Search Results - "Johnston, Randal"

Reovirus combined with a STING agonist enhances anti-tumor immunity in a mouse model of colorectal cancer by Sugimura, Naomi, Kubota, Eiji, Mori, Yoshinori, Aoyama, Mineyoshi, Tanaka, Mamoru, Shimura, Takaya, Tanida, Satoshi, Johnston, Randal N., Kataoka, Hiromi

“…Reovirus, a naturally occurring oncolytic virus, initiates the lysis of tumor cells while simultaneously releasing tumor antigens or proapoptotic cytokines in…”
Get full text

Going (Reo)Viral: Factors Promoting Successful Reoviral Oncolytic Infection by Bourhill, Tarryn, Mori, Yoshinori, Rancourt, Derrick E, Shmulevitz, Maya, Johnston, Randal N

“…Oncolytic viruses show intriguing potential as cancer therapeutic agents. These viruses are capable of selectively targeting and killing cancerous cells while…”
Get full text

Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants by Mohamed, Adil, Johnston, Randal N, Shmulevitz, Maya

“…Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly;…”
Get full text

Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9 by Liu, Huidi, Zeng, Zheng, Wang, Siwen, Li, Ting, Mastriani, Emilio, Li, Qing-Hai, Bao, Hong-Xia, Zhou, Yu-Jie, Wang, Xiaoyu, Liu, Yongfang, Liu, Wei, Hu, Sijing, Gao, Shan, Yu, Miao, Qi, Yingying, Shen, Zhihang, Wang, Hongyue, Gao, Tingting, Dong, Lingqin, Johnston, Randal N., Liu, Shu-Lin

“…Ovarian cancer is the third most common cancer in the female reproductive organs and epithelial ovarian cancer has the highest lethality of all gynecological…”
Get full text

African Swine Fever Virus NP868R Capping Enzyme Promotes Reovirus Rescue during Reverse Genetics by Promoting Reovirus Protein Expression, Virion Assembly, and RNA Incorporation into Infectious Virions by Eaton, Heather E, Kobayashi, Takeshi, Dermody, Terence S, Johnston, Randal N, Jais, Philippe H, Shmulevitz, Maya

“…Reoviruses, like many eukaryotic viruses, contain an inverted 7-methylguanosine (m7G) cap linked to the 5' nucleotide of mRNA. The traditional functions of…”
Get full text

Genomic comparison between Salmonella Gallinarum and Pullorum: differential pseudogene formation under common host restriction by Feng, Ye, Johnston, Randal N, Liu, Gui-Rong, Liu, Shu-Lin

“…Salmonella serovars Enteritidis and Gallinarum are closely related, but their host ranges are very different: the former is host-promiscuous and the latter can…”
Get full text

Modulation of Reoviral Cytolysis (II): Cellular Stemness by Bourhill, Tarryn, Rohani, Leili, Kumar, Mehul, Bose, Pinaki, Rancourt, Derrick, Johnston, Randal N

“…Oncolytic viruses (OVs) are an emerging cancer therapeutic that are intended to act by selectively targeting and lysing cancerous cells and by stimulating…”
Get full text

The Oncogenic Functions of Insulin-like Growth Factor 2 mRNA-Binding Protein 3 in Human Carcinomas by Wang, Peng-Fei, Wang, Xiaoyu, Liu, Min, Zeng, Zheng, Lin, Caiji, Xu, Wenwen, Ma, Wenqing, Wang, Jiali, Xiang, Qian, Johnston, Randal N, Liu, Huidi, Liu, Shu-Lin

“…IGF2BP3 (also known as IMP3, KOC), a member of the insulin-like growth factor mRNA-binding protein family (IMPs), has been a research target in recent studies…”
Get more information

Modulation of Reoviral Cytolysis (I): Combination Therapeutics by Mori, Yoshinori, Nishikawa, Sandra G, Fratiloiu, Andreea R, Tsutsui, Mio, Kataoka, Hiromi, Joh, Takashi, Johnston, Randal N

“…Patients with stage IV gastric cancer suffer from dismal outcomes, a challenge especially in many Asian populations and for which new therapeutic options are…”
Get full text

Overexpression of IGF2BP3 as a Potential Oncogene in Ovarian Clear Cell Carcinoma by Liu, Huidi, Zeng, Zheng, Afsharpad, Mitra, Lin, Caiji, Wang, Siwen, Yang, Hao, Liu, Shuhong, Kelemen, Linda E, Xu, Wenwen, Ma, Wenqing, Xiang, Qian, Mastriani, Emilio, Wang, Pengfei, Wang, Jiali, Liu, Shu-Lin, Johnston, Randal N, Köbel, Martin

“…Ovarian Clear Cell Carcinoma (OCCC) displays distinctive clinical and molecular characteristics and confers the worst prognosis among all ovarian carcinoma…”
Get full text

Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi by Liu, Wei-Qiao, Feng, Ye, Wang, Yan, Zou, Qing-Hua, Chen, Fang, Guo, Ji-Tao, Peng, Yi-Hong, Jin, Yan, Li, Yong-Guo, Hu, Song-Nian, Johnston, Randal N, Liu, Gui-Rong, Liu, Shu-Lin

“…Although over 1400 Salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e.g., Salmonella typhi and S. paratyphi C, cause typhoid, a…”
Get full text

Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells by Hamano, Shingo, Mori, Yoshinori, Aoyama, Mineyoshi, Kataoka, Hiromi, Tanaka, Mamoru, Ebi, Masahide, Kubota, Eiji, Mizoshita, Tsutomu, Tanida, Satoshi, Johnston, Randal N, Asai, Kiyofumi, Joh, Takashi

“…Highlights • Trastuzumab is effective for HER2-overexpressing gastric cancer therapy. • Oncolytic reovirus is currently undergoing clinical trials…”
Get full text

Defining natural species of bacteria: clear-cut genomic boundaries revealed by a turning point in nucleotide sequence divergence by Tang, Le, Li, Yang, Deng, Xia, Johnston, Randal N, Liu, Gui-Rong, Liu, Shu-Lin

“…Bacteria are currently classified into arbitrary species, but whether they actually exist as discrete natural species was unclear. To reveal genomic features…”
Get full text

Genetic boundaries delineate the potential human pathogen Salmonella bongori into discrete lineages: divergence and speciation by Wang, Xiaoyu, Zhu, Songling, Zhao, Jian-Hua, Bao, Hong-Xia, Liu, Huidi, Ding, Tie-Min, Liu, Gui-Rong, Li, Yong-Guo, Johnston, Randal N, Cao, Feng-Lin, Tang, Le, Liu, Shu-Lin

“…Salmonella bongori infect mainly cold-blooded hosts, but infections by S. bongori in warm-blooded hosts have been reported. We hypothesized that S. bongori…”
Get full text

Biobank bootstrapping: is biobank sustainability possible through cost recovery? by Albert, Monique, Bartlett, John, Johnston, Randal N, Schacter, Brent, Watson, Peter

“…The pre-eminent goal of biobanks is to accelerate scientific discovery and support improvements in healthcare through the supply of high quality biospecimens…”
Get more information

Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells by KAEWPIBOON, CHUTIMA, SRISUTTEE, RATAKORN, MALILAS, WARAPORN, MOON, JEONG, OH, SANGTAEK, JEONG, HYE GWANG, JOHNSTON, RANDAL N, ASSAVALAPSAKUL, WANCHAI, CHUNG, YOUNG-HWA

“…Despite efforts to develop efficient chemotherapeutic drug strategies to treat cancer, acquired drug resistance is a commonly encountered problem. In the…”
Get full text

Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells by KAEWPIBOON, CHUTIMA, SURAPINIT, SERM, MALILAS, WARAPORN, MOON, JEONG, PHUWAPRAISIRISAN, PREECHA, TIP-PYANG, SANTI, JOHNSTON, RANDAL N, KOH, SANG SEOK, ASSAVALAPSAKUL, WANCHAI, CHUNG, YOUNG-HWA

“…During the screening of natural chemicals that can reverse multidrug resistance in human A549 lung cancer cells resistant to etoposide (A549RT-eto), we…”
Get full text

Oncolytic Viral Therapy for Prostate Cancer: Efficacy of Reovirus as a Biological Therapeutic by THIRUKKUMARAN, Chandini M, NODWELL, Michael J, NISHIKAWA, Sandra, DONNELLY, Bryan, COFFEY, Matt, TRPKOV, Kiril, FONSECA, Kevin, SPURRELL, Jason, MORRIS, Don G, HIRASAWA, Kensuke, SHI, Zhong-Qiao, DIAZ, Roman, LUIDER, Joanne, JOHNSTON, Randal N, FORSYTH, Peter A, MAGLIOCCO, Anthony M, LEE, Patrick

“…Reovirus is a nonattenuated double-stranded RNA virus that exploits aberrant signaling pathways allowing selective cytotoxicity against multiple cancer…”
Get full text

Anti-tumor efficacy of oncolytic reovirus against gastrointestinal stromal tumor cells by Inagaki, Yusuke, Kubota, Eiji, Mori, Yoshinori, Aoyama, Mineyoshi, Kataoka, Hiromi, Johnston, Randal N, Joh, Takashi

“…Imatinib, a multitargeted receptor tyrosine kinase inhibitor, is used as the standard initial therapy against inoperable gastrointestinal stromal tumor (GIST)…”
Get full text

Double-deleted vaccinia virus in virotherapy for refractory and metastatic pediatric solid tumors by Lun, Xueqing, Ruan, Yibing, Jayanthan, Aarthi, Liu, David J., Singh, Anjali, Trippett, Tanya, Bell, John, Forsyth, Peter, Johnston, Randal N., Narendran, Aru

“…Previous studies have shown successful antitumor effects of systemically delivered double-deleted vaccinia virus (vvDD) against a number of adult tumor models,…”
Get full text