Search Results - "Johnson, Randall S."

HIF Transcription Factors, Inflammation, and Immunity by Palazon, Asis, Goldrath, Ananda W., Nizet, Victor, Johnson, Randall S.

“…The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF) transcription factors; these play an integral role in the…”
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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells by Takubo, Keiyo, Nagamatsu, Go, Kobayashi, Chiharu I., Nakamura-Ishizu, Ayako, Kobayashi, Hiroshi, Ikeda, Eiji, Goda, Nobuhito, Rahimi, Yasmeen, Johnson, Randall S., Soga, Tomoyoshi, Hirao, Atsushi, Suematsu, Makoto, Suda, Toshio

“…Defining the metabolic programs that underlie stem cell maintenance will be essential for developing strategies to manipulate stem cell capacity. Mammalian…”
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Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity by Lee, Yun Sok, Kim, Jung-Whan, Osborne, Olivia, Oh, Da Young, Sasik, Roman, Schenk, Simon, Chen, Ai, Chung, Heekyung, Murphy, Anne, Watkins, Steven M, Quehenberger, Oswald, Johnson, Randall S, Olefsky, Jerrold M

“…Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of…”
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Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection by Phan, Anthony T., Doedens, Andrew L., Palazon, Asis, Tyrakis, Petros A., Cheung, Kitty P., Johnson, Randall S., Goldrath, Ananda W.

“…Extensive metabolic changes accompany T cell activation, including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest…”
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Cytotoxic T-cells mediate exercise-induced reductions in tumor growth by Rundqvist, Helene, Veliça, Pedro, Barbieri, Laura, Gameiro, Paulo A, Bargiela, David, Gojkovic, Milos, Mijwel, Sara, Reitzner, Stefan Markus, Wulliman, David, Ahlstedt, Emil, Ule, Jernej, Östman, Arne, Johnson, Randall S

“…Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces malignant tumor progression, and clinically, exercise can improve…”
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HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity by Semba, Hiroaki, Takeda, Norihiko, Isagawa, Takayuki, Sugiura, Yuki, Honda, Kurara, Wake, Masaki, Miyazawa, Hidenobu, Yamaguchi, Yoshifumi, Miura, Masayuki, Jenkins, Dana M. R., Choi, Hyunsung, Kim, Jung-whan, Asagiri, Masataka, Cowburn, Andrew S., Abe, Hajime, Soma, Katsura, Koyama, Katsuhiro, Katoh, Manami, Sayama, Keimon, Goda, Nobuhito, Johnson, Randall S., Manabe, Ichiro, Nagai, Ryozo, Komuro, Issei

“…In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the…”
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Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success by Branco-Price, Cristina, Zhang, Na, Schnelle, Moritz, Evans, Colin, Katschinski, Dörthe M., Liao, Debbie, Ellies, Lesley, Johnson, Randall S.

“…The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as…”
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HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes by Guimarães-Camboa, Nuno, Stowe, Jennifer, Aneas, Ivy, Sakabe, Noboru, Cattaneo, Paola, Henderson, Lindsay, Kilberg, Michael S., Johnson, Randall S., Chen, Ju, McCulloch, Andrew D., Nobrega, Marcelo A., Evans, Sylvia M., Zambon, Alexander C.

“…Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including…”
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Hypoxia inducible factor (HIF) function in innate immunity and infection by Zinkernagel, Annelies S, Johnson, Randall S, Nizet, Victor

“…The hypoxia-inducible transcription factor (HIF-1alpha) is a major regulator of energy homeostasis and cellular adaptation to low oxygen stress. Recently,…”
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HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis by Miyauchi, Yoshiteru, Sato, Yuiko, Kobayashi, Tami, Yoshid, Shigeyuki, Mori, Tomoaki, Kanagawa, Hiroya, Katsuyama, Eri, Fujie, Atsuhiro, Wu Hao, Miyamoto, Kana, Tando, Toshimi, Morioka, Hideo, Matsumoto, Morio, Chambon, Pierre, Johnson, Randall S., Kato, Shigeaki, Toyama, Yoshiaki, Miyamoto, Takeshi

“…In women, estrogen deficiency after menopause frequently accelerates osteoclastic bone resorption, leading to osteoporosis, the most common skeletal disorder…”
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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo by Rankin, Erinn B, Biju, Mangatt P, Liu, Qingdu, Unger, Travis L, Rha, Jennifer, Johnson, Randall S, Simon, M Celeste, Keith, Brian, Haase, Volker H

“…Erythropoiesis is critically dependent on erythropoietin (EPO), a glycoprotein hormone that is regulated by hypoxia-inducible factor (HIF). Hepatocytes are the…”
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Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature by Scott, Andrew, Powner, Michael B, Gandhi, Pranita, Clarkin, Claire, Gutmann, David H, Johnson, Randall S, Ferrara, Napoleone, Fruttiger, Marcus

“…Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization,…”
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A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase by Luecke-Johansson, Sandra, Gralla, Michael, Rundqvist, Helene, Ho, Jolene Caifeng, Johnson, Randall S., Gradin, Katarina, Poellinger, Lorenz

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is known as a mediator of toxic responses. Recently, it was shown that the…”
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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs) by Peyssonnaux, Carole, Zinkernagel, Annelies S, Schuepbach, Reto A, Rankin, Erinn, Vaulont, Sophie, Haase, Volker H, Nizet, Victor, Johnson, Randall S

“…Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Hepcidin, a small peptide synthesized in the…”
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Acute Postnatal Ablation of Hif-2α Results in Anemia by Gruber, Michaela, Hu, Cheng-Jun, Johnson, Randall S., Brown, Eric J., Keith, Brian, Simon, M. Celeste

“…Adaptive transcriptional responses to oxygen deprivation (hypoxia) are mediated by the hypoxia-inducible factors (HIFs), heterodimeric transcription factors…”
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The role of Olfr78 in the breathing circuit of mice by Torres-Torrelo, Hortensia, Ortega-Sáenz, Patricia, Macías, David, Omura, Masayo, Zhou, Ting, Matsunami, Hiroaki, Johnson, Randall S., Mombaerts, Peter, López-Barneo, José

“…In response to hypoxia, neuron-like oxygen-sensitive glomus cells in the carotid body release neurotransmitters that rapidly activate afferent sensory fibres…”
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Acute and chronic hypoxia differentially predispose lungs for metastases by Reiterer, Moritz, Colaço, Renato, Emrouznejad, Pardis, Jensen, Anders, Rundqvist, Helene, Johnson, Randall S., Branco, Cristina

“…Oscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of…”
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Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia by Fang, Hsin-Yu, Hughes, Russell, Murdoch, Craig, Coffelt, Seth B., Biswas, Subhra K., Harris, Adrian L., Johnson, Randall S., Imityaz, Hongxia Z., Simon, M. Celeste, Fredlund, Erik, Greten, Florian R., Rius, Jordi, Lewis, Claire E.

“…Ischemia exists in many diseased tissues, including arthritic joints, atherosclerotic plaques, and malignant tumors. Macrophages accumulate in these sites and…”
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Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α–dependent function by Huang, Yan, Lei, Li, Liu, DingGang, Jovin, Ion, Russell, Raymond, Johnson, Randall S, Di Lorenzo, Annarita, Giordano, Frank J

“…Although intimately positioned between metabolic substrates in the bloodstream and the tissue parenchymal cells that require these substrates, a major role of…”
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microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation by Peng, Han, Kaplan, Nihal, Hamanaka, Robert B, Katsnelson, Julia, Blatt, Hanz, Yang, Wending, Hao, Liangliang, Bryar, Paul J, Johnson, Randall S, Getsios, Spiro, Chandel, Navdeep S, Lavker, Robert M

“…Notch plays a critical role in the transition from proliferation to differentiation in the epidermis and corneal epithelium. Furthermore, aberrant Notch…”
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