Search Results - "Johnston, Angus P. R."

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery by Smith, Samuel A, Selby, Laura I, Johnston, Angus P. R, Such, Georgina K

“…Many emerging therapies rely on the delivery of biological cargo into the cytosol. Nanoparticle delivery systems hold great potential to deliver these…”
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Engineered hydrogen-bonded polymer multilayers: from assembly to biomedical applications by Such, Georgina K, Johnston, Angus P R, Caruso, Frank

“…Over the last two decades the layer-by-layer (LbL) assembly technique has become a highly versatile platform for the synthesis of nanoengineered thin films and…”
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Resolving subcellular pH with a quantitative fluorescent lifetime biosensor by Rennick, Joshua J., Nowell, Cameron J., Pouton, Colin W., Johnston, Angus P. R.

“…Changes in sub-cellular pH play a key role in metabolism, membrane transport, and triggering cargo release from therapeutic delivery systems. Most methods to…”
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Engineering Particles for Therapeutic Delivery: Prospects and Challenges by Yan, Yan, Such, Georgina K, Johnston, Angus P. R, Best, James P, Caruso, Frank

“…Nanoengineered particles that can facilitate drug formulation and passively target tumors have reached the clinic in recent years. These early successes have…”
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Interfacing Materials Science and Biology for Drug Carrier Design by Such, Georgina K., Yan, Yan, Johnston, Angus P. R., Gunawan, Sylvia T., Caruso, Frank

“…Over the last ten years, there has been considerable research interest in the development of polymeric carriers for biomedicine. Such delivery systems have the…”
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Next generation, sequentially assembled ultrathin films: beyond electrostatics by Quinn, John F, Johnston, Angus P R, Such, Georgina K, Zelikin, Alexander N, Caruso, Frank

“…Over the last 15 years, the layer-by-layer (LbL) assembly technology has proven to be a versatile method for surface modification. This approach is likely to…”
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Tuning the Formation and Degradation of Layer-by-Layer Assembled Polymer Hydrogel Microcapsules by Becker, Alisa L, Zelikin, Alexander N, Johnston, Angus P. R, Caruso, Frank

“…Engineered polymer capsules are finding widespread importance in the delivery of encapsulated toxic or fragile drugs. The effectiveness of polymer capsules as…”
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Organic Arsenicals As Efficient and Highly Specific Linkers for Protein/Peptide–Polymer Conjugation by Wilson, Paul, Anastasaki, Athina, Owen, Matthew R, Kempe, Kristian, Haddleton, David M, Mann, Sarah K, Johnston, Angus P. R, Quinn, John F, Whittaker, Michael R, Hogg, Philip J, Davis, Thomas P

“…The entropy-driven affinity of trivalent (in)­organic arsenicals for closely spaced dithiols has been exploited to develop a novel route to…”
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Quantifying Nanoparticle Internalization Using a High Throughput Internalization Assay by Mann, Sarah K., Czuba, Ewa, Selby, Laura I., Such, Georgina K., Johnston, Angus P. R.

“…Purpose The internalization of nanoparticles into cells is critical for effective nanoparticle mediated drug delivery. To investigate the kinetics and…”
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Ultrathin, Responsive Polymer Click Capsules by Such, Georgina K., Tjipto, Elvira, Postma, Almar, Johnston, Angus P. R., Caruso, Frank

“…We report a general click chemistry approach for the layer-by-layer assembly of ultrathin, polymer films on particles and the subsequent formation of polymer…”
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Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules by Kamphuis, Marloes M. J, Johnston, Angus P. R, Such, Georgina K, Dam, Henk H, Evans, Richard A, Scott, Andrew M, Nice, Edouard C, Heath, Joan K, Caruso, Frank

“…Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining…”
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Redox-Active Polymer Microcapsules for the Delivery of a Survivin-Specific siRNA in Prostate Cancer Cells by Becker, Alisa L, Orlotti, Nicola Ivan, Folini, Marco, Cavalieri, Francesca, Zelikin, Alexander N, Johnston, Angus P. R, Zaffaroni, Nadia, Caruso, Frank

“…In this report, we describe the delivery of small interfering RNA (siRNA) using LbL-assembled microcapsules. The microcapsules are based on negatively charged…”
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A Programmable Sensor to Probe the Internalization of Proteins and Nanoparticles in Live Cells by Liu, Haiyin, Johnston, Angus P. R.

“…A molecular sensor has been developed to probe the internalization of proteins and nanoparticles into live cells. This simple, high‐throughput technique is…”
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A General Approach for DNA Encapsulation in Degradable Polymer Microcapsules by Zelikin, Alexander N, Becker, Alisa L, Johnston, Angus P. R, Wark, Kim L, Turatti, Fabio, Caruso, Frank

“…We report a general and facile method for the encapsulation of DNA in nanoengineered, degradable polymer microcapsules. Single-stranded (ss), linear…”
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DNA Multilayer Films on Planar and Colloidal Supports:  Sequential Assembly of Like-Charged Polyelectrolytes by Johnston, Angus P. R, Read, Elizabeth S, Caruso, Frank

“…Multilayer films comprising solely negatively charged polyelectrolytes were sequentially assembled based on DNA hybridization. Films prepared from alternating…”
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Targeting Cancer Cells: Controlling the Binding and Internalization of Antibody-Functionalized Capsules by Johnston, Angus P. R, Kamphuis, Marloes M. J, Such, Georgina K, Scott, Andrew M, Nice, Edouard C, Heath, Joan K, Caruso, Frank

“…The development of nanoengineered particles, such as polymersomes, liposomes, and polymer capsules, has the potential to offer significant advances in vaccine…”
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Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination by Reuter, Anika, Panozza, Scott E, Macri, Christophe, Dumont, Claire, Li, Jessica, Liu, Haiyin, Segura, Elodie, Vega-Ramos, Javier, Gupta, Nishma, Caminschi, Irina, Villadangos, Jose A, Johnston, Angus P R, Mintern, Justine D

“…Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as…”
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pH‐Responsive Polymer Nanoparticles for Drug Delivery by Deirram, Nayeleh, Zhang, Changhe, Kermaniyan, Sarah S., Johnston, Angus P. R., Such, Georgina K.

“…Stimuli‐responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many…”
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Human immune cell targeting of protein nanoparticles--caveospheres by Glass, Joshua J, Yuen, Daniel, Rae, James, Johnston, Angus P R, Parton, Robert G, Kent, Stephen J, De Rose, Robert

“…Nanotechnology has the power to transform vaccine and drug delivery through protection of payloads from both metabolism and off-target effects, while…”
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Tailoring the Interfaces between Nematic Liquid Crystal Emulsions and Aqueous Phases via Layer-by-Layer Assembly by Tjipto, Elvira, Cadwell, Katie D, Quinn, John F, Johnston, Angus P. R, Abbott, Nicholas L, Caruso, Frank

“…We report the assembly of polyelectrolyte multilayer (PEM) films at the interfaces of thermotropic liquid crystal (LC) droplets dispersed in an aqueous phase…”
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