Search Results - "Johnson, Steven M."

The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug by Johnson, Steven M., Connelly, Stephen, Fearns, Colleen, Powers, Evan T., Kelly, Jeffery W.

“…Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (i.e., undergo amyloidogenesis) in vivo. The process of TTR…”
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Determinants of nucleosome organization in primary human cells by Valouev, Anton, Johnson, Steven M., Boyd, Scott D., Smith, Cheryl L., Fire, Andrew Z., Sidow, Arend

“…Nucleosome positions mapped The organization of nucleosomes across the genome influences gene regulation, and understanding the mechanisms that underlie this…”
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Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function by Adams, Kevin, Weber, K Scott, Johnson, Steven M

“…Immune memory is a defining characteristic of adaptive immunity, but recent work has shown that the activation of innate immunity can also improve…”
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A high-resolution, nucleosome position map of C. elegans reveals a lack of universal sequence-dictated positioning by Valouev, Anton, Ichikawa, Jeffrey, Tonthat, Thaisan, Stuart, Jeremy, Ranade, Swati, Peckham, Heather, Zeng, Kathy, Malek, Joel A, Costa, Gina, McKernan, Kevin, Sidow, Arend, Fire, Andrew, Johnson, Steven M

“…Using the massively parallel technique of sequencing by oligonucleotide ligation and detection (SOLiD; Applied Biosystems), we have assessed the in vivo…”
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Ubiquitous heterogeneity and asymmetry of the chromatin environment at regulatory elements by Kundaje, Anshul, Kyriazopoulou-Panagiotopoulou, Sofia, Libbrecht, Max, Smith, Cheryl L, Raha, Debasish, Winters, Elliott E, Johnson, Steven M, Snyder, Michael, Batzoglou, Serafim, Sidow, Arend

“…Gene regulation at functional elements (e.g., enhancers, promoters, insulators) is governed by an interplay of nucleosome remodeling, histone modifications,…”
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RAS Is Regulated by the let-7 MicroRNA Family by Johnson, Steven M., Grosshans, Helge, Shingara, Jaclyn, Byrom, Mike, Jarvis, Rich, Cheng, Angie, Labourier, Emmanuel, Reinert, Kristy L., Brown, David, Slack, Frank J.

“…MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer. The let-7 miRNA times seam…”
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An Exopolysaccharide from the Cyanobacterium Arthrospira platensis May Utilize CH−π Bonding: A Review of the Isolation, Purification, and Chemical Structure of Calcium-Spirulan by Gal, Jonathan L., Johnson, Steven M.

“…The CH−π bonding potential of a saccharide is determined primarily by the number of hydrogen atoms available for bonding and is reduced by side groups that…”
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Proximal-end bias from in-vitro reconstituted nucleosomes and the result on downstream data analysis by Bates, David A, Bates, Charles E, Earl, Andrew S, Skousen, Colin, Fetbrandt, Ashley N, Ritchie, Jordon, Bodily, Paul M, Johnson, Steven M

“…The most basic level of eukaryotic gene regulation is the presence or absence of nucleosomes on DNA regulatory elements. In an effort to elucidate in vivo…”
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Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors by Johnson, Steven M, Connelly, Stephen, Wilson, Ian A, Kelly, Jeffery W

“…To develop potent transthyretin (TTR) amyloidogenesis inhibitors that also display high binding selectivity in blood, it proves useful to systematically…”
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A reappraisal of ASXL1 mutation sites and the cohesin-binding motif in myeloid disease by Johnson, Steven M., Haberberger, James, Galeotti, Jonathan, Ramkissoon, Lori, Coombs, Catherine C., Richardson, Daniel R., Foster, Matthew C., Duncan, Daniel, Zeidner, Joshua F., Ferguson, Naomi L., Montgomery, Nathan D.

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A new approach for detecting riboswitches in DNA sequences by Havill, Jessen T, Bhatiya, Chinmoy, Johnson, Steven M, Sheets, Joseph D, Thompson, Jeffrey S

“…Riboswitches are short sequences of messenger RNA that can change their structural conformation to regulate the expression of adjacent genes. Computational…”
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Native State Kinetic Stabilization as a Strategy To Ameliorate Protein Misfolding Diseases:  A Focus on the Transthyretin Amyloidoses by Johnson, Steven M, Wiseman, R. Luke, Sekijima, Yoshiki, Green, Nora S, Adamski-Werner, Sara L, Kelly, Jeffery W

“…Small molecule-mediated protein stabilization inside or outside of the cell is a promising strategy to treat protein misfolding/misassembly diseases. Herein we…”
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Anticipation of Personal Genomics Data Enhances Interest and Learning Environment in Genomics and Molecular Biology Undergraduate Courses by Weber, K Scott, Jensen, Jamie L, Johnson, Steven M

“…An important discussion at colleges is centered on determining more effective models for teaching undergraduates. As personalized genomics has become more…”
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Flexibility and constraint in the nucleosome core landscape of Caenorhabditis elegans chromatin by Johnson, Steven M, Tan, Frederick J, McCullough, Heather L, Riordan, Daniel P, Fire, Andrew Z

“…Nucleosome positions within the chromatin landscape are known to serve as a major determinant of DNA accessibility to transcription factors and other…”
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Personal microbiome analysis improves student engagement and interest in Immunology, Molecular Biology, and Genomics undergraduate courses by Weber, K Scott, Bridgewater, Laura C, Jensen, Jamie L, Breakwell, Donald P, Nielsen, Brent L, Johnson, Steven M

“…A critical area of emphasis for science educators is the identification of effective means of teaching and engaging undergraduate students. Personal microbiome…”
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Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL by Sivinski, Jared, Ambrose, Andrew J, Panfilenko, Iliya, Zerio, Christopher J, Machulis, Jason M, Mollasalehi, Niloufar, Kaneko, Lynn K, Stevens, Mckayla, Ray, Anne-Marie, Park, Yangshin, Wu, Chunxiang, Hoang, Quyen Q, Johnson, Steven M, Chapman, Eli

“…As the GroES/GroEL chaperonin system is the only bacterial chaperone that is essential under all conditions, we have been interested in the development of…”
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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors by Ojo, Kayode K, Pfander, Claudia, Mueller, Natascha R, Burstroem, Charlotte, Larson, Eric T, Bryan, Cassie M, Fox, Anna M W, Reid, Molly C, Johnson, Steven M, Murphy, Ryan C, Kennedy, Mark, Mann, Henning, Leibly, David J, Hewitt, Stephen N, Verlinde, Christophe L M J, Kappe, Stefan, Merritt, Ethan A, Maly, Dustin J, Billker, Oliver, Van Voorhis, Wesley C

“…Effective control and eradication of malaria will require new tools to prevent transmission. Current antimalarial therapies targeting the asexual stage of…”
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Manipulating chromatin architecture in C. elegans by Carter, John L, Kempton, Colton E, Hales, Emily D. S, Johnson, Steven M

“…Abstract Background Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets…”
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Characterization of two related Erwinia myoviruses that are distant relatives of the PhiKZ-like Jumbo phages by Arens, Daniel K, Brady, T Scott, Carter, John L, Pape, Jenny A, Robinson, David M, Russell, Kerri A, Staley, Lyndsay A, Stettler, Jason M, Tateoka, Olivia B, Townsend, Michelle H, Whitley, Kiara V, Wienclaw, Trevor M, Williamson, Taryn L, Johnson, Steven M, Grose, Julianne H

“…Bacteriophages are a major force in the evolution of bacteria due to their sheer abundance as well as their ability to infect and kill their hosts and to…”
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Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies by Johnson, Steven M, Connelly, Stephen, Wilson, Ian A, Kelly, Jeffery W

“…To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements…”
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