Search Results - "Johnston, C. I"

Renoprotective effects of vasopeptidase inhibition in an experimental model of diabetic nephropathy by DAVIS, B. J, JOHNSTON, C. I, BURRELL, L. M, BURNS, W. C, KUBOTA, E, CAO, Z, COOPER, M. E, ALLEN, T. J

“…Although ACE inhibitors slow progression of diabetic renal disease, the mortality and morbidity is still high. As other hormonal factors are involved,…”
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Angiotensin receptor antagonists: focus on losartan by Johnston, C I

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Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats by YU, H. C. M, BURRELL, L. M, BLACK, M. J, WU, L. L, DILLEY, R. J, COOPER, M. E, JOHNSTON, C. I

“…The detrimental effects of high dietary salt intake may not only involve effects on blood pressure and organ hypertrophy but also lead to tissue fibrosis…”
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Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia by Fabiani, ME, Sourial, M, Thomas, WG, Johnston, CI, Frauman, AG

“…The renin-angiotensin system (RAS) is present in the human prostate and may be activated in benign prostatic hyperplasia (BPH), possibly contributing to the…”
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Identification of angiotensin converting enzyme 2 in the rodent retina by Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W. C., Thomas, M. C., Lew, R. A., Yarski, M., Smith, A. I., Cooper, M. E.

“…Purpose. An active renin-angiotensin system has been found in the retina of rats and humans. Angiotensin-converting enzyme 2 (ACE2) is a recently discovered…”
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Pathological Expression of Renin and Angiotensin II in the Renal Tubule after Subtotal Nephrectomy : Implications for the Pathogenesis of Tubulointerstitial Fibrosis by Gilbert, Richard E, Wu, Leonard L, Kelly, Darren J, Cox, Alison, Wilkinson-Berka, Jennifer L, Johnston, Colin I, Cooper, Mark E

“…The finding that the systemic renin-angiotensin system (RAS) is not activated in most types of chronic renal disease has led to the suggestion that a local,…”
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Localization of Angiotensin Converting Enzyme in Rat Heart by Yamada, Hiroshi, Fabris, Bruno, Allen, Andrew M, Jackson, Bruce, Johnston, Colin I, Mendelsohn, Frederick A.O

“…Angiotensin converting enzyme (ACE) was localized in rat heart by quantitative in vitro autoradiography with I-351A as the radioligand. The binding association…”
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Biochemistry and pharmacology of the renin-angiotensin system by JOHNSTON, C. I

“…Knowledge of the structure, function and distribution of the components of the renin-angiotensin-aldosterone system (RAS) and the integrated physiological role…”
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Mulga snake (Pseudechis australis) envenoming: a spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy - Australian Snakebite Project (ASP-19) by Johnston, C. I., Brown, S. G. A., O'Leary, M. A., Currie, B. J., Greenberg, R., Taylor, M., Barnes, C., White, J., Isbister, G. K.

“…Context. Mulga snakes (Pseudechis australis) are venomous snakes with a wide distribution in Australia. Objective. The objective of this study was to describe…”
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Reduced osmotic thirst in healthy elderly men by Phillips, P A, Bretherton, M, Johnston, C I, Gray, L

“…In response to water deprivation or heat stress, healthy elderly men experience reduced thirst compared with a young control group. Because water deprivation…”
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Localization of angiotensin-converting enzyme in the human prostate: pathological expression in benign prostatic hyperplasia by Nassis, Labrini, Frauman, Albert G., Ohishi, Mitsuru, Zhuo, Jialong, Casley, David J., Johnston, Colin I., Fabiani, Maurice E.

“…Benign prostatic hyperplasia (BPH) is the most common hyperplastic disease in man and it is characterized by increased cellular growth (stromal and epithelial…”
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In vivo inhibition of angiotensin receptors in the rat kidney by candesartan cilexetil: a comparison with losartan by Fabiani, Maurice E, Dinh, Diem T, Nassis, Labrini, Casley, David J, Johnston, Colin I

“…The present study examined the in vivo effects of candesartan cilexetil compared with losartan on angiotensin II (Ang II) receptor binding in the rat kidney…”
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Developmental expression of ACE2 in the SHR kidney: A role in hypertension? by Tikellis, C., Cooper, M.E., Bialkowski, K., Johnston, C.I., Burns, W.C., Lew, R.A., Smith, A.I., Thomas, M.C.

“…The abnormal development of the intrarenal renin–angiotensin system (RAS) is thought contribute to adult-onset hypertension in the spontaneously hypertensive…”
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Dual Inhibition of Neutral Endopeptidase and Angiotensin-Converting Enzyme in Rats With Hypertension and Diabetes Mellitus by Tikkanen, Tuula, Tikkanen, Ilkka, Rockell, Melinda D, Allen, Terri J, Johnston, Colin I, Cooper, Mark E, Burrell, Louise M

“…It has been suggested that combined inhibition of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) may lower blood pressure more effectively…”
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Antihypertensive and antihypertrophic effects of omapatrilat in SHR by Burrell, Louise M, Droogh, Joep, Man in’t Veld, Olivier, Rockell, Melinda D, Farina, Nicole K, Johnston, Colin I

“…Vasopeptidase inhibitors, such as omapatrilat are single molecules that simultaneously inhibit neutral endopeptidase (NEP) and angiotensin converting enzyme…”
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Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs by Farina, Nicole K, Johnston, Colin I, Burrell, Louise M

“…OBJECTIVEThe major advantage of dual inhibitors of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) is their ability to lower blood pressure…”
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Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy by Tikellis, Christos, Johnston, Colin I, Forbes, Josephine M, Burns, Wendy C, Burrell, Louise M, Risvanis, John, Cooper, Mark E

“…ABSTRACT—ACE2, initially cloned from a human heart, is a recently described homologue of angiotensin-converting enzyme (ACE) but contains only a single…”
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Neurohumoral responses to chronic myocardial infarction in rats by HODSMAN, G. P, KOHZUKI, M, HOWES, L. G, SUMITHRAN, E, TSUNODA, K, JOHNSTON, C. I

“…In chronic cardiac failure, various neurohumoral mechanisms are activated to sustain blood volume, blood pressure, and organ perfusion. Using the coronary…”
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Comparative studies of tissue inhibition by angiotensin converting enzyme inhibitors by Johnston, C I, Fabris, B, Yamada, H, Mendelsohn, F A, Cubela, R, Sivell, D, Jackson, B

“…There is increasing evidence that inhibition of tissue angiotensin converting enzyme (ACE) is important for the pharmacokinetics and pharmacodynamic effects of…”
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Blood Pressure-Lowering Effect of an Orally Active Vasopressin V1 Receptor Antagonist in Mineralocorticoid Hypertension in the Rat by Burrell, Louise M, Phillips, Paddy A, Stephenson, J M, Risvanis, J, Rolls, K A, Johnston, C I

“…We studied the contribution of vasopressin to the maintenance of high blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertension in the rat using…”
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