Search Results - "Johnson, Philip M"
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Enhancement and maximum in the isobaric specific-heat capacity measurements of deeply supercooled water using ultrafast calorimetry
Published in Proceedings of the National Academy of Sciences - PNAS (09-02-2021)“…Knowledge of the temperature dependence of the isobaric specific heat (Cp) upon deep supercooling can give insights regarding the anomalous properties of…”
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Local vibrational coherences drive the primary photochemistry of vision
Published in Nature chemistry (01-12-2015)“…The role of vibrational coherence—concerted vibrational motion on the excited-state potential energy surface—in the isomerization of retinal in the protein…”
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Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Published in Nature communications (17-02-2023)“…The binding and release of ligands from their protein targets is central to fundamental biological processes as well as to drug discovery. Photopharmacology…”
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Excited-State Vibronic Dynamics of Bacteriorhodopsin from Two-Dimensional Electronic Photon Echo Spectroscopy and Multiconfigurational Quantum Chemistry
Published in The journal of physical chemistry letters (21-05-2020)“…Owing to the ultrafast time scale of the photoinduced reaction and high degree of spectral overlap among the reactant, product, and excited electronic states…”
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Azidohomoalanine: A Minimally Invasive, Versatile, and Sensitive Infrared Label in Proteins To Study Ligand Binding
Published in The journal of physical chemistry. B (08-11-2018)“…The noncanonical amino acid azidohomoalanine (Aha) is known to be an environment-sensitive infrared probe for the site-specific investigation of protein…”
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A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
Published in Nature communications (02-12-2023)“…Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein…”
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Design, Implementation, and Evaluation of Open Power Quality
Published in Energies (Basel) (01-08-2020)“…Modern electrical grids are transitioning from a centralized generation architecture to an architecture with significant distributed, intermittent generation…”
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Spin cascade and doming in ferric hemes: Femtosecond X-ray absorption and X-ray emission studies
Published in Proceedings of the National Academy of Sciences - PNAS (08-09-2020)“…The structure–function relationship is at the heart of biology, and major protein deformations are correlated to specific functions. For ferrous heme proteins,…”
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The photocycle and ultrafast vibrational dynamics of bacteriorhodopsin in lipid nanodiscs
Published in Physical chemistry chemical physics : PCCP (21-10-2014)“…The photocycle and vibrational dynamics of bacteriorhodopsin in a lipid nanodisc microenvironment have been studied by steady-state and time-resolved…”
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Fast infrared spectroscopy of protein dynamics: advancing sensitivity and selectivity
Published in Current opinion in structural biology (01-10-2015)“…•The untapped potential of 2D-IR spectroscopy lies in its high direct time resolution.•The major limitation of 2D-IR spectroscopy for larger proteins is…”
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Femtosecond-to-millisecond structural changes in a light-driven sodium pump
Published in Nature (London) (09-07-2020)“…Light-driven sodium pumps actively transport small cations across cellular membranes 1 . These pumps are used by microorganisms to convert light into membrane…”
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Two-dimensional spectroscopy of a molecular dimer unveils the effects of vibronic coupling on exciton coherences
Published in Nature chemistry (01-03-2014)“…The observation of persistent oscillatory signals in multidimensional spectra of protein–pigment complexes has spurred a debate on the role of…”
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13
Accessing metal-specific orbital interactions in C-H activation with resonant inelastic X-ray scattering
Published in Chemical science (Cambridge) (2024)“…Photochemically prepared transition-metal complexes are known to be effective at cleaving the strong C-H bonds of organic molecules in room temperature…”
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The Speed of Allosteric Signaling Within a Single-Domain Protein
Published in The journal of physical chemistry letters (06-05-2021)“…While much is known about different allosteric regulation mechanisms, the nature of the allosteric signal and the time scale on which it propagates remains…”
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Dynamics and mechanism of a light-driven chloride pump
Published in Science (American Association for the Advancement of Science) (25-02-2022)“…Chloride transport by microbial rhodopsins is an essential process for which molecular details such as the mechanisms that convert light energy to drive ion…”
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The Primary Photochemistry of Vision Occurs at the Molecular Speed Limit
Published in The journal of physical chemistry. B (27-04-2017)“…Ultrafast photochemical reactions are initiated by vibronic transitions from the reactant ground state to the excited potential energy surface, directly…”
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Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Published in Nature chemistry (01-04-2024)“…Charge-transfer reactions in proteins are important for life, such as in photolyases which repair DNA, but the role of structural dynamics remains unclear…”
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Quantifying Biomolecular Recognition with Site-Specific 2D Infrared Probes
Published in The journal of physical chemistry letters (18-05-2017)“…Azidohomoalanine (Aha) is an unnatural amino acid containing an infrared active azido side chain group that can, through frequency shifts of the azido stretch…”
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Correlation of refractive index based and THz streaking arrival time tools for a hard X‐ray free‐electron laser
Published in Journal of synchrotron radiation (01-03-2024)“…To fully exploit ultra‐short X‐ray pulse durations routinely available at X‐ray free‐electron lasers to follow out‐of‐equilibrium dynamics, inherent arrival…”
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2D-IR Spectroscopy of an AHA Labeled Photoswitchable PDZ2 Domain
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (14-12-2017)“…We explore the capability of the non-natural amino acid azidohomoalanine (AHA) as an IR label to sense relatively small structural changes in proteins with the…”
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