Search Results - "Joles, J A"

Pregnancy as a critical window for blood pressure regulation in mother and child: programming and reprogramming by Paauw, N. D., Rijn, B. B., Lely, A. T., Joles, J. A.

“…Pregnancy is a critical time for long‐term blood pressure regulation in both mother and child. Pregnancies complicated by placental insufficiency, resulting in…”
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Acute renal haemodynamic effects of glucagon-like peptide-1 receptor agonist exenatide in healthy overweight men by Muskiet, M. H. A., Tonneijck, L., Smits, M. M., Kramer, M. H. H., Diamant, M., Joles, J. A., van Raalte, D. H.

“…Aims To determine the acute effect of glucagon‐like peptide‐1 (GLP‐1) receptor agonist exenatide and the involvement of nitric oxide (NO) on renal…”
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GFR estimation is complicated by a high incidence of non-steady-state serum creatinine concentrations at the emergency department by Niemantsverdriet, M S A, Pieters, T T, Hoefer, I E, Verhaar, M C, Joles, J A, van Solinge, W W, Tiel Groenestege, W M, Haitjema, S, Rookmaaker, M B

“…Acquiring a reliable estimate of glomerular filtration rate (eGFR) at the emergency department (ED) is important for clinical management and for dosing renally…”
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H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction by Paauw, N D, Lely, A T, Joles, J A, Franx, A, Nikkels, P G, Mokry, M, van Rijn, B B

“…Posttranslational modification of histone tails such as histone 3 lysine 27 acetylation (H3K27ac) is tightly coupled to epigenetic regulation of gene…”
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Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing by Schumacher, A., Rookmaaker, M. B., Joles, J. A., Kramann, R., Nguyen, T. Q., van Griensven, M., LaPointe, V. L. S.

“…The kidney is among the most complex organs in terms of the variety of cell types. The cellular complexity of human kidneys is not fully unraveled and this…”
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Increased susceptibility to hypertensive renal disease in streptozotocin-treated diabetic rats is not modulated by salt intake by Sima, C. A., Koeners, M. P., Joles, J. A., Braam, B., Magil, A. B., Cupples, W. A.

“…Aims/hypothesis In early type 1 diabetes mellitus, renal salt handling is dysregulated, so that the glomerular filtration rate becomes inversely proportional…”
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Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells by Ishola, D.A., Post, J.A., van Timmeren, M.M., Bakker, S.J.L., Goldschmeding, R., Koomans, H.A., Braam, B., Joles, J.A.

“…Albumin induces oxidative stress and cytokine production in proximal tubular cells (PTECs). Albumin-bound fatty acids (FAs) enhance tubulopathic effects of…”
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Nitric oxide, superoxide and renal blood flow autoregulation in SHR after perinatal L-arginine and antioxidants by Koeners, M.P, Racasan, S, Koomans, H.A, Joles, J.A, Braam, B

“…Nitric oxide (NO) and superoxide are considered to be regulatory in renal blood flow (RBF) autoregulation, and hence may contribute to development of…”
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Left ventricular assist devices: a kidney’s perspective by Tromp, T. R., de Jonge, N., Joles, J. A.

“…The left ventricular assist device (LVAD) has become an established treatment option for patients with refractory heart failure. Many of these patients…”
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Exenatide twice-daily does not affect renal function or albuminuria compared to titrated insulin glargine in patients with type 2 diabetes mellitus: A post-hoc analysis of a 52-week randomised trial by Muskiet, M.H.A., Bunck, M.C., Heine, R.J., Cornér, A., Yki-Järvinen, H., Eliasson, B., Joles, J.A., Diamant, M., Tonneijck, L., van Raalte, D.H.

“…To compare the effects of long-term treatment with the GLP-1RA exenatide twice-daily versus titrated insulin glargine (iGlar) on renal function and albuminuria…”
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Hypoalbuminemia causes high blood viscosity by increasing red cell lysophosphatidylcholine by Joles, Jaap A., Willekes-Koolschijn, Nel, Koomans, Hein A.

“…Hypoalbuminemia causes high blood viscosity by increasing red cell lysophosphatidylcholine. Albumin deficiency is accompanied by a reduction in red cell…”
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ACE inhibition and glomerular repair: restructuring or regeneration? by Joles, J.A., Braam, B., Verhaar, M.C.

“…In this issue of Kidney International, Andrea Remuzzi et al. convincingly demonstrate glomerular repair in spontaneous renal disease by ACE inhibition. These…”
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Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation by Oosterhuis, N. R., Bongartz, L. G., Verhaar, M. C., Cheng, C., Xu, Y. J., Koppen, A., Cramer, M. J., Goldschmeding, R., Gaillard, C. A., Doevendans, P. A., Braam, B., Joles, J. A.

“…Aim Multiple interacting pathways contribute to progression of renal and cardiac damage in chronic kidney disease followed by chronic heart failure…”
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Conversion to mycophenolate mofetil in conjunction with stepwise withdrawal of cyclosporine in stable renal transplant recipients by SCHRAMA, Y. C, JOLES, J. A, VAN TOL, A, BOER, P, KOOMANS, H. A, HENE, R. J

“…Mycophenolate mofetil (MMF) is now part of standard immunosuppression in the first phase after renal transplantation. A relevant question is if it can replace…”
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Mixed matrix membranes: a new asset for blood purification therapies by Tijink, M S L, Kooman, J, Wester, M, Sun, J, Saiful, S, Joles, J A, Borneman, Z, Wessling, M, Stamatialis, D F

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Differential effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on the development of myopathy in young rats by REIJNEVELD, J. C, KOOT, R. W, BREDMAN, J. J, JOLES, J. A, BÄR, P. R

“…HMG-CoA reductase inhibitors (statins), cholesterol-lowering drugs that have not been approved for use in children and adolescents, may cause myopathy as a…”
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Estrogen induces glomerulosclerosis in analbuminemic rats by Joles, Jaap A., van Goor, Harry, Koomans, Hein A.

“…Estrogen induces glomerulosclerosis in analbuminemic rats. Progression of chronic renal disease is usually more rapid in males, both in humans and in…”
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Transient nitric oxide reduction induces permanent cardiac systolic dysfunction and worsens kidney damage in rats with chronic kidney disease by Bongartz, L G, Braam, B, Verhaar, M C, Cramer, M J, Goldschmeding, R, Gaillard, C A, Doevendans, P A, Joles, J A

“…Left ventricular systolic dysfunction (LVSD) in patients with chronic kidney disease (CKD) is associated with poorer prognosis. Because patients with CKD often…”
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Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis by Gerritsen, K. G. F., Bovenschen, N., Nguyen, T. Q., Sprengers, D., Koeners, M. P., van Koppen, A. N., Joles, J. A., Goldschmeding, R., Kok, R. J.

“…CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is…”
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Volume regulation in children with early relapse of minimal-change nephrosis with or without hypovolaemic symptoms by Vande Walle, J G, Donckerwolcke, R A, van Isselt, J W, Derkx, F H, Joles, J A, Koomans, H A

“…The cause of sodium retention in nephrotic syndrome is unclear. Hypovolaemia has traditionally been labelled as the cause but there is evidence in adults of a…”
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