Search Results - "Johnson, Rudolph C"

Detection of 30 Fentanyl Analogs by Commercial Immunoassay Kits by Wharton, Rebekah E, Casbohm, Jerry, Hoffmaster, Ryan, Brewer, Bobby N, Finn, M G, Johnson, Rudolph C

“…Health-care workers, laboratorians and overdose prevention centers rely on commercial immunoassays to detect the presence of fentanyl; however, the…”
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Immunomagnetic Separation and Quantification of Butyrylcholinesterase Nerve Agent Adducts in Human Serum by Sporty, Jennifer L. S, Lemire, Sharon W, Jakubowski, Edward M, Renner, Julie A, Evans, Ronald A, Williams, Robert F, Schmidt, Jurgen G, Schans, Marcel J. van der, Noort, Daan, Johnson, Rudolph C

“…A novel method for extracting butyrylcholinesterase (BuChE) from serum as a means of identifying and measuring nerve agent adducts to human BuChE is presented…”
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Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry by Hamelin, Elizabeth I., Schulze, Nicholas D., Shaner, Rebecca L., Coleman, Rebecca M., Lawrence, Richard J., Crow, Brian S., Jakubowski, E. M., Johnson, Rudolph C.

“…Although nerve agent use is prohibited, concerns remain for human exposure to nerve agents during decommissioning, research, and warfare. Exposure can be…”
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Measurement of Microcystin Activity in Human Plasma Using Immunocapture and Protein Phosphatase Inhibition Assay by Cunningham, Brady R, Wharton, Rebekah E, Lee, Christine, Mojica, Mike A, Krajewski, Logan C, Gordon, Shirley C, Schaefer, Adam M, Johnson, Rudolph C, Hamelin, Elizabeth I

“…Microcystins are toxic chemicals generated by certain freshwater cyanobacteria. These chemicals can accumulate to dangerous levels during harmful algal blooms…”
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Comparison of two automated solid phase extractions for the detection of ten fentanyl analogs and metabolites in human urine using liquid chromatography tandem mass spectrometry by Shaner, Rebecca L., Kaplan, Pearl, Hamelin, Elizabeth I., Bragg, William A., Johnson, Rudolph C.

“…•Two automated SPE methods were developed for analysis of fentanyl analogs and metabolites.•On- and off-line SPE methods were shown to have comparable…”
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Simultaneous Measurement of 3-Chlorotyrosine and 3,5-Dichlorotyrosine in Whole Blood, Serum and Plasma by Isotope Dilution HPLC–MS-MS by Crow, Brian S., Quiñones-González, Jennifer, Pantazides, Brooke G., Perez, Jonas W., Winkeljohn, W. Rucks, Garton, Joshua W., Thomas, Jerry D., Blake, Thomas A., Johnson, Rudolph C.

“…Chlorine is a public health concern and potential threat due to its high reactivity, ease and scale of production, widespread industrial use, bulk…”
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Quantitation of tetramethylene disulfotetramine in human urine using isotope dilution gas chromatography mass spectrometry (GC/MS and GC/MS/MS) by Hamelin, Elizabeth, Swaim, Leigh, Thomas, Jerry, Kobelski, Robert, Johnson, Rudolph C.

“…Tetramethylene disulfotetramine (tetramine) is a rodenticide associated with numerous poisonings was extracted and quantified in human urine using both gas…”
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Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors by Lockridge, Oksana, Norgren, Robert B, Johnson, Rudolph C, Blake, Thomas A

“…Acetylcholinesterase (AChE) is the physiologically important target for organophosphorus toxicants (OP) including nerve agents and pesticides…”
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Monoclonal Antibodies That Recognize Various Folding States of Pure Human Butyrylcholinesterase Can Immunopurify Butyrylcholinesterase from Human Plasma Stored at Elevated Temperatures by Peng, Hong, Blake, Thomas A, Johnson, Rudolph C, Dafferner, Alicia J, Brimijoin, Stephen, Lockridge, Oksana

“…Human plasma to be analyzed for exposure to cholinesterase inhibitors is stored at 4 °C or lower to prevent denaturation of human butyrylcholinesterase…”
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Quantification of Saxitoxin and Neosaxitoxin in Human Urine Utilizing Isotope Dilution Tandem Mass Spectrometry by Johnson, Rudolph C., Zhou, Yingtao, Statler, Kristen, Thomas, Jerry, Cox, Frederick, Hall, Sherwood, Barr, John R.

“…Saxitoxin and neosaxitoxin are potent neurotoxins that can cause paralytic shellfish poisoning when consumed. A new assay is presented here to quantify…”
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Use of Diagnostic Ions for the Detection of Fentanyl Analogs in Human Matrices by LC–QTOF by Swanson, Kenneth D, Shaner, Rebecca L, Krajewski, Logan C, Bragg, William A, Johnson, Rudolph C, Hamelin, Elizabeth I

“…To combat the ongoing opioid epidemic, our laboratory has developed and evaluated an approach to detect fentanyl analogs in urine and plasma by screening…”
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High-Confidence Qualitative Identification of Organophosphorus Nerve Agent Adducts to Human Butyrylcholinesterase by Mathews, Thomas P, Carter, Melissa D, Johnson, Darryl, Isenberg, Samantha L, Graham, Leigh Ann, Thomas, Jerry D, Johnson, Rudolph C

“…In this study, a data-dependent, high-resolution tandem mass spectrometry (ddHRMS/MS) method capable of detecting all organophosphorus nerve agent (OPNA)…”
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Determination of Fentanyl Analog Exposure Using Dried Blood Spots with LC-MS-MS by Seymour, Craig, Shaner, Rebecca L, Feyereisen, Melanie C, Wharton, Rebekah E, Kaplan, Pearl, Hamelin, Elizabeth I, Johnson, Rudolph C

“…Fentanyl, and the numerous drugs derived from it, are contributing to the opioid overdose epidemic currently underway in the USA. To identify human exposure to…”
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Massive fatal overdose of abrin with progressive encephalopathy by Horowitz, B. Zane, Castelli, Rachel, Hughes, Adrienne, Hendrickson, Robert G., Johnson, Rudolph C., Thomas, Jerry D.

“…Introduction: The jequirity bean (Abrus precatorius) seed contains abrin, a toxalbumin, that irreversibly binds the 60-s ribosomal subunit inhibiting protein…”
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Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment by Onder, Seda, Schopfer, Lawrence M, Tacal, Ozden, Blake, Thomas A, Johnson, Rudolph C, Lockridge, Oksana

“…Chronic illness from exposure to organophosphorus toxicants is hypothesized to involve modification of unknown proteins. Tyrosine in proteins that have no…”
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Structural Characterization and Absolute Quantification of Microcystin Peptides Using Collision-Induced and Ultraviolet Photo-Dissociation Tandem Mass Spectrometry by Attard, Troy J., Carter, Melissa D., Fang, Mengxuan, Johnson, Rudolph C., Reid, Gavin E.

“…Microcystin (MC) peptides produced by cyanobacteria pose a hepatotoxic threat to human health upon ingestion from contaminated drinking water. While rapid MC…”
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Application of the fentanyl analog screening kit toward the identification of emerging synthetic opioids in human plasma and urine by LC-QTOF by Krajewski, Logan C., Swanson, Kenneth D., Bragg, William A., Shaner, Rebecca L., Seymour, Craig, Carter, Melissa D., Hamelin, Elizabeth I., Johnson, Rudolph C.

“…[Display omitted] •A LC-QTOF method for detection of fentanyl analogs was developed for human urine and plasma matrices.•A spectral library of 174 synthetic…”
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Detection of Brevetoxin in Human Plasma by ELISA by Cunningham, Brady R, Coleman, Rebecca M, Schaefer, Adam M, Hamelin, Elizabeth I, Johnson, Rudolph C

“…Abstract Florida red tides have become more common and persistent in and around the Gulf of Mexico. When in bloom, red tides can produce brevetoxins in high…”
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Development of a clinical assay to measure chlorinated tyrosine in hair and tissue samples using a mouse chlorine inhalation exposure model by Pantazides, Brooke G., Crow, Brian S., Quiñones-González, Jennifer, Perez, Jonas W., Harvilchuck, Jill A., Wallery, Jeffrey J., Hu, Tom C., Thomas, Jerry D., Johnson, Rudolph C., Blake, Thomas A.

“…Chlorine is a toxic industrial chemical with a history of use as a chemical weapon. Chlorine is also produced, stored, and transported in bulk making it a…”
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Investigation of dried blood sampling with liquid chromatography tandem mass spectrometry to confirm human exposure to nerve agents by Shaner, Rebecca L., Coleman, Rebecca M., Schulze, Nicholas, Platanitis, Kelsey, Brown, Ashli A., Seymour, Craig, Kaplan, Pearl, Perez, Jonas, Hamelin, Elizabeth I., Johnson, Rudolph C.

“…A method was developed to detect and quantify organophosphate nerve agent (OPNA) metabolites in dried blood samples. Dried blood spots (DBS) and microsampling…”
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