Search Results - "Johnston, Lee Ann"

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform by Shepherd, Malcolm, McSorley, Theresa, Olsen, Aileen E, Johnston, Lee Ann, Thomson, Neil C, Baillie, George S, Houslay, Miles D, Bolger, Graeme B

“…We have isolated cDNAs encoding PDE4B4, a new cAMP-specific phosphodiesterase (PDE4) isoform with novel properties. The amino acid sequence of PDE4B4…”
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Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene by Wallace, Derek A, Johnston, Lee Ann, Huston, Elaine, MacMaster, Douglas, Houslay, Thomas M, Cheung, York-Fong, Campbell, Lachlan, Millen, Jenni E, Smith, Robin A, Gall, Irene, Knowles, Richard G, Sullivan, Michael, Houslay, Miles D

“…PDE4A11 is a novel cAMP-specific phosphodiesterase that is conserved in humans, mouse, rat, pig, and bat. Exon-1(4A11) encodes its unique, 81 amino acid…”
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Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene by Johnston, Lee Ann, Erdogan, Suat, Cheung, York Fong, Sullivan, Michael, Barber, Rachael, Lynch, Martin J, Baillie, George S, Van Heeke, Gino, Adams, David R, Huston, Elaine, Houslay, Miles D

“…PDE4A7 is an isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene that fails to hydrolyse cAMP and whose transcripts are widely expressed…”
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The investigation of two novel PDE4A enzymes by Johnston, Lee Ann

“…As the central function of PDEs within cells is to control the levels of the cyclic nucleotides, it was surprising to find that the PDE4A gene encoded a splice…”
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