Search Results - "Johnson, Reid"

Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions by Jiang, Jiansen, Chan, Henry, Cash, Darian D., Miracco, Edward J., Loo, Rachel R. Ogorzalek, Upton, Heather E., Cascio, Duilio, Johnson, Reid O'Brien, Collins, Kathleen, Loo, Joseph A., Zhou, Z. Hong, Feigon, Juli

“…Telomerase helps maintain telomeres by processive synthesis of telomere repeat DNA at their 3'-ends, using an integral telomerase RNA (TER) and telomerase…”
Get full text

Simple and Sensitive Method for Deep Profiling of Host Cell Proteins in Therapeutic Antibodies by Combining Ultra-Low Trypsin Concentration Digestion, Long Chromatographic Gradients, and BoxCar Mass Spectrometry Acquisition by Nie, Song, Greer, Tyler, O’Brien Johnson, Reid, Zheng, Xiaojing, Torri, Albert, Li, Ning

“…Liquid chromatography coupled to mass spectrometry (LC-MS) is a powerful tool for the analysis of host cell proteins (HCP) during antibody drug process…”
Get full text

Field-Scale Transport and Transformation of Carboxymethylcellulose-Stabilized Nano Zero-Valent Iron by Johnson, Richard L, Nurmi, James T, O’Brien Johnson, Graham S, Fan, Dimin, O’Brien Johnson, Reid L, Shi, Zhenqing, Salter-Blanc, Alexandra J, Tratnyek, Paul G, Lowry, Gregory V

“…The fate of nano zerovalent iron (nZVI) during subsurface injection was examined using carboxymethylcellulose (CMC) stabilized nZVI in a very large…”
Get full text

Persulfate Persistence under Thermal Activation Conditions by Johnson, Richard L, Tratnyek, Paul G, Johnson, Reid O’Brien

“…Contaminant destruction with in situ chemical oxidation (ISCO) using persulfate (peroxydisulfate, S2O8 2−) can be enhanced by activation, which increases the…”
Get full text

Combination of FAIMS, Protein A Depletion, and Native Digest Conditions Enables Deep Proteomic Profiling of Host Cell Proteins in Monoclonal Antibodies by Johnson, Reid O’Brien, Greer, Tyler, Cejkov, Milos, Zheng, Xiaojing, Li, Ning

“…Host cell proteins (HCPs) are residual impurities generated by the expression cell line during the production of biopharmaceuticals. Although the majority of…”
Get full text

Control of the Serine Integrase Reaction: Roles of the Coiled-Coil and Helix E Regions in DNA Site Synapsis and Recombination by Mandali, Sridhar, Johnson, Reid C

“…Bacteriophage serine integrases catalyze highly specific recombination reactions between defined DNA segments called sites. These reactions are reversible…”
Get full text

Testing mechanisms of DNA sliding by architectural DNA-binding proteins: dynamics of single wild-type and mutant protein molecules in vitro and in vivo by Kamagata, Kiyoto, Itoh, Yuji, Tan, Cheng, Mano, Eriko, Wu, Yining, Mandali, Sridhar, Takada, Shoji, Johnson, Reid C

“…Abstract Architectural DNA-binding proteins (ADBPs) are abundant constituents of eukaryotic or bacterial chromosomes that bind DNA promiscuously and function…”
Get full text

DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis by Hancock, Stephen P, Stella, Stefano, Cascio, Duilio, Johnson, Reid C

“…The abundant Fis nucleoid protein selectively binds poorly related DNA sequences with high affinities to regulate diverse DNA reactions. Fis binds DNA…”
Get full text

High throughput and high confidence sequence variant analysis in therapeutic antibodies using Evosep One liquid chromatography tandem mass spectrometry with synthetic heavy peptides by Greer, Tyler, Johnson, Reid O’Brien, Nie, Song, Cejkov, Milos, Zheng, Xiaojing, Li, Ning

“…Sequence variants are anomalous misincorporations of amino acids into the primary structure of therapeutic antibodies during DNA replication and protein…”
Get full text

Maximizing hydrophobic peptide recovery in proteomics and antibody development using a mass spectrometry compatible surfactant by Nie, Song, O'Brien Johnson, Reid, Livson, Yuliya, Greer, Tyler, Zheng, Xiaojing, Li, Ning

“…Peptide loss due to surface absorption can happen at any step in a protein analysis workflow and is sometimes especially deleterious for hydrophobic peptides…”
Get full text

The shape of the DNA minor groove directs binding by the DNA-bending protein Fis by Stella, Stefano, Cascio, Duilio, Johnson, Reid C

“…The bacterial nucleoid-associated protein Fis regulates diverse reactions by bending DNA and through DNA-dependent interactions with other control proteins and…”
Get full text

Electron Transfer Dissociation Parameter Optimization Using Design of Experiments Increases Sequence Coverage of Monoclonal Antibodies by Cejkov, Milos, Greer, Tyler, Johnson, Reid O’Brien, Zheng, Xiaojing, Li, Ning

“…Middle-down analysis of monoclonal antibodies (mAbs) by tandem mass spectrometry (MS2) can provide detailed insight into their primary structure with minimal…”
Get full text

Integration of liquid chromatography mass spectrometry with a heavy peptide response curve accurately measures unprocessed C-terminal lysine during peptide mapping analysis of therapeutic antibodies in a single run by Greer, Tyler, O’Brien Johnson, Reid, Cejkov, Milos, Zheng, Xiaojing, Li, Ning

“…[Display omitted] •Novel, simple, accurate and cost-effective quantification of mAb unprocessed C-terminal K.•Incorporates heavy standards for both native and…”
Get full text

High Free-Energy Barrier of 1D Diffusion Along DNA by Architectural DNA-Binding Proteins by Kamagata, Kiyoto, Mano, Eriko, Ouchi, Kana, Kanbayashi, Saori, Johnson, Reid C.

“…Architectural DNA-binding proteins function to regulate diverse DNA reactions and have the defining property of significantly changing DNA conformation…”
Get full text

Cooperative DNA binding by proteins through DNA shape complementarity by Hancock, Stephen P, Cascio, Duilio, Johnson, Reid C

“…Localized arrays of proteins cooperatively assemble onto chromosomes to control DNA activity in many contexts. Binding cooperativity is often mediated by…”
Get full text

Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse by Smagris, Eriks, Shihanian, Lisa M, Mintah, Ivory J, Bigdelou, Parnian, Livson, Yuliya, Brown, Heather, Verweij, Niek, Hunt, Charleen, Johnson, Reid O'Brien, Greer, Tyler J, Hartford, Suzanne A, Hindy, George, Sun, Luanluan, Nielsen, Jonas B, Halasz, Gabor, Lotta, Luca A, Murphy, Andrew J, Sleeman, Mark W, Gusarova, Viktoria

“…Recent human genome-wide association studies have identified common missense variants in MARC1, p.Ala165Thr and p.Met187Lys, associated with lower hepatic fat,…”
Get full text

The HMGB chromatin protein Nhp6A can bypass obstacles when traveling on DNA by Kamagata, Kiyoto, Ouchi, Kana, Tan, Cheng, Mano, Eriko, Mandali, Sridhar, Wu, Yining, Takada, Shoji, Takahashi, Satoshi, Johnson, Reid C

“…Abstract DNA binding proteins rapidly locate their specific DNA targets through a combination of 3D and 1D diffusion mechanisms, with the 1D search involving…”
Get full text

Facilitated dissociation of transcription factors from single DNA binding sites by Kamar, Ramsey I., Banigan, Edward J., Erbas, Aykut, Giuntoli, Rebecca D., de la Cruz, Monica Olvera, Johnson, Reid C., Marko, John F.

“…The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative…”
Get full text

Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions by Hadizadeh Yazdi, Nastaran, Guet, Calin C., Johnson, Reid C., Marko, John F.

“…Summary We examine whether the Escherichia coli chromosome is folded into a self‐adherent nucleoprotein complex, or alternately is a confined but otherwise…”
Get full text

Rethinking Real Estate Pricing with Transformer Graph Neural Networks (T-GNN) by Moghimi, Faraz, Johnson, Reid A., Krause, Andy

“…Real Estate Pricing (Appraisal) seeks to estimate the "true" value of a house in the current marketplace. This task presents several distinct challenges that…”
Get full text