Search Results - "Jonathan N W N Barker"

Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible and Ineligible Patients in BADBIR by Mason, Kayleigh J, Barker, Jonathan N W N, Smith, Catherine H, Hampton, Philip J, Lunt, Mark, McElhone, Kathleen, Warren, Richard B, Yiu, Zenas Z N, Griffiths, Christopher E M, Burden, A David

“…Patients with psoriasis enrolled in clinical trials of biologics may not be representative of the real-world population. There is evidence that patients…”
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Psoriasis by Griffiths, Christopher E M, Armstrong, April W, Gudjonsson, Johann E, Barker, Jonathan N W N

“…Psoriasis is a common, chronic papulosquamous skin disease occurring worldwide, presenting at any age, and leading to a substantial burden for individuals and…”
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Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease by Choy, Shern Ping, Kim, Byung Jin, Paolino, Alexandra, Tan, Wei Ren, Lim, Sarah Man Lin, Seo, Jessica, Tan, Sze Ping, Francis, Luc, Tsakok, Teresa, Simpson, Michael, Barker, Jonathan N. W. N., Lynch, Magnus D., Corbett, Mark S., Smith, Catherine H., Mahil, Satveer K.

“…Skin diseases affect one-third of the global population, posing a major healthcare burden. Deep learning may optimise healthcare workflows through processing…”
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Polymorphisms in Folate, Pyrimidine, and Purine Metabolism Are Associated with Efficacy and Toxicity of Methotrexate in Psoriasis by Campalani, Emanuela, Arenas, Monica, Marinaki, Anthony M., Lewis, Cathryn M., Barker, Jonathan N.W.N., Smith, Catherine H.

“…Methotrexate is the gold standard therapy for moderate to severe psoriasis, but there is marked interpersonal variation in its efficacy and toxicity. We…”
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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci by Ellinghaus, David, Jostins, Luke, Spain, Sarah L, Cortes, Adrian, Bethune, Jörn, Han, Buhm, Park, Yu Rang, Raychaudhuri, Soumya, Pouget, Jennie G, Hübenthal, Matthias, Folseraas, Trine, Wang, Yunpeng, Esko, Tonu, Metspalu, Andres, Westra, Harm-Jan, Franke, Lude, Pers, Tune H, Weersma, Rinse K, Collij, Valerie, D'Amato, Mauro, Halfvarson, Jonas, Jensen, Anders Boeck, Lieb, Wolfgang, Degenhardt, Franziska, Forstner, Andreas J, Hofmann, Andrea, Schreiber, Stefan, Mrowietz, Ulrich, Juran, Brian D, Lazaridis, Konstantinos N, Brunak, Søren, Dale, Anders M, Trembath, Richard C, Weidinger, Stephan, Weichenthal, Michael, Ellinghaus, Eva, Elder, James T, Barker, Jonathan N W N, Andreassen, Ole A, McGovern, Dermot P, Karlsen, Tom H, Barrett, Jeffrey C, Parkes, Miles, Brown, Matthew A, Franke, Andre

“…David Ellinghaus and colleagues report a combined association analysis of five chronic inflammatory diseases. They identify 27 new associations and highlight…”
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Mutations in the γ-Secretase Genes NCSTN, PSENEN, and PSEN1 Underlie Rare Forms of Hidradenitis Suppurativa (Acne Inversa) by Pink, Andrew E., Simpson, Michael A., Desai, Nemesha, Dafou, Dimitra, Hills, Alison, Mortimer, Peter, Smith, Catherine H., Trembath, Richard C., Barker, Jonathan N.W.

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Interaction between Genetic Control of Vascular Endothelial Growth Factor Production and Retinoid Responsiveness in Psoriasis by Young, Helen S., Summers, Angela M., Read, Ian R., Fairhurst, David A., Plant, Darren J., Campalani, Emanuela, Smith, Catherine H., Barker, Jonathan N.W.N., Detmar, Michael J., Brenchley, Paul E.C., Griffiths, Christopher E.M.

“…Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and −460,…”
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Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects by Saunders, Sean P., PhD, Goh, Christabelle S.M., BSc, Brown, Sara J., MD, Palmer, Colin N.A., PhD, Porter, Rebecca M., PhD, Cole, Christian, PhD, Campbell, Linda E., MSc, Gierlinski, Marek, PhD, Barton, Geoffrey J., PhD, Schneider, Georg, PhD, Balmain, Allan, PhD, Prescott, Alan R., PhD, Weidinger, Stephan, MD, PhD, Baurecht, Hansjörg, PhD, Kabesch, Michael, MD, Gieger, Christian, PhD, Lee, Young-Ae, MD, Tavendale, Roger, PhD, Mukhopadhyay, Somnath, MD, Turner, Stephen W., MD, Madhok, Vishnu B., MD, Sullivan, Frank M., MD, Relton, Caroline, PhD, Burn, John, MD, Meggitt, Simon, MD, Smith, Catherine H., MD, Allen, Michael A., PhD, Barker, Jonathan N.W. N., MD, Reynolds, Nick J., MD, Cordell, Heather J., DPhil, Irvine, Alan D., MD, McLean, W.H. Irwin, DSc, Sandilands, Aileen, PhD, Fallon, Padraic G., PhD

“…Background Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin…”
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PSENEN and NCSTN Mutations in Familial Hidradenitis Suppurativa (Acne Inversa) by Pink, Andrew E., Simpson, Michael A., Brice, Glen W., Smith, Catherine H., Desai, Nemesha, Mortimer, Peter S., Barker, Jonathan N.W.N., Trembath, Richard C.

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Genetic Association Analysis Using Data from Triads and Unrelated Subjects by Epstein, Michael P., Veal, Colin D., Trembath, Richard C., Barker, Jonathan N.W.N., Li, Chun, Satten, Glen A.

“…The selection of an appropriate control sample for use in association mapping requires serious deliberation. Unrelated controls are generally easy to collect,…”
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Genetic Variation in Efflux Transporters Influences Outcome to Methotrexate Therapy in Patients with Psoriasis by Warren, Richard B., Smith, Rhodri Ll, Campalani, Emanuela, Eyre, Steve, Smith, Catherine H., Barker, Jonathan N.W.N., Worthington, Jane, Griffiths, Christopher E.M.

“…Methotrexate, an inexpensive first-line systemic therapy for moderate-to-severe psoriasis, is limited in its use by unpredictable efficacy and toxicity. This…”
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Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood by Barker, Jonathan N.W.N., Palmer, Colin N.A., Zhao, Yiwei, Liao, Haihui, Hull, Peter R., Lee, Simon P., Allen, Michael H., Meggitt, Simon J., Reynolds, Nicholas J., Trembath, Richard C., Irwin McLean, W.H.

“…Atopic dermatitis (AD) is a common disease with a complex etiology in childhood and adult life. A significant proportion of childhood AD is transient, but in…”
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Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5) , kallikrein-related peptidase 7 (KLK7) , and filaggrin (FLG) polymorphisms to eczema risk by Weidinger, Stephan, MD, PhD, Baurecht, Hansjörg, MSc, Wagenpfeil, Stefan, PhD, Henderson, John, MD, Novak, Natalija, MD, Sandilands, Aileen, PhD, Chen, Huijia, BSc, Rodriguez, Elke, PhD, O'Regan, Grainne M., MRCPI, Watson, Rosemarie, MD, Liao, Haihui, MD, Zhao, Yiwei, MD, Barker, Jonathan N.W.N., MD, Allen, Michael, PhD, Reynolds, Nick, MD, Meggitt, Simon, MD, Northstone, Kate, PhD, Smith, George D., DSc, Strobl, Carolin, MSc, Stahl, Caroline, MSc, Kneib, Thomas, PhD, Klopp, Norman, PhD, Bieber, Thomas, MD, Behrendt, Heidrun, MD, Palmer, Colin N.A., PhD, Wichmann, H.-Erich, MD, Ring, Johannes, MD, Illig, Thomas, PhD, McLean, W.H. Irwin, PhD, DSc, FRSE, Irvine, Alan D., MD

“…Background Polymorphisms in the serine protease inhibitor gene serine peptidase inhibitor Kazal type 5 (SPINK5) and the serine protease kallikrein-related…”
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Genetic Analysis of PSORS1 Distinguishes Guttate Psoriasis and Palmoplantar Pustulosis by Asumalahti, Kati, Ameen, Mahreen, Suomela, Sari, Hagforsen, Eva, Michaëlsson, Gerd, Evans, Julie, Munro, Margo, Veal, Colin, Allen, Michael, Leman, Joyce, David Burden, A., Kirby, Brian, Connolly, Maureen, Griffiths, Christopher E.M., Trembath, Richard C., Kere, Juha, Saarialho-Kere, Ulpu, Barker, Jonathan N.W.N.

“…The PSORS1 locus in the major histocompatibility complex region is the major genetic determinant for psoriasis vulgaris. Within the PSORS1 region reside at…”
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Differential Drug Survival of Biologic Therapies for the Treatment of Psoriasis: A Prospective Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR) by Warren, Richard B., Smith, Catherine H., Yiu, Zenas Z.N., Ashcroft, Darren M., Barker, Jonathan N.W.N., Burden, A. David, Lunt, Mark, McElhone, Kathleen, Ormerod, Anthony D., Owen, Caroline M., Reynolds, Nick J., Griffiths, Christopher E.M.

“…Drug survival reflects a drug’s effectiveness, safety, and tolerability. We assessed the drug survival of biologics used to treat psoriasis in a prospective…”
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Psoriasis 1: Pathogenesis and clinical features of psoriasis by Griffiths, Christopher E M, Jonathan N W N Barker

“…If a patient appears to have been cleared of psoriasis by systemic therapy, there is no reliable way to ascertain whether control is absolute other than…”
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γ-Secretase Mutations in Hidradenitis Suppurativa: New Insights into Disease Pathogenesis by Pink, Andrew E., Simpson, Michael A., Desai, Nemesha, Trembath, Richard C., Barker, Jonathan N.W.

“…Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition of unclear etiology. It may segregate as an autosomal dominant trait, and…”
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Are Janus kinase inhibitors an effective treatment for palmoplantar pustulosis? A critically appraised topic by Gleeson, David, Barker, Jonathan N W N, Capon, Francesca, Pink, Andrew E, Woolf, Richard T, Smith, Catherine H, Mahil, Satveer K

“…We carried out a critical appraisal of the literature to assess whether Janus kinase inhibitors are an effective treatment for palmoplantar pustulosis, a rare…”
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Acceptability of ‘as needed’ biologic therapy in psoriasis: insights from a multistakeholder mixed-methods study by Gleeson, David, Naveed, Maneeha, Moorhead, Lucy, McAteer, Helen, Sewell, Georgia, McGuire, Arlene, Weinman, John, Barker, Jonathan N W N, Norton, Sam, Chapman, Sarah C E, Smith, Catherine H, Mahil, Satveer K

“…Abstract Background Biologic therapies have led to increasing numbers of patients with psoriasis who have clear or nearly clear skin. It is current practice to…”
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Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci by Tsoi, Lam C., Spain, Sarah L., Ellinghaus, Eva, Stuart, Philip E., Capon, Francesca, Knight, Jo, Tejasvi, Trilokraj, Kang, Hyun M., Allen, Michael H., Lambert, Sylviane, Stoll, Stefan W., Weidinger, Stephan, Gudjonsson, Johann E., Koks, Sulev, Kingo, Külli, Esko, Tonu, Das, Sayantan, Metspalu, Andres, Weichenthal, Michael, Enerback, Charlotta, Krueger, Gerald G., Voorhees, John J., Chandran, Vinod, Rosen, Cheryl F., Rahman, Proton, Gladman, Dafna D., Reis, Andre, Nair, Rajan P., Franke, Andre, Barker, Jonathan N.W.N., Abecasis, Goncalo R., Trembath, Richard C., Elder, James T.

“…Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using…”
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