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Evaluating Survivorship Care Plans: Results of a Randomized, Clinical Trial of Patients With Breast Cancer by GRUNFELD, Eva, JULIAN, Jim A, PORTER, Geoffrey A, PASZAT, Lawrence F, PRITCHARD, Kathleen I, ROBIDOUX, Andre, SMITH, Sally, SUSSMAN, Jonathan, DENT, Susan, SISLER, Jeffrey, WIERNIKOWSKI, Jennifer, LEVINE, Mark N, POND, Gregory, MAUNSELL, Elizabeth, COYLE, Douglas, FOLKES, Amy, JOY, Anil A, PROVENCHER, Louise, RAYSON, Daniel, RHEAUME, Dorianne E

“…An Institute of Medicine report recommends that patients with cancer receive a survivorship care plan (SCP). The trial objective was to determine if an SCP for…”
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Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer by Sussman, Jonathan H, Kim, Nathalia, Kemp, Samantha B, Traum, Daniel, Katsuda, Takeshi, Kahn, Benjamin M, Xu, Jason, Kim, Il-Kyu, Eskandarian, Cody, Delman, Devora, Beatty, Gregory L, Kaestner, Klaus H, Simpson, Amber L, Stanger, Ben Z

“…Oncogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) are driven by complex interactions between the neoplastic component and the tumor…”
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Optic Nerve Sheath Diameter on Computed Tomography Scans Reflects Elevated Intracranial Pressure in Patients with Craniosynostosis by Romeo, Dominic J, Sussman, Jonathan H, Massenburg, Benjamin B, Halverson, Mark, Ng, Jinggang J, Wu, Meagan, Liu, Grant T, Bartlett, Scott P, Taylor, Jesse A, Swanson, Jordan W

“…Assessment for elevated intracranial pressure (ICP) helps guide interventional decision-making to treat craniosynostosis. However, non-invasive techniques for…”
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AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture by Zheng, Dongqing, Sussman, Jonathan H, Jeon, Matthew P, Parrish, Sydney T, MacMullan, Melanie A, Delfarah, Alireza, Graham, Nicholas A

“…Oncogenes can create metabolic vulnerabilities in cancer cells. We tested how AKT (herein referring to AKT1) and MYC affect the ability of cells to shift…”
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Morphometric measurements of intraoral anatomy in children with Beckwith-Wiedemann syndrome: a novel approach by Romeo, Dominic J, George, Andrew M, Sussman, Jonathan H, Banala, Manisha, Wiemken, Andrew, Wu, Meagan, Ng, Jinggang J, Taylor, Jesse A, Schwab, Richard J, Cielo, Christopher M, Kalish, Jennifer M

“…An easy-to-use tool to objectively measure intraoral anatomy with meaningful clinical correlations may improve care for patients with Beckwith-Wiedemann…”
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Retrospective Cohort Study of Novel Oral Agents Lenalidomide and Duvelisib For Relapsed or Refractory Mycosis Fungoides and Sézary Syndrome by Elghawy, Omar, Yang, Austin G., Sussman, Jonathan H., Thomas, Colin J., Carter, Jordan S., Landsburg, Daniel J., Svoboda, Jakub, Kim, Ellen, Rook, Alain H., Chung, Jina, Villasenor-Park, Jennifer, Plastaras, John P., LaRiviere, Michael, Hubbeling, Harper, Chelius, Monica, Nasta, Sunita D., Chong, Elise A., Schuster, Stephen J., Barta, Stefan K.

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Symptom burden in transplant ineligible patients with newly diagnosed multiple myeloma: a population-based cohort study by Mian, Hira S, Pond, Gregory R, Wildes, Tanya M, Sivapathasundaram, Branavan, Sussman, Jonathan, Seow, Hsien

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Understanding the Attitudes and Beliefs of Oncologists Regarding the Transitioning and Sharing of Survivorship Care by Coschi, Courtney H, Bainbridge, Daryl, Sussman, Jonathan

“…Transitioning survivorship care from oncologists to primary care physicians (PCPs) is a reasonable alternative to oncologist-led care. This study assessed…”
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Dissecting the tumor microenvironment of epigenetically driven gliomas: Opportunities for single-cell and spatial multiomics by Sussman, Jonathan H, Xu, Jason, Amankulor, Nduka, Tan, Kai

“…Abstract Malignant gliomas are incurable brain neoplasms with dismal prognoses and near-universal fatality, with minimal therapeutic progress despite billions…”
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Optimizing Cancer Survivorship Care: Examination of Factors Associated with Transition to Primary Care by Mukherjee, Som D, Bainbridge, Daryl, Hillis, Christopher, Sussman, Jonathan

“…Healthcare systems in Canada and elsewhere have identified the need to develop methods to effectively and safely transition appropriate cancer survivors to…”
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Genetic Heterogeneity, Craniofacial Surgical Burden, and Surgical Techniques in Patients With Saethre-Chotzen Syndrome by Romeo, Dominic J, Oral, Kaan T, Massenburg, Benjamin B, Ng, Jinggang J, Wu, Meagan, Sussman, Jonathan H, Du, Steven, Bartlett, Scott P, Swanson, Jordan W, Taylor, Jesse A

“…While genotype correlates with phenotype in patients with many forms of syndromic craniosynostosis, the relationship between molecular diagnosis and…”
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