Search Results - "Jolly, Clemency"

Timing somatic events in the evolution of cancer by Jolly, Clemency, Van Loo, Peter

“…Cancer arises through the accumulation of somatic mutations over time. An understanding of the sequence of events during this process should allow both earlier…”
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Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast by Jeffares, Daniel C., Jolly, Clemency, Hoti, Mimoza, Speed, Doug, Shaw, Liam, Rallis, Charalampos, Balloux, Francois, Dessimoz, Christophe, Bähler, Jürg, Sedlazeck, Fritz J.

“…Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic…”
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Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture by Álvarez, Eva G., Demeulemeester, Jonas, Otero, Paula, Jolly, Clemency, García-Souto, Daniel, Pequeño-Valtierra, Ana, Zamora, Jorge, Tojo, Marta, Temes, Javier, Baez-Ortega, Adrian, Rodriguez-Martin, Bernardo, Oitaben, Ana, Bruzos, Alicia L., Martínez-Fernández, Mónica, Haase, Kerstin, Zumalave, Sonia, Abal, Rosanna, Rodríguez-Castro, Jorge, Rodriguez-Casanova, Aitor, Diaz-Lagares, Angel, Li, Yilong, Raine, Keiran M., Butler, Adam P., Otero, Iago, Ono, Atsushi, Aikata, Hiroshi, Chayama, Kazuaki, Ueno, Masaki, Hayami, Shinya, Yamaue, Hiroki, Maejima, Kazuhiro, Blanco, Miguel G., Forns, Xavier, Rivas, Carmen, Ruiz-Bañobre, Juan, Pérez-del-Pulgar, Sofía, Torres-Ruiz, Raúl, Rodriguez-Perales, Sandra, Garaigorta, Urtzi, Campbell, Peter J., Nakagawa, Hidewaki, Van Loo, Peter, Tubio, Jose M. C.

“…Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using…”
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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes by Dentro, Stefan C., Leshchiner, Ignaty, Haase, Kerstin, Wintersinger, Jeff, Deshwar, Amit G., Yu, Kaixian, Rubanova, Yulia, Macintyre, Geoff, Demeulemeester, Jonas, Vázquez-García, Ignacio, Kleinheinz, Kortine, Livitz, Dimitri G., Malikic, Salem, Donmez, Nilgun, Sengupta, Subhajit, Anur, Pavana, Jolly, Clemency, Rosebrock, Daniel, Schumacher, Steven E., Fittall, Matthew, Drews, Ruben M., Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Zhu, Hongtu, Adams, David J., McGranahan, Nicholas, Swanton, Charles, Getz, Gad, Boutros, Paul C., Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S. Cenk, Ji, Yuan, Peifer, Martin, Martincorena, Inigo, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Gerstung, Moritz, Spellman, Paul T., Wang, Wenyi, Wedge, David C., Dentro, Stefan C., Leshchiner, Ignaty, Gerstung, Moritz, Jolly, Clemency, Haase, Kerstin, Tarabichi, Maxime, Wintersinger, Jeff, Deshwar, Amit G., Yu, Kaixian, Rubanova, Yulia, Macintyre, Geoff, Demeulemeester, Jonas, Anur, Pavana, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D., Cao, Shaolong, Cmero, Marek, Cun, Yupeng, Dawson, Kevin J., Donmez, Nilgun, Drews, Ruben M., Eils, Roland, Fan, Yu, Fittall, Matthew, Getz, Gad, Ha, Gavin, Imielinski, Marcin, Ji, Yuan, Kleinheinz, Kortine, Lee, Juhee, Lee-Six, Henry, Livitz, Dimitri G., Malikic, Salem, Markowetz, Florian, Martincorena, Inigo, Mustonen, Ville, Oesper, Layla, Peifer, Martin, Peto, Myron, Raphael, Benjamin J., Rosebrock, Daniel, Salcedo, Adriana, Schumacher, Steven E., Sengupta, Subhajit, Shi, Ruian, Spiro, Oliver, Vázquez-García, Ignacio, Vembu, Shankar, Wheeler, David A., Yao, Xiaotong, Yuan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Van Loo, Peter

“…Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin, and…”
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The Timing of Key Events and Mutational Processes in Tumour Evolution by Jolly, Clemency

“…Cancer develops from normal tissues through the process of somatic evolution over time. The cells in our body continually acquire errors in their DNA through…”
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Neutral tumor evolution? by Tarabichi, Maxime, Martincorena, Iñigo, Gerstung, Moritz, Leroi, Armand M., Markowetz, Florian, Spellman, Paul T., Morris, Quaid D., Lingjærde, Ole Christian, Wedge, David C., Van Loo, Peter

“…According to this traditional model, the selective advantage is conferred by a small set of driver mutations, but as the subclones that bear them successively…”
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Author Correction: The evolutionary history of 2,658 cancers by Gerstung, Moritz, Jolly, Clemency, Leshchiner, Ignaty, Dentro, Stefan C., Gonzalez, Santiago, Rosebrock, Daniel, Mitchell, Thomas J., Rubanova, Yulia, Anur, Pavana, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, Vázquez-García, Ignacio, Haase, Kerstin, Jerman, Lara, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G., Cmero, Marek, Demeulemeester, Jonas, Schumacher, Steven, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C., Bowtell, David D., Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S. Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Van Loo, Peter

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Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction by Salcedo, Adriana, Tarabichi, Maxime, Buchanan, Alex, Espiritu, Shadrielle M G, Zhang, Hongjiu, Zhu, Kaiyi, Ou Yang, Tai-Hsien, Leshchiner, Ignaty, Anastassiou, Dimitris, Guan, Yuanfang, Jang, Gun Ho, Mootor, Mohammed F E, Haase, Kerstin, Deshwar, Amit G, Zou, William, Umar, Imaad, Dentro, Stefan, Wintersinger, Jeff A, Chiotti, Kami, Demeulemeester, Jonas, Jolly, Clemency, Sycza, Lesia, Ko, Minjeong, Wedge, David C, Morris, Quaid D, Ellrott, Kyle, Van Loo, Peter, Boutros, Paul C

“…Subclonal reconstruction algorithms use bulk DNA sequencing data to quantify parameters of tumor evolution, allowing an assessment of how cancers initiate,…”
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Abstract 3000: Pervasive intra-tumour heterogeneity and subclonal selection across cancer types by Dentro, Stefan, Leshchiner, Ignaty, Haase, Kerstin, Wintersinger, Jeff, Deshwar, Amit, Tarabichi, Maxime, Rubanova, Yulia, Yu, Kaixian, Vázquez García, Ignacio, Macintyre, Geoff, Kleinheinz, Kortine, Livitz, Dimitri, Malikic, Salem, Donmez, Nilgun, Sengupta, Subhajit, Ji, Yuan, Demeulemeester, Jonas, Anur, Pavana, Jolly, Clemency, Cmero, Marek, Rosebrock, Daniel, Schumacher, Steve, Fan, Yu, Fittall, Matthew, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Zhu, Hongtu, Adams, David, Getz, Gad, Boutros, Paul, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, Cenk, Peifer, Martin, Martincorena, Inigo, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Gerstung, Moritz, Wang, Wenyi, Spellman, Paul, Morris, Quaid, Wedge, David, Loo, Peter Van

“…Abstract We have characterised intra-tumour heterogeneity (ITH) across 2,778 whole genome sequences of tumours in the International Cancer Genome Consortium…”
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Abstract 218: The evolutionary history of 2,658 cancers by Jolly, Clemency, Gerstung, Moritz, Leshchiner, Ignaty, Dentro, Stefan C., Gonzalez, Santiago, Mitchell, Thomas J., Rubanova, Yulia, Anur, Pavana, Rosebrock, Daniel, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, Vásquez-García, Ignacio, Haase, Kerstin, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G., Cmero, Mark, Demeulemeester, Jonas, Schumacher, Steve, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C., Bowtell, David D., Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Juan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Loo, Peter Van

“…Abstract Cancer develops through a continuous process of somatic evolution. Whole genome sequencing provides a snapshot of the tumor genome at the point of…”
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