Search Results - "Johnston, Jeffrey M."

The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls by Jalanka, Jonna, Major, Giles, Murray, Kathryn, Singh, Gulzar, Nowak, Adam, Kurtz, Caroline, Silos-Santiago, Inmaculada, Johnston, Jeffrey M, de Vos, Willem M, Spiller, Robin

“…Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic…”
Get full text

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate by Castro, Joel, Harrington, Andrea M, Hughes, Patrick A, Martin, Christopher M, Ge, Pei, Shea, Courtney M, Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B, MacDougall, James E, Lavins, Bernard J, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Johnston, Jeffrey M, Currie, Mark G, Blackshaw, L. Ashley, Brierley, Stuart M

“…Background & Aims Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel…”
Get full text

Two Randomized Trials of Linaclotide for Chronic Constipation by Lembo, Anthony J, Schneier, Harvey A, Shiff, Steven J, Kurtz, Caroline B, MacDougall, James E, Jia, Xinwei D, Shao, James Z, Lavins, Bernard J, Currie, Mark G, Fitch, Donald A, Jeglinski, Brenda I, Eng, Paul, Fox, Susan M, Johnston, Jeffrey M

“…In two 12-week trials, linaclotide, a minimally absorbed peptide agonist of the guanylate cyclase-C receptor, increased the frequency of spontaneous bowel…”
Get full text

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial by Lacy, Brian E, Schey, Ron, Shiff, Steven J, Lavins, Bernard J, Fox, Susan M, Jia, Xinwei D, Blakesley, Rick E, Hao, Xinming, Cronin, Jacquelyn A, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M, Lembo, Anthony J

“…Abdominal bloating is a common and bothersome symptom of chronic idiopathic constipation. The objective of this trial was to evaluate the efficacy and safety…”
Get full text

A Phase II Multicenter Double-Blind Placebo-Controlled Study of Ethyl Pyruvate in High-Risk Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass by Bennett-Guerrero, Elliott, MD, Swaminathan, Madhav, MD, Grigore, Alina M., MD, Roach, Gary W., MD, Aberle, Laura G., BsPH, Johnston, Jeffrey M., MD, Fink, Mitchell P., MD

“…Objective Ethyl pyruvate (EP) is an investigational drug that has been shown to protect animals in several models of critical illness including myocardial or…”
Get full text

High‐dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double‐blind, placebo‐controlled study with a long‐term open‐label extension study in Japan by Fukudo, Shin, Miwa, Hiroto, Nakajima, Atsushi, Kinoshita, Yoshikazu, Kosako, Masanori, Hayashi, Kenta, Akiho, Hiraku, Kuroishi, Kentaro, Johnston, Jeffrey M, Currie, Mark, Ohkusa, Toshifumi

“…Background A previous phase II dose‐ranging study of linaclotide in a Japanese chronic constipation (CC) population showed that 0.5 mg was the most effective…”
Get full text

A randomized controlled and long‐term linaclotide study of irritable bowel syndrome with constipation patients in Japan by Fukudo, Shin, Miwa, Hiroto, Nakajima, Atsushi, Haruma, Ken, Kosako, Masanori, Nakagawa, Ayako, Akiho, Hiraku, Yamaguchi, Yusuke, Johnston, Jeffrey M., Currie, Mark, Kinoshita, Yoshikazu

“…Background Clinical testing was required to verify the effect of linaclotide 0.5 mg/d in patients with irritable bowel syndrome with constipation (IBS‐C) in…”
Get full text

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety by CHEY, William D, LEMBO, Anthony J, BAIRD, Mollie J, SCHNEIER, Harvey A, JOHNSTON, Jeffrey M, LAVINS, Bernard J, SHIFF, Steven J, KURTZ, Caroline B, CURRIE, Mark G, MACDOUGALL, James E, JIA, Xinwei D, SHAO, James Z, FITCH, Donald A

“…Linaclotide is a minimally absorbed peptide guanylate cyclase-C agonist. The objective of this trial was to determine the efficacy and safety of linaclotide…”
Get full text

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation by RAO, Satish, LEMBO, Anthony J, FOX, Susan M, SCHNEIER, Harvey A, KURTZ, Caroline B, JOHNSTON, Jeffrey M, SHIFF, Steven J, LAVINS, Bernard J, CURRIE, Mark G, JIA, Xinwei D, SHI, Kelvin, MACDOUGALL, James E, SHAO, James Z, ENG, Paul

“…Linaclotide is a minimally absorbed guanylate cyclase-C agonist. The objective of this trial was to determine the efficacy and safety of linaclotide in…”
Get full text

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation by Johnston, Jeffrey M, Kurtz, Caroline B, MacDougall, James E, Lavins, Bernard J, Currie, Mark G, Fitch, Donald A, O'Dea, Chris, Baird, Mollie, Lembo, Anthony J

“…Background & Aims Linaclotide, a minimally absorbed, 14-amino acid peptide agonist of guanylate cyclase-C, has shown benefit in a proof-of-concept study for…”
Get full text

Dose‐finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double‐blind, and placebo‐controlled study by Fukudo, Shin, Miwa, Hiroto, Nakajima, Atsushi, Kinoshita, Yoshikazu, Kosako, Masanori, Nakagawa, Ayako, Akiho, Hiraku, Kuroishi, Kentaro, Johnston, Jeffrey M., Currie, Mark, Ohkusa, Toshifumi

“…Background Based on the previous phase II/III studies of irritable bowel syndrome with constipation (IBS‐C) in Japan that demonstrated the efficacy and safety…”
Get full text

Efficacy of Linaclotide for Patients With Chronic Constipation by Lembo, Anthony J, Kurtz, Caroline B, MacDougall, James E, Lavins, B.J, Currie, Mark G, Fitch, Donald A, Jeglinski, Brenda I, Johnston, Jeffrey M

“…Background & Aims Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates intestinal fluid secretion and…”
Get full text

Linaclotide in irritable bowel syndrome with constipation: A Phase 3 randomized trial in China and other regions by Yang, Yunsheng, Fang, Jingyuan, Guo, Xiaozhong, Dai, Ning, Shen, Xizhong, Yang, Youlin, Sun, Jing, Bhandari, Bal Raj, Reasner, David S, Cronin, Jacquelyn A, Currie, Mark G, Johnston, Jeffrey M, Zeng, Peter, Montreewasuwat, Niwat, Chen, George Zhijian, Lim, Sam

“…Background and Aim Linaclotide is a guanylate cyclase‐C agonist approved in multiple countries to treat irritable bowel syndrome with constipation (IBS‐C)…”
Get full text

Effect of 5 Days Linaclotide on Transit and Bowel Function in Females With Constipation-Predominant Irritable Bowel Syndrome by Andresen, Viola, Camilleri, Michael, Busciglio, Irene A, Grudell, April, Burton, Duane, McKinzie, Sanna, Foxx–Orenstein, Amy, Kurtz, Caroline B, Sharma, Vineeta, Johnston, Jeffrey M, Currie, Mark G, Zinsmeister, Alan R

“…Background & Aims: Oral linaclotide, a novel agonist of guanylate cylase-C, stimulates intestinal fluid secretion and transit, and decreases visceral…”
Get full text

Response to Miner et al by Currie, Mark G, Shiff, Steven J, Schneier, Harvey A, Johnston, Jeffrey M

Get full text

Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation by Rao, Satish S.C, Quigley, Eamonn M.M, Shiff, Steven J, Lavins, Bernard J, Kurtz, Caroline B, MacDougall, James E, Currie, Mark G, Johnston, Jeffrey M

“…Background & Aims Patients with irritable bowel syndrome with constipation (IBS-C) have abdominal symptoms that vary in severity. Linaclotide, a guanylate…”
Get full text

Clarification of Linaclotide Clinical Trial Information in a Recent Review on Constipation by Johnston, Jeffrey M, Weissman, Taryn

Get full text

Linaclotide is Effective and Safe for Patients with Irritable Bowel Syndrome with Constipation in Japan: A Phase III Randomized, Double-Blind, and Placebo-Controlled and Long-Term Extension Study by Fukudo, Shin, Miwa, Hiroto, Nakajima, Atsushi, Haruma, Ken, Kosako, Masanori, Nakagawa, Ayako, Akiho, Hiraku, Yamaguchi, Yusuke, Johnston, Jeffrey M, Currie, Mark, Kinoshita, Yoshikazu

Get full text

Dose-Finding of Linaclotide for Patients with Chronic Constipation in Japan: A Phase II Randomized, Double-Blind, and Placebo-Controlled Study by Fukudo, Shin, Miwa, Hiroto, Nakajima, Atsushi, Kinoshita, Yoshikazu, Kosako, Masanori, Nakagawa, Ayako, Akiho, Hiraku, Kuroishi, Kentarou, Johnston, Jeffrey M, Currie, Mark, Ohkusa, Toshifumi

Get full text

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation by JOHNSTON, Jeffrey M, KURTZ, Caroline B, DROSSMAN, Douglas A, LEMBO, Anthony J, JEGLINSKI, Brenda I, MACDOUGALL, James E, ANTONELLI, Stephen M, CURRIE, Mark G

“…Chronic constipation is a common gastrointestinal disorder with limited treatment options. Oral administration of linaclotide, a novel peptide agonist of…”
Get full text