Search Results - "Jolly, Carol E"

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury by Ball, Amy Louise, Jolly, Carol E, Lennon, Mark G, Lyon, Jonathan J, Alfirevic, Ana, Chadwick, Amy E

“…Evidence supports an important link between mitochondrial DNA (mtDNA) variation and adverse drug reactions such as idiosyncratic drug-induced liver injury…”
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Greater mechanistic understanding of the cutaneous pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis can shed light on novel therapeutic strategies: a comprehensive review by Ogiji, Emeka D, Aboheimed, Nourah, Ross, Kehinde, Voller, Calum, Siner, Ryan, Jensen, Rebecca L, Jolly, Carol E, Carr, Daniel F

“…Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by widespread epithelial…”
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The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity by Kamalian, Laleh, Douglas, Oisin, Jolly, Carol E., Snoeys, Jan, Simic, Damir, Monshouwer, Mario, Williams, Dominic P., Kevin Park, B., Chadwick, Amy E.

“…The importance of mitochondrial toxicity in drug-induced liver injury is well established. The bioenergetic phenotype of the HepaRG cell line was defined in…”
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The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine by Jolly, Carol E., Douglas, Oisin, Kamalian, Laleh, Jenkins, Rosalind E., Beckett, Alison J., Penman, Sophie L., Williams, Dominic P., Monshouwer, Mario, Simic, Damir, Snoeys, Jan, Park, B. Kevin, Chadwick, Amy E.

“…During its clinical development fialuridine caused liver toxicity and the death of five patients. This case remains relevant due to the continued development…”
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Selective induction of apoptosis by leptomycin B in keratinocytes expressing HPV oncogenes by Gray, Lindsey J., Bjelogrlic, Predrag, Appleyard, Virginia C.L., Thompson, Alastair M., Jolly, Carol E., Lain, Sonia, Herrington, C. Simon

“…Human papillomavirus (HPV) infection is strongly associated with the development of anogenital neoplasia, particularly cervical cancer. It has been estimated…”
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Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome by JOLLY, Carol E, GRAY, Lindsey J, PARISH, Joanna L, LAIN, Sonia, HERRINGTON, C. Simon

“…Cervical cancer is a major cause of death in women worldwide and is strongly associated with human papillomavirus (HPV) infection. Integration of HPV is…”
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The effects of leptomycin b on hpv-infected cells by Jolly, Carol E

“…Cervical cancer is a major cause of death in women and is strongly associated with infection by human papillomavirus (HPV). Integration of HPV is thought to…”
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Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity by Kamalian, Laleh, Douglas, Oisin, Jolly, Carol E, Snoeys, Jan, Simic, Damir, Monshouwer, Mario, Williams, Dominic P, Park, B Kevin, Chadwick, Amy E

“…Using galactose instead of glucose in the culture medium of hepatoma cell lines, such as HepG2 cells, has been utilized for a decade to unmask the…”
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