Search Results - "Johnston, Victor K"

Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine by Salvatore, Christopher A, Hershey, James C, Corcoran, Halea A, Fay, John F, Johnston, Victor K, Moore, Eric L, Mosser, Scott D, Burgey, Christopher S, Paone, Daniel V, Shaw, Anthony W, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M, Koblan, Kenneth S, Kane, Stefanie A

“…Calcitonin gene-related peptide (CGRP) is a potent neuropeptide that plays a key role in the pathophysiology of migraine headache. CGRP levels in the cranial…”
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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974) by Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M

“…Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Herein we describe optimization of CGRP receptor antagonists based…”
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Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase by Dhanak, Dashyant, Duffy, Kevin J., Johnston, Victor K., Lin-Goerke, Juili, Darcy, Michael, Shaw, Antony N., Gu, Baohua, Silverman, Carol, Gates, Adam T., Nonnemacher, Michael R., Earnshaw, David L., Casper, David J., Kaura, Arun, Baker, Audrey, Greenwood, Cathy, Gutshall, Lester L., Maley, Derrick, DelVecchio, Alfred, Macarron, Ricardo, Hofmann, Glenn A., Alnoah, Zaid, Cheng, Hung-Yuan, Chan, George, Khandekar, Sanjay, Keenan, Richard M., Sarisky, Robert T.

“…The hepatitis C virus (HCV) NS5B protein encodes an RNA-dependent RNA polymerase (RdRp), the primary catalytic enzyme of the HCV replicase complex. We…”
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Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor by NGUYEN, Tammy T, GATES, Adam T, GUTSHALL, Lester L, JOHNSTON, Victor K, BAOHUA GU, DUFFY, Kevin J, SARISKY, Robert T

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Arresting Initiation of Hepatitis C Virus RNA Synthesis Using Heterocyclic Derivatives by Gu, Baohua, Johnston, Victor K., Gutshall, Lester L., Nguyen, Tammy T., Gontarek, Richard R., Darcy, Michael G., Tedesco, Rosanna, Dhanak, Dashyant, Duffy, Kevin J., Kao, C. Cheng, Sarisky, Robert T.

“…The hepatitis C virus (HCV) NS5B protein encodes an RNA-dependent RNA polymerase (RdRp), the primary catalytic enzyme of the HCV replicase complex. Recently,…”
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An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase by Evans, Karen A., Chai, Deping, Graybill, Todd L., Burton, George, Sarisky, Robert T., Lin-Goerke, Juili, Johnston, Victor K., Rivero, Ralph A.

“…Solid-phase synthesis and SAR are described for a series of benzothiadiazine-substituted tetramic acid inhibitors of the hepatitis C virus RNA-dependent RNA…”
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3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase by Tedesco, Rosanna, Shaw, Antony N, Bambal, Ramesh, Chai, Deping, Concha, Nestor O, Darcy, Michael G, Dhanak, Dashyant, Fitch, Duke M, Gates, Adam, Gerhardt, Warren G, Halegoua, Dina L, Han, Chao, Hofmann, Glenn A, Johnston, Victor K, Kaura, Arun C, Liu, Nannan, Keenan, Richard M, Lin-Goerke, Juili, Sarisky, Robert T, Wiggall, Kenneth J, Zimmerman, Michael N, Duffy, Kevin J

“…Recently, we disclosed a new class of HCV polymerase inhibitors discovered through high-throughput screening (HTS) of the GlaxoSmithKline proprietary compound…”
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Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase by Shaw, Antony N., Tedesco, Rosanna, Bambal, Ramesh, Chai, Deping, Concha, Nestor O., Darcy, Michael G., Dhanak, Dashyant, Duffy, Kevin J., Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Liu, Nannan, Sarisky, Robert T., Wiggall, Kenneth J., Zimmerman, Michael N.

“…The optimisation of benzothiadiazine HCV polymerase inhibitors 2 with improved potency is reported. The synthesis and optimisation of HCV NS5B polymerase…”
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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors by Tedesco, Rosanna, Chai, Deping, Darcy, Michael G., Dhanak, Dashyant, Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Sarisky, Robert T., Shaw, Antony N., Valko, Klara L., Wiggall, Kenneth J., Zimmerman, Michael N., Duffy, Kevin J.

“…Modification of the benzo rings of 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones into heteroaromatic systems was investigated to…”
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The discovery of highly potent CGRP receptor antagonists by Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Bruno, Joseph G., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Salvatore, Christopher A., Theberge, Cory R., Blair Zartman, C., Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.

“…Rational modification of a previously identified spirohydantoin lead structure has identified a series of potent spiroazaoxindole CGRP receptor antagonists…”
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Potent benzimidazolone-based CGRP receptor antagonists by THEBERGE, Cory R, BEDNAR, Rodney A, WILLIAMS, Theresa M, ZARTMAN, C. Blair, ZHANG, Xu-Fang, GRAHAM, Samuel L, VACCA, Joseph P, BELL, Ian M, CORCORAN, Halea A, FAY, John F, HERSHEY, James C, JOHNSTON, Victor K, KANE, Stefanie A, MOSSER, Scott, SALVATORE, Christopher A

“…The previously disclosed spirohydantoin-based CGRP receptor antagonists were optimized for potency through modification of the benzimidazolone substituents…”
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The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists by Bell, Ian M., Bednar, Rodney A., Corcoran, Halea A., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Hershey, James C., Miller-Stein, Cynthia M., Moore, Eric L., Mosser, Scott D., Roller, Shane A., Salvatore, Christopher A., Theberge, Cory R., Wong, Bradley K., Blair Zartman, C., Kane, Stefanie A., Williams, Theresa M., Graham, Samuel L., Vacca, Joseph P.

“…A series of tricyclic CGRP receptor antagonists was optimized in order to improve oral bioavailability. Attenuation of polar surface area and incorporation of…”
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Kinetic profile of a heterocyclic HCV replicon RNA synthesis inhibitor by Johnston, Victor K, Maley, Derrick, Gagnon, Robert C, Grassmann, Claus W, Behrens, Sven-Erik, Sarisky, Robert T

“…Recently, a benzo-1,2,4-thiadiazine was shown to be a potent, specific inhibitor of the hepatitis C virus (HCV) RNA polymerase [J. Biol. Chem. 277 (2002)…”
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Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase by Ranjith-Kumar, C.T, Santos, Jan Lee, Gutshall, Lester L, Johnston, Victor K, Lin-Goerke, Juili, Kim, Min-Ju, Porter, David J, Maley, Derrick, Greenwood, Cathy, Earnshaw, David L, Baker, Audrey, Gu, Baohua, Silverman, Carol, Sarisky, Robert T, Kao, Cheng

“…The GB virus-B (GBV-B) nonstructural protein 5B (NS5B) encodes an RNA-dependent RNA polymerase (RdRp) with greater than 50% sequence similarity to the…”
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Intracellular hepatitis C virus RNA-dependent RNA polymerase activity by DeMarini, Douglas J, Johnston, Victor K, Konduri, Madhavi, Gutshall, Lester L, Sarisky, Robert T

“…Hepatitis C virus (HCV) infection represents a significant health concern in over 170 million individuals worldwide. Recently, Huh7 cell-based hepatitis C…”
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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzo-thiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors by TEDESCO, Rosanna, DEPING CHAI, SHAW, Antony N, VALKO, Klara L, WIGGALL, Kenneth J, ZIMMERMAN, Michael N, DUFFY, Kevin J, DARCY, Michael G, DHANAK, Dashyant, FITCH, Duke M, GATES, Adam, JOHNSTON, Victor K, KEENAN, Richard M, LIN-GOERKE, Juili, SARISKY, Robert T

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