Search Results - "Jolidon, S"
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1
4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum
Published in Antimicrobial Agents and Chemotherapy (01-08-1996)“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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2
Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site
Published in Proceedings of the National Academy of Sciences - PNAS (06-11-2001)“…We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and recombinant metabotropic…”
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3
9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers
Published in Bioorganic & medicinal chemistry letters (15-10-2005)“…Small molecule mGluR1 enhancers based on the lead compound (9H-xanthene-9-carbonyl)-carbamic acid butyl ester derived from random-screening hit…”
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4
Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agents
Published in Biochemical Society transactions (01-02-1990)Get more information
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5
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability
Published in Bioorganic & medicinal chemistry letters (15-08-2006)“…A novel class of 2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1 inhibitors. In general, the…”
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6
Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors
Published in Journal of medicinal chemistry (17-07-2003)“…New orally active non-terpenoic inhibitors of human 2,3-oxidosqualene cyclase (hOSC) are reported. The starting point for the optimization process was a set of…”
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7
4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters
Published in Bioorganic & medicinal chemistry letters (15-08-2006)“…A novel class of 4-substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1…”
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8
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors
Published in Bioorganic & medicinal chemistry letters (15-08-2006)“…A novel class of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1…”
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9
A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance
Published in Journal of molecular biology (14-02-1997)“…A single amino acid substitution, Phe98 to Tyr98, in dihydrofolate reductase (DHFR) is the molecular origin of trimethoprim (TMP) resistance in Staphylococcus…”
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10
The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae
Published in Journal of molecular biology (26-03-1999)“…The gene encoding the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase of Haemophilus influenzae has been cloned and expressed in Escherichia coli. A…”
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