Search Results - "Johnston, Matthew D."
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A dynamical framework for modeling fear of infection and frustration with social distancing in COVID-19 spread
Published in Mathematical biosciences and engineering : MBE (01-11-2020)“…We introduce a novel modeling framework for incorporating fear of infection and frustration with social distancing into disease dynamics. We show that the…”
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A framework for deriving analytic steady states of biochemical reaction networks
Published in PLoS computational biology (01-04-2023)“…The long-term behaviors of biochemical systems are often described by their steady states. Deriving these states directly for complex networks arising from…”
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A data-validated temporary immunity model of COVID-19 spread in Michigan
Published in Mathematical biosciences and engineering : MBE (01-01-2022)“…We introduce a distributed-delay differential equation disease spread model for COVID-19 spread. The model explicitly incorporates the population's…”
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A Mathematical Study of COVID-19 Spread by Vaccination Status in Virginia
Published in Applied sciences (01-02-2022)“…We introduce a novel n-stage vaccination model and corresponding system of differential equations that stratify a population according to their vaccination…”
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A two-strain model of infectious disease spread with asymmetric temporary immunity periods and partial cross-immunity
Published in Mathematical biosciences and engineering : MBE (01-01-2023)“…We introduce a two-strain model with asymmetric temporary immunity periods and partial cross-immunity. We derive explicit conditions for competitive exclusion…”
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Realizations of kinetic differential equations
Published in Mathematical biosciences and engineering : MBE (01-01-2020)“…The induced kinetic differential equations of a reaction network endowed with mass action type kinetics is a system of polynomial differential equations. The…”
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Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
Published in Proceedings of the National Academy of Sciences - PNAS (06-03-2007)“…Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome,…”
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Algorithmic Approach for a Unique Definition of the Next-Generation Matrix
Published in Mathematics (Basel) (01-01-2024)“…The basic reproduction number R0 is a concept which originated in population dynamics, mathematical epidemiology, and ecology and is closely related to the…”
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Translated Chemical Reaction Networks
Published in Bulletin of mathematical biology (01-05-2014)“…Many biochemical and industrial applications involve complicated networks of simultaneously occurring chemical reactions. Under the assumption of mass action…”
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Network Translation and Steady-State Properties of Chemical Reaction Systems
Published in Bulletin of mathematical biology (01-09-2018)“…Network translation has recently been used to establish steady-state properties of mass action systems by corresponding the given system to a generalized one…”
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Computing Weakly Reversible Deficiency Zero Network Translations Using Elementary Flux Modes
Published in Bulletin of mathematical biology (01-05-2019)“…We present a computational method for performing structural translation, which has been studied recently in the context of analyzing the steady states and…”
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Examples of Mathematical Modeling: Tales from the Crypt
Published in Cell cycle (Georgetown, Tex.) (01-09-2007)“…Mathematical modeling is being increasingly recognized within the biomedical sciences as an important tool that can aid the understanding of biological…”
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A computational approach to extinction events in chemical reaction networks with discrete state spaces
Published in Mathematical biosciences (01-12-2017)“…•Recent results give conditions for extinction events in reaction networks with discrete state spaces.•The conditions consist of generating a series of systems…”
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A Computational Approach to Steady State Correspondence of Regular and Generalized Mass Action Systems
Published in Bulletin of mathematical biology (01-06-2015)“…It has been recently observed that the dynamical properties of mass action systems arising from many models of biochemical reaction networks can be…”
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A Deficiency-Based Approach to Parametrizing Positive Equilibria of Biochemical Reaction Systems
Published in Bulletin of mathematical biology (01-04-2019)“…We present conditions which guarantee a parametrization of the set of positive equilibria of a generalized mass-action system. Our main results state that (1)…”
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Conditions for extinction events in chemical reaction networks with discrete state spaces
Published in Journal of mathematical biology (01-05-2018)“…We study chemical reaction networks with discrete state spaces and present sufficient conditions on the structure of the network that guarantee the system…”
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A computational approach to persistence, permanence, and endotacticity of biochemical reaction systems
Published in Journal of mathematical biology (01-01-2016)“…We introduce a mixed-integer linear programming (MILP) framework capable of determining whether a chemical reaction network possesses the property of being…”
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Stochastic analysis of biochemical reaction networks with absolute concentration robustness
Published in Journal of the Royal Society interface (06-04-2014)“…It has recently been shown that structural conditions on the reaction network, rather than a ‘fine-tuning’ of system parameters, often suffice to impart…”
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On classes of reaction networks and their associated polynomial dynamical systems
Published in Journal of mathematical chemistry (01-10-2020)“…In the study of reaction networks and the polynomial dynamical systems that they generate, special classes of networks with important properties have been…”
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Computing weakly reversible linearly conjugate chemical reaction networks with minimal deficiency
Published in Mathematical biosciences (01-01-2013)“…► Mixed-integer linear programming algorithm derived. ► Capable of determining weakly reversible networks with minimal deficiency. ► We propose an…”
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