Search Results - "Joksimovic, Srdjan M."

Early exposure to general anesthesia impairs social and emotional development in rats by Diana, Paolo, Joksimovic, Srdjan M., Faisant, Azra, Jevtovic-Todorovic, Vesna

“…Several animal and emerging human studies suggest an association between an early exposure to general anesthesia (GA) and long-lasting problems with complex…”
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Neonatal Isoflurane Does Not Affect Sleep Architecture and Minimally Alters Neuronal Beta Oscillations in Adolescent Rats by Manzella, Francesca M, Gulvezan, Bethany F, Maksimovic, Stefan, Useinovic, Nemanja, Raol, Yogendra H, Joksimovic, Srdjan M, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…General anesthetics are neurotoxic to the developing rodent and primate brains leading to neurocognitive and socio-affective impairment later in life. In…”
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Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats by Manzella, Francesca M, Joksimovic, Srdjan M, Orfila, James E, Fine, Brier R, Dietz, Robert M, Sampath, Dayalan, Fiedler, Hanna K, Tesic, Vesna, Atluri, Navya, Raol, Yogendra H, Jevtovic-Todorovic, Vesna, Herson, Paco S, Todorovic, Slobodan M

“…Exposure to sedative/hypnotic and anesthetic drugs, such as ketamine, during the critical period of synaptogenesis, causes profound neurotoxicity in the…”
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Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels by Tat, Quy L, Joksimovic, Srdjan M, Krishnan, Kathiresan, Covey, Douglas F, Todorovic, Slobodan M, Jevtovic-Todorovic, Vesna

“…Preemptive management of post-incisional pain remains challenging. Here, we examined the role of preemptive use of neuroactive steroids with activity on…”
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Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA A currents, but are not neurotoxic to the developing rat brain by Tesic, Vesna, Joksimovic, Srdjan M, Quillinan, Nidia, Krishnan, Kathiresan, Covey, Douglas F, Todorovic, Slobodan M, Jevtovic-Todorovic, Vesna

“…The most currently used general anaesthetics are potent potentiators of γ-aminobutyric acid A (GABA ) receptors and are invariably neurotoxic during the early…”
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Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats by Joksimovic, Srdjan M, Sampath, Dayalan, Krishnan, Kathiresan, Covey, Douglas F, Jevtovic-Todorovic, Vesna, Raol, Yogendra H, Todorovic, Slobodan M

“…We recently showed that a neurosteroid analogue, (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rats. The aim of the present…”
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CaV3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum by Joksimovic, Srdjan M., Ghodsi, Seyed Mohammadreza, Heinsbroek, Jasper A., Orfila, James E., Busquet, Nicolas, Tesic, Vesna, Valdez, Robert, Fine-Raquet, Brier, Jevtovic-Todorovic, Vesna, Raol, Yogendra H., Herson, Paco S., Todorovic, Slobodan M.

“…The dorsal subiculum (dSub) is one of the key structures responsible for the formation of hippocampal memory traces but the contribution of individual ionic…”
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The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development by Joksimovic, Srdjan M., DiGruccio, Michael R., Boscolo, Annalisa, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.

“…A large number of preclinical studies have established that general anesthetics (GAs) may cause neurodevelopmental toxicity in rodents and nonhuman primates,…”
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Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain by Joksimovic, Sonja Lj, Joksimovic, Srdjan M., Manzella, Francesca M., Asnake, Betelehem, Orestes, Peihan, Raol, Yogendra H., Krishnan, Kathiresan, Covey, Douglas F., Jevtovic‐Todorovic, Vesna, Todorovic, Slobodan M.

“…Background and Purpose Neuroactive steroid (3β,5β,17β)‐3‐hydroxyandrostane‐17‐carbonitrile (3β‐OH) is a novel hypnotic and voltage‐dependent blocker of T‐type…”
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Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum by Fine-Raquet, Brier, Manzella, Francesca M, Joksimovic, Srdjan M, Dietz, Robert M, Orfila, James E, Sampath, Dayalan, Tesic, Vesna, Atluri, Navya, Covey, Douglas F, Raol, Yogendra H, Jevtovic-Todorovic, Vesna, Herson, Paco S, Todorovic, Slobodan M

“…Preclinical studies have established that neonatal exposure to contemporary sedative/hypnotic drugs causes neurotoxicity in the developing rodent and primate…”
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Ca V 3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons by Tracy, Matthew E, Tesic, Vesna, Stamenic, Tamara Timic, Joksimovic, Srdjan M, Busquet, Nicolas, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…Recent data have implicated voltage-gated calcium channels in the regulation of the excitability of neurons within the mesolimbic reward system. While the…”
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The role of KCC2 in hyperexcitability of the neonatal brain by Raol, Yogendra H., Joksimovic, Srdjan M., Sampath, Dayalan, Matter, Brock A., Lam, Philip M., Kompella, Uday B., Todorovic, Slobodan M., González, Marco I.

“…•The functional role of KCC2 in preventing overexcitation in neonatal brain is not clear.•We show that reducing KCC2 activity exacerbates neonatal brain…”
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The role of T‐type calcium channels in the subiculum: to burst or not to burst? by Joksimovic, Srdjan M., Eggan, Pierce, Izumi, Yukitoshi, Joksimovic, Sonja Lj, Tesic, Vesna, Dietz, Robert M., Orfila, James E., DiGruccio, Michael R., Herson, Paco S., Jevtovic‐Todorovic, Vesna, Zorumski, Charles F., Todorovic, Slobodan M.

“…Key points Pharmacological, molecular and genetic data indicate a prominent role of low‐voltage‐activated T‐type calcium channels (T‐channels) in the firing…”
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Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus by Joksimovic, Srdjan M., Osuru, Hari Prasad, Oklopcic, Azra, Beenhakker, Mark P., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.

“…Recent evidence strongly supports the idea that common general anesthetics (GAs) such as isoflurane (Iso) and nitrous oxide (N 2 O; laughing gas), as well as…”
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CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons by Tracy, Matthew E., Tesic, Vesna, Stamenic, Tamara Timic, Joksimovic, Srdjan M., Busquet, Nicolas, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.

“…Recent data have implicated voltage-gated calcium channels in the regulation of the excitability of neurons within the mesolimbic reward system. While the…”
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Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum by Joksimovic, Srdjan M, Izumi, Yukitoshi, Joksimovic, Sonja Lj, Tesic, Vesna, Krishnan, Kathiresan, Asnake, Betelehem, Jevtovic-Todorovic, Vesna, Covey, Douglas F, Zorumski, Charles F, Todorovic, Slobodan M

“…Hypnotics and general anaesthetics impair memory by altering hippocampal synaptic plasticity. We recently reported on a neurosteroid analogue with potent…”
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Selective inhibition of Ca V 3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain by Joksimovic, Sonja L, Joksimovic, Srdjan M, Tesic, Vesna, García-Caballero, Agustin, Feseha, Simon, Zamponi, Gerald W, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…Pain-sensing sensory neurons of the dorsal root ganglion (DRG) can become sensitized or hyperexcitable in response to surgically induced peripheral tissue…”
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Ca V 3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum by Joksimovic, Srdjan M, Ghodsi, Seyed Mohammadreza, Heinsbroek, Jasper A, Orfila, James E, Busquet, Nicolas, Tesic, Vesna, Valdez, Robert, Fine-Raquet, Brier, Jevtovic-Todorovic, Vesna, Raol, Yogendra H, Herson, Paco S, Todorovic, Slobodan M

“…The dorsal subiculum (dSub) is one of the key structures responsible for the formation of hippocampal memory traces but the contribution of individual ionic…”
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