Search Results - "Johnson, Peter R. A"

Connective Tissue Growth Factor Induces Extracellular Matrix in Asthmatic Airway Smooth Muscle by Johnson, Peter R. A, Burgess, Janette K, Ge, Qi, Poniris, Maree, Boustany, Sarah, Twigg, Stephen M, Black, Judith L

“…Transforming growth factor (TGF)-beta and connective tissue growth factor may be implicated in extracellular matrix protein deposition in asthma. We have…”
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A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro by Burgess, Janette K., Oliver, Brian G.G., Poniris, Maree H., Ge, Qi, Boustany, Sarah, Cox, Natalie, Moir, Lyn M., Johnson, Peter R.A., Black, Judith L.

“…Airway smooth muscle (ASM) cells may contribute to airway remodeling through the release of growth factors, cytokines, and extracellular matrix (ECM) proteins…”
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Expression of Connective Tissue Growth Factor in Asthmatic Airway Smooth Muscle Cells by Burgess, Janette K, Johnson, Peter R. A, Ge, Qi, Au, Wendy W, Poniris, Maree H, McParland, Brent E, King, Greg, Roth, Michael, Black, Judith L

“…There is strong evidence to implicate transforming growth factor-beta in the remodeling that occurs in asthma, as levels are increased in bronchial lavage…”
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Airway Smooth Muscle Cell Proliferation Is Increased in Asthma by JOHNSON, PETER R. A, ROTH, MICHAEL, TAMM, MICHAEL, HUGHES, MARGARET, GE, QI, KING, GREG, BURGESS, JANETTE K, BLACK, JUDITH L

“…Increased airway smooth muscle (ASM) within the bronchial wall of asthmatic patients has been well documented and is likely to be the result of increased…”
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Airway smooth muscle and fibroblasts in the pathogenesis of asthma by Johnson, Peter R A, Burgess, Janette K

“…Asthma is a disease characterized by marked structural changes within the airway wall. These changes include deposition of extracellular matrix proteins and an…”
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Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism by Johnson, Peter R.A., Burgess, Janette K., Underwood, P.Anne, Au, Wendy, Poniris, Maree H., Tamm, Michael, Ge, Qi, Roth, Michael, Black, Judith L.

“…Airway remodeling is a key feature of persistent asthma and includes alterations in the extracellular matrix protein profile around the airway smooth muscle…”
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Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix by Burgess, Janette K, Ge, Qi, Poniris, Maree H, Boustany, Sarah, Twigg, Stephen M, Black, Judith L, Johnson, Peter R A

“…Airway remodeling describes the structural changes that occur in the asthmatic airway that include airway smooth muscle hyperplasia, increases in vascularity…”
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Increased sensitivity of asthmatic airway smooth muscle cells to prostaglandin E2 might be mediated by increased numbers of E-prostanoid receptors by Burgess, Janette K., Ge, Qi, Boustany, Sarah, Black, Judith L., Johnson, Peter R.A.

“…An increase in airway smooth muscle (ASM) cell proliferation leads to an increase in the bulk of the ASM, one of the characteristic features of asthma. We have…”
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ERK activation and mitogenesis in human airway smooth muscle cells by Lee, J H, Johnson, P R, Roth, M, Hunt, N H, Black, J L

“…Asthmatic airways are characterized by an increase in smooth muscle mass, due mainly to hyperplasia. Many studies suggest that extracellular signal-regulated…”
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Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle by Chambers, L S, Black, J L, Poronnik, P, Johnson, P R

“…The protease-activated receptor (PAR)-2 is present on the smooth muscle and epithelium of human airways and can be activated by mast cell tryptase, trypsin, or…”
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Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: A possible role in asthma? by Burgess, Janette K., Carlin, Stephen, Pack, Robert A., Arndt, Greg M., Au, Wendy W., Johnson, Peter R.A., Black, Judith L., Hunt, Nicholas H.

“…The airway smooth muscle (ASM) cell, originally thought of as a passive structural cell, is now well recognized as an active participant in the pathologic…”
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Airway basement membrane perimeter in human airways is not a constant; potential implications for airway remodeling in asthma by McParland, Brent E, Pare, Peter D, Johnson, Peter R. A, Armour, Carol L, Black, Judith L

“…Departments of 1 Pharmacology and 3 Pharmacy, University of Sydney, New South Wales 2006, Australia; and 2 University of British Columbia, James Hogg iCAPTURE…”
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Cyclosporine a mediates fibroproliferation through epithelial cells by HOSTETTLER, Katrin E, ROTH, Michael, BURGESS, Janette K, JOHNSON, Peter R. A, GLANVILLE, Allan R, TAMM, Michael, BLACK, Judith L, BORGER, Peter

“…Obliterative bronchiolitis (OB) is the major cause of morbidity and mortality after lung transplantation. The potential role of immunosuppressive drugs in the…”
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Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma by Burgess, Janette K., Lee, Jin Hee, Ge, Qi, Ramsay, Emma E., Poniris, Maree H., Parmentier, Johannes, Roth, Michael, Johnson, Peter R.A., Hunt, Nicholas H., Black, Judith L., Ammit, Alaina J.

“…Hyperplasia of airway smooth muscle (ASM) within the bronchial wall of asthmatic patients has been well documented and is likely due to increased muscle…”
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A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion by Ko, Fanny W S, Diba, Chantale, Roth, Michael, McKay, Karen, Johnson, Peter R A, Salome, Cheryl, King, Gregory G

“…The rate of decline in lung function is increased in asthmatic patients, particularly in those with coexisting asthmatic mucus hypersecretion (AMH), in whom…”
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The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture : The effect of beclomethasone by JOHNSON, Peter R. A, BLACK, Judith L, CARLIN, Stephen, QI GE, UNDERWOOD, P. Anne

“…Airway remodeling is a key feature of persistent asthma. Part of the remodeling process involves the laying down of extracellular matrix (ECM) proteins within…”
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CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle by Burgess, Janette K., Blake, Anita E., Boustany, Sarah, Johnson, Peter R.A., Armour, Carol L., Black, Judith L., Hunt, Nicholas H., Hughes, J. Margaret

“…Severe, persistent asthma is characterized by airway smooth muscle hyperplasia, inflammatory cell infiltration into the smooth muscle, and increased expression…”
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Mechanisms of airway remodeling: Airway smooth muscle by BLACK, Judith L, ROTH, Michael, LEE, Jinhee, CARLIN, Stephen, JOHNSON, Peter R. A

“…The airway smooth muscle cell can contract; relax; participate in allergic and inflammatory responses by expressing adhesion molecules, releasing cytokines,…”
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Factors controlling smooth muscle proliferation and airway remodelling by Black, Judith L, Johnson, Peter R.A

“…It is clear that airway smooth muscle plays an important role in the hyperresponsiveness and remodelling that occur in the asthmatic airway. This is by virtue…”
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Interleukin-4 inhibits mitogen-induced proliferation of human airway smooth muscle cells in culture by Hawker, K M, Johnson, P R, Hughes, J M, Black, J L

“…The increase in the amount of airway smooth muscle in the bronchial wall associated with asthma is partly due to hyperplasia. It is therefore important to…”
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