Search Results - "Johnstone, Timothy G"

Upstream ORFs are prevalent translational repressors in vertebrates by Johnstone, Timothy G, Bazzini, Ariel A, Giraldez, Antonio J

“…Regulation of gene expression is fundamental in establishing cellular diversity and a target of natural selection. Untranslated mRNA regions (UTRs) are key…”
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The C. elegans SNAPc Component SNPC-4 Coats piRNA Domains and Is Globally Required for piRNA Abundance by Kasper, Dionna M., Wang, Guilin, Gardner, Kathryn E., Johnstone, Timothy G., Reinke, Valerie

“…The Piwi/Piwi-interacting RNA (piRNA) pathway protects the germline from the activity of foreign sequences such as transposons. Remarkably, tens of thousands…”
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B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma by Ohm-Laursen, Line, Meng, Hailong, Hoehn, Kenneth B, Nouri, Nima, Jiang, Yue, Clouser, Chris, Johnstone, Timothy G, Hause, Ron, Sandhar, Balraj S, Upton, Nadine E G, Chevretton, Elfy B, Lakhani, Raj, Corrigan, Chris J, Kleinstein, Steven H, Gould, Hannah J

“…In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis…”
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Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition by Bazzini, Ariel A, del Viso, Florencia, Moreno-Mateos, Miguel A, Johnstone, Timothy G, Vejnar, Charles E, Qin, Yidan, Yao, Jun, Khokha, Mustafa K, Giraldez, Antonio J

“…Cellular transitions require dramatic changes in gene expression that are supported by regulated mRNA decay and new transcription. The maternal‐to‐zygotic…”
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Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation by Bazzini, Ariel A, Johnstone, Timothy G, Christiano, Romain, Mackowiak, Sebastian D, Obermayer, Benedikt, Fleming, Elizabeth S, Vejnar, Charles E, Lee, Miler T, Rajewsky, Nikolaus, Walther, Tobias C, Giraldez, Antonio J

“…Identification of the coding elements in the genome is a fundamental step to understanding the building blocks of living systems. Short peptides (< 100 aa)…”
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Anti-B-cell Maturation Antigen Chimeric Antigen Receptor T cell Function against Multiple Myeloma Is Enhanced in the Presence of Lenalidomide by Works, Melissa, Soni, Neha, Hauskins, Collin, Sierra, Catherine, Baturevych, Alex, Jones, Jon C, Curtis, Wendy, Carlson, Patrick, Johnstone, Timothy G, Kugler, David, Hause, Ronald J, Jiang, Yue, Wimberly, Lindsey, Clouser, Christopher R, Jessup, Heidi K, Sather, Blythe, Salmon, Ruth A, Ports, Michael O

“…Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells have shown promising clinical responses in patients with relapsed/refractory…”
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Antitumor Potency of an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, Lisocabtagene Maraleucel in Combination With Ibrutinib or Acalabrutinib by Qin, Jim S., Johnstone, Timothy G., Baturevych, Alex, Hause, Ronald J., Ragan, Seamus P., Clouser, Christopher R., Jones, Jon C., Ponce, Rafael, Krejsa, Cecile M., Salmon, Ruth A., Ports, Michael O.

“…Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment for patients with CD19+ B-cell malignancies. Combination strategies that improve CAR…”
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Upstream ORF s are prevalent translational repressors in vertebrates by Johnstone, Timothy G, Bazzini, Ariel A, Giraldez, Antonio J

“…Abstract Regulation of gene expression is fundamental in establishing cellular diversity and a target of natural selection. Untranslated mRNA regions ( UTR s)…”
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Abstract 1541: Directed, unbiased mapping of lentiviral integrations with next generation sequencing in CAR-T cells by Johnstone, Timothy G., Chari, Rajagopal, Koppstein, David, Hause, Ronald J., Ponce, Rafael, Briggs, Adrian W., Vigneault, Francois

“…Abstract During manufacturing of an exemplary CD19-directed CAR-T cell product, patient T cells were transduced with a viral vector encoding the CD19-directed,…”
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Lisocabtagene Maraleucel (liso-cel) Manufacturing Process Control and Robustness across CD19+ Hematological Malignancies by Teoh, Jeffrey, Johnstone, Timothy G., Christin, Brian, Yost, Rachel, Haig, Neil A., Mallaney, Mary, Radhakrishnan, Aditya, Gillenwater, Heidi H., Albertson, Tina, Guptill, Paul, Brown, Lauren F., Ramsborg, Christopher G., Hause, Ronald J., Larson, Ryan P.

“…Background Lisocabtagene maraleucel (liso-cel) is an investigational, CD19-directed, genetically modified, autologous cellular immunotherapy administered as a…”
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