Search Results - "Johnston, Carl J."

Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction? by Williams, Jacqueline P, Johnston, Carl J, Finkelstein, Jacob N

“…Due to the radiosensitivity of the lung, toxic endpoints, in the form of radiation pneumonitis and pulmonary fibrosis, are relatively frequent outcomes…”
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Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation by Groves, Angela M., Johnston, Carl J., Misra, Ravi S., Williams, Jacqueline P., Finkelstein, Jacob N.

“…Purpose: Thoracic irradiation injures lung parenchyma, triggering inflammation and immune cell activation, leading to pneumonitis and fibrosis. Macrophage…”
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Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment by Mills, Bradley N., Connolly, Kelli A., Ye, Jian, Murphy, Joseph D., Uccello, Taylor P., Han, Booyeon J., Zhao, Tony, Drage, Michael G., Murthy, Aditi, Qiu, Haoming, Patel, Ankit, Figueroa, Nathania M., Johnston, Carl J., Prieto, Peter A., Egilmez, Nejat K., Belt, Brian A., Lord, Edith M., Linehan, David C., Gerber, Scott A.

“…Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies…”
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Short-term and bystander effects of radiation on murine submandibular glands by Uchida, Hitoshi, Ingalls, Matthew H, Maruyama, Eri O, Johnston, Carl J, Hernady, Eric, Faustoferri, Roberta C, Ovitt, Catherine E

“…Many patients treated for head and neck cancers experience salivary gland hypofunction due to radiation damage. Understanding the mechanisms of cellular damage…”
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The effect of air pollution on the transcriptomics of the immune response to respiratory infection by Croft, Daniel P., Burton, David S., Nagel, David J., Bhattacharya, Soumyaroop, Falsey, Ann R., Georas, Steve N., Hopke, Philip K., Johnston, Carl J., Kottmann, R. Matthew, Litonjua, Augusto A., Mariani, Thomas J., Rich, David Q., Thevenet-Morrison, Kelly, Thurston, Sally W., Utell, Mark J., McCall, Matthew N.

“…Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism…”
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A Potential Biomarker for Predicting the Risk of Radiation-Induced Fibrosis in the Lung by Groves, Angela M, Williams, Jacqueline P, Hernady, Eric, Reed, Christina, Fenton, Bruce, Love, Tanzy, Finkelstein, Jacob N, Johnston, Carl J

“…Biomarkers could play an essential role during triage in the aftermath of a radiological event, where exposure to radiation will be heterogeneous and…”
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Muscle‐specific functional deficits and lifelong fibrosis in response to paediatric radiotherapy and tumour elimination by Kallenbach, Jacob G., Bachman, John F., Paris, Nicole D., Blanc, Roméo S., O'Connor, Thomas, Furati, Esraa, Williams, Jacqueline P., Chakkalakal, Joe V.

“…Background As paediatric cancer survivors are living into adulthood, they suffer from the age‐related, accelerated decline of functional skeletal muscle…”
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Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer by Ye, Jian, Mills, Bradley N, Qin, Shuyang S, Garrett-Larsen, Jesse, Murphy, Joseph D, Uccello, Taylor P, Han, Booyeon J, Vrooman, Tara G, Johnston, Carl J, Lord, Edith M, Belt, Brian A, Linehan, David C, Gerber, Scott A

“…BackgroundStereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces…”
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Protein thiol oxidation in the rat lung following e-cigarette exposure by Wang, Juan, Zhang, Tong, Johnston, Carl J., Kim, So-Young, Gaffrey, Matthew J., Chalupa, David, Feng, Guanqiao, Qian, Wei-Jun, McGraw, Matthew D., Ansong, Charles

“…E-cigarette (e-cig) aerosols are complex mixtures of various chemicals including humectants (propylene glycol (PG) and vegetable glycerin (VG)), nicotine, and…”
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Neonatal hypoxic ischemic encephalopathy increases acute kidney injury urinary biomarkers in a rat model by Groves, Angela M., Johnston, Carl J., Beutner, Gisela G., Dahlstrom, Jane E., Koina, Mark, O'Reilly, Michael A., Porter, George, Brophy, Patrick D., Kent, Alison L.

“…Hypoxic ischemic encephalopathy (HIE) is associated with acute kidney injury (AKI) in neonates with birth asphyxia. This study aimed to utilize urinary…”
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CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models by Ye, Jian, Gavras, Nicholas W, Keeley, David C, Hughson, Angela L, Hannon, Gary, Vrooman, Tara G, Lesch, Maggie L, Johnston, Carl J, Lord, Edith M, Belt, Brian A, Linehan, David C, Eyles, Jim, Gerber, Scott A

“…BackgroundStereotactic body radiotherapy (SBRT) induces immunogenic cell death, leading to subsequent antitumor immune response that is in part counterbalanced…”
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Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number by Bachman, John F., Blanc, Roméo S., Paris, Nicole D., Kallenbach, Jacob G., Johnston, Carl J., Hernady, Eric, Williams, Jacqueline P., Chakkalakal, Joe V.

“…During prepubertal development, muscle stem cells (satellite cells, SCs) actively contribute to myofiber growth. Because some SCs are active during this time,…”
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Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer by Hughson, Angela L., Hannon, Gary, Salama, Noah A., Vrooman, Tara G., Stockwell, Caroline A., Mills, Bradley N., Garrett-Larsen, Jesse, Qiu, Haoming, Katerji, Roula, Benoodt, Lauren, Johnston, Carl J., Murphy, Joseph D., Kruger, Emma, Ye, Jian, Gavras, Nicholas W., Keeley, David C., Qin, Shuyang S., Lesch, Maggie L., Muhitch, Jason B., Love, Tanzy M.T., Calvi, Laura M., Lord, Edith M., Luheshi, Nadia, Elyes, Jim, Linehan, David C., Gerber, Scott A.

“…Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this…”
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Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress by O'Connor, Thomas N, Kallenbach, Jacob G, Orciuoli, Haley M, Paris, Nicole D, Bachman, John F, Johnston, Carl J, Hernady, Eric, Williams, Jacqueline P, Dirksen, Robert T, Chakkalakal, Joe V

“…Radiotherapy is commonly used to treat childhood cancers and can have adverse effects on muscle function, but the underlying mechanisms have yet to be fully…”
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Diacetyl Vapor Inhalation Induces Mixed, Granulocytic Lung Inflammation with Increased CD4 + CD25 + T Cells in the Rat by House, Emma L, Kim, So-Young, Johnston, Carl J, Groves, Angela M, Hernady, Eric, Misra, Ravi S, McGraw, Matthew D

“…Diacetyl (DA) is a highly reactive alpha diketone associated with flavoring-related lung disease. In rodents, acute DA vapor exposure can initiate an…”
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Early Alterations in Cytokine Expression in Adult Compared to Developing Lung in Mice after Radiation Exposure by Johnston, Carl J., Hernady, Eric, Reed, Christina, Thurston, Sally W., Finkelstein, Jacob N., Williams, Jacqueline P.

“…To assess early changes in the lung after low-dose radiation exposure that may serve as targets for mitigation of lung injury in the aftermath of a terrorist…”
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Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy by Uccello, Taylor P., Kintzel, Sarah A., Mills, Bradley N., Murphy, Joseph D., Garrett-Larsen, Jesse, Battaglia, Nicholas G., Rodriguez, Carlos J., Drage, Michael G., Ye, Jian, Love, Tanzy M.T., Johnston, Carl J., Repasky, Elizabeth A., Qiu, Haoming, Linehan, David C., Lord, Edith M., Gerber, Scott A.

“…Orthotopic tumors more closely recapitulate human cancers than do ectopic models; however, precision targeting of such internal tumors for radiation therapy…”
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Lung Irradiation Increases Mortality After Influenza A Virus Challenge Occurring Late After Exposure by Manning, Casey M., MS, Johnston, Carl J., PhD, Reed, Christina K., BS, Lawrence, B. Paige, PhD, Williams, Jacqueline P., PhD, Finkelstein, Jacob N., PhD

“…Purpose To address whether irradiation-induced changes in the lung environment alter responses to a viral challenge delivered late after exposure but before…”
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Radiation-Induced Pulmonary Fibrosis: Examination of Chemokine and Chemokine Receptor Families by Johnston, Carl J., Williams, Jacqueline P., Okunieff, Paul, Finkelstein, Jacob N.

“…Johnston, C. J., Williams, J. P., Okunieff, P. and Finkelstein, J. N. Radiation-Induced Pulmonary Fibrosis: Examination of Chemokine and Chemokine Receptor…”
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Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis by Groves, Angela M., Johnston, Carl J., Williams, Jacqueline P., Finkelstein, Jacob N.

“…Lung exposure to radiation induces an injury response that includes the release of cytokines and chemotactic mediators; these signals recruit immune cells to…”
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