Search Results - "Johnston, Graham A R"

Muscimol as an Ionotropic GABA Receptor Agonist by Johnston, Graham A. R.

“…Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the…”
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Advantages of an antagonist: bicuculline and other GABA antagonists by Johnston, Graham AR

“…The convulsant alkaloid bicuculline continues to be investigated more than 40 years after the first publication of its action as an antagonist of receptors for…”
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Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids by Johnston, Graham A. R.

“…Analogues of the neurotransmitter GABA containing unsaturated bonds are restricted in the conformations they can attain. This review traces three such…”
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Stress and GABAA receptors by Skilbeck, Kelly J, Johnston, Graham A.R, Hinton, Tina

“…J. Neurochem. (2010) 112, 1115-1130. GABAA receptors are sensitive to subtle changes in the environment in both early-life and adulthood. These neurochemical…”
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The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice by Fernandez, Sebastian P., Nguyen, Michael, Yow, Tin Thing, Chu, Cindy, Johnston, Graham A. R., Hanrahan, Jane R., Chebib, Mary

“…The consumption of flavonoid-rich foods, in particular fruits and vegetables, has been epidemiologically associated with a reduced risk of heart disease,…”
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Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone by Hall, Belinda J., Karim, Nasiara, Chebib, Mary, Johnston, Graham A. R., Hanrahan, Jane R.

“…We evaluated the effects of 6-methoxyflavanone and 6-methoxyflavone on wild-type α1/α2β2γ2L GABA A and ρ1 GABA C receptors and on mutant ρ1I307S, ρ1W328 M,…”
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Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin‐Q by Yow, Tin T, Pera, Elena, Absalom, Nathan, Heblinski, Marika, Johnston, Graham AR, Hanrahan, Jane R, Chebib, Mary

“…BACKGROUND G protein‐coupled inwardly rectifying potassium (KIR3) channels are important proteins that regulate numerous physiological processes including…”
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Flavonoid modulation of GABAA receptors by Hanrahan, Jane R., Chebib, Mary, Johnston, Graham A. R.

“…There has been a resurgence of interest in synthetic and plant‐derived flavonoids as modulators of γ‐amino butyric acid‐A (GABAA) receptor function influencing…”
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Central nervous system depressant action of flavonoid glycosides by Fernández, Sebastián P., Wasowski, Cristina, Loscalzo, Leonardo M., Granger, Renee E., Johnston, Graham A.R., Paladini, Alejandro C., Marder, Mariel

“…The pharmacological effects on the central nervous system (CNS) of a range of available flavonoid glycosides were explored and compared to those of the…”
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The origins and early history of neurochemistry and its societies by Boullerne, Anne I., Foley, Paul, Turner, Anthony J., Johnston, Graham A.R., Beart, Philip M.

“…At the 2017 joint meeting of the International Society for Neurochemistry (ISN) and the European Society for Neurochemistry, 150 years of neurochemistry – the…”
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Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory by Chebib, Mary, Hinton, Tina, Schmid, Katrina L, Brinkworth, Darren, Qian, Haohua, Matos, Susana, Kim, Hye-Lim, Abdel-Halim, Heba, Kumar, Rohan J, Johnston, Graham A R, Hanrahan, Jane R

“…This study reports pharmacological and physiological effects of cis- and trans-(3-aminocyclopentanyl)butylphosphinic acid (cis- and trans-3-ACPBPA). These…”
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GABA-Activated Ligand Gated Ion Channels:  Medicinal Chemistry and Molecular Biology by Chebib, Mary, Johnston, Graham A. R

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2′‐Methoxy‐6‐methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABAA receptors by Karim, Nasiara, Curmi, John, Gavande, Navnath, Johnston, Graham AR, Hanrahan, Jane R, Tierney, M Louise, Chebib, Mary

“…BACKGROUND AND PURPOSE Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate…”
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GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid by Locock, Katherine E. S., Johnston, Graham A. R., Allan, Robin D.

“…The incorporation of extra binding groups onto known ligands is a powerful tool for the development of more potent and selective agents at target sites such as…”
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Targeting GABAC Receptors Improves Post-Stroke Motor Recovery by van Nieuwenhuijzen, Petra S., Parker, Kim, Liao, Vivian, Houlton, Josh, Kim, Hye-Lim, Johnston, Graham A. R., Hanrahan, Jane R., Chebib, Mary, Clarkson, Andrew N.

“…Ischemic stroke remains a leading cause of disability worldwide, with limited treatment options available. This study investigates GABAC receptors as novel…”
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γ‑Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4‑Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates by Locock, Katherine E. S, Yamamoto, Izumi, Tran, Priscilla, Hanrahan, Jane R, Chebib, Mary, Johnston, Graham A. R, Allan, Robin D

“…Series of compounds were generated via the bioisosteric replacement of the carboxylate of 4-ACPCA (2) with hydroxamate or amide groups. All compounds from this…”
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GABA, epigallocatechin gallate, tea, and the gut-brain axis by Hinton, Tina, Johnston, Graham A.R.

“…Our investigations on GABA-enriched tea and the reduction of stress in a student cohort have shown that more than just GABA may be involved. The effects of…”
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Neurochemicals for the Investigation of GABAC Receptors by Johnston, Graham A. R., Chebib, Mary, Hanrahan, Jane R., Mewett, Kenneth N.

“…GABA C receptors are being investigated for their role in many aspects of nervous system function including memory, myopia, pain and sleep. There is evidence…”
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GABA-enriched teas as neuro-nutraceuticals by Hinton, Tina, Johnston, Graham A.R.

“…Teas enriched in GABA are consumed for their beneficial effects on blood pressure, stress and anxiety. These effects may involve actions of GABA on the central…”
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Milestone review: GABA, from chemistry, conformations, ionotropic receptors, modulators, epilepsy, flavonoids, and stress to neuro‐nutraceuticals by Johnston, Graham A. R., Beart, Philip M.

“…Arising out of a PhD project more than 50 years ago to synthesise analogues of the neurotransmitter GABA, a series of new chemical entities were found to have…”
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